Results 21 to 30 of about 28,885 (301)

Incidence and clinical importance of perioperative histamine release: randomised study of volume loading and antihistamines after induction of anaesthesia [PDF]

, 1994
Although histamine release is recognised as a common event during anaesthesia and surgery, few clinicians judge the resultant cardiorespiratory disturbances serious enough to warrant prophylaxis with antihistamines.
Lorenz, Wilfried, Doenicke, A., Weber, Doris, Junginger, T., Stinner, B., Duda, D., Black, A., Menke, H., Trial Group, Mainz/Marburg, Sitter, H., Dick, W.   +10 more
core   +1 more source

Intact Cell Binding for In Vitro Prediction of Sedative and Non-sedative Histamine H1–Receptor Antagonists Based on Receptor Internalization

Journal of Pharmacological Sciences, 2008
We evaluated changes in the binding properties of sedative and non-sedative histamine H1–receptor antagonists induced by internalization of H1 receptors in intact human U373 MG astrocytoma cells.
Shigeru Hishinuma, Yuko Sato, Yusuke Kobayashi, Hiroshi Komazaki, Masaki Saito   +4 more
doaj   +1 more source

ANTISECRETORY TREATMENT FOR PEDIATRIC GASTROESOPHAGEAL REFLUX DISEASE - A SYSTEMATIC REVIEW

Arquivos de Gastroenterologia, 2017
BACKGROUND: Proton pump inhibitors and histamine H2 receptor antagonists are two of the most commonly prescribed drug classes for pediatric gastroesophageal reflux disease, but their efficacy is controversial.
Ângelo Zambam de MATTOS, Gabriela Meirelles MARCHESE, Bárbara Brum FONSECA, Carlos KUPSKI, Marta Brenner MACHADO   +4 more
doaj   +1 more source

Votucalis, a Novel Centrally Sparing Histamine-Binding Protein, Attenuates Histaminergic Itch and Neuropathic Pain in Mice

Frontiers in Pharmacology, 2022
Votucalis is a biologically active protein in tick (R. appendiculatus) saliva, which specifically binds histamine with high affinity and, therefore, has the potential to inhibit the host’s immunological responses at the feeding site. We hypothesized that
Ibrahim Alrashdi, Ibrahim Alrashdi, Amal Alsubaiyel, Amal Alsubaiyel, Michele Chan, Michele Chan, Emma E. Battell, Abdel Ennaceur, Miles A. Nunn, Wayne Weston-Davies, Paul L. Chazot, Ilona Obara, Ilona Obara   +12 more
doaj   +1 more source

Novel chalcone-based fluorescent human histamine H 3 receptor ligands as pharmacological tools [PDF]

, 2012
Novel fluorescent chalcone-based ligands at human histamine H(3) receptors (hH(3)R) have been designed, synthesized, and characterized. Compounds described are non-imidazole analogs of ciproxifan with a tetralone motif.
Miriam Tomasch, Lilia Weizel, Weizel, Lilia, Stark, Holger, Tomasch, Miriam, Holger Stark, Schwed, J. Stephan, J. Stephan Schwed   +7 more
core   +1 more source

Effects of First- and Second-Generation Histamine-H1-Receptor Antagonists on the Pentobarbital-Induced Loss of the Righting Reflex in Streptozotocin-Induced Diabetic Mice

Journal of Pharmacological Sciences, 2005
The second-generation histamine-H1-receptor antagonists, such as epinastine and cetirizine, are used as non-sedating antihistamines for treating allergic symptoms due to their poor ability to penetrate blood-brain barrier.
Junzo Kamei, Shoko Hirano, Shigeo Miyata, Akiyoshi Saitoh, Kenji Onodera   +4 more
doaj   +1 more source

Determination of histamine in human plasma: the European external quality control study 1988 [PDF]

, 1990
There is an increasing interest in measuring human plasma histamine levels in various clinical conditions. A variety of 'old' and newly developed techniques are applied to meet this demand.
Lorenz, Wilfried, Neugebauer, E., W. LORENZ, Keyzer, J. J., E. COSTING, Oosting, E., E. NEUGEBAUER, J. J. KEYZER   +7 more
core   +1 more source

Pitolisant and Other Histamine-3 Receptor Antagonists—An Update on Therapeutic Potentials and Clinical Prospects

Medicines, 2020
Background: Besides its well-known role as a peripheral chemical mediator of immune, vascular, and cellular responses, histamine plays major roles in the central nervous system, particularly in the mediation of arousal and cognition-enhancement.
Victoria Harwell, Pius S. Fasinu
doaj   +1 more source

Histamine and Delirium: Current Opinion

Frontiers in Pharmacology, 2019
Delirium is a very common, but refractory clinical state, notably present in intensive care and in the growing aging community. It is characterized by fluctuating disturbances in a number of key behavioral features, namely cognition, mood, attention ...
Paul L. Chazot, Laura Johnston, Edel Mcauley, Stephen Bonner   +3 more
doaj   +1 more source

Plasticity of histamine H3 receptor expression and binding in the vestibular nuclei after labyrinthectomy in rat [PDF]

, 2004
Background: In rat, deafferentation of one labyrinth (unilateral labyrinthectomy) results in a characteristic syndrome of ocular and motor postural disorders (e.g., barrel rotation, circling behavior, and spontaneous nystagmus). Behavioral recovery (e.g.,
Panula, Pertti, Lozada, Adrian F., Kaj Karlstedt, Karlstedt, Kaj, Aarnisalo, Antti A., Stark, Holger, Adrian F Lozada, Pertti Panula, Antti A Aarnisalo, Holger Stark   +9 more
core   +1 more source