Results 91 to 100 of about 8,121 (227)

Comparative Sleep Architecture Profiles of Antidepressants in Mice: Pharmacological Characterization of Paroxetine, Sertraline, Duloxetine, Mirtazapine and Vortioxetine

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
This study compared five antidepressants (paroxetine, sertraline, duloxetine, mirtazapine, and vortioxetine) in mice using EEG/EMG, revealing distinct effects on REM and NREM sleep. The figure illustrates changes in sleep architecture during the light phase (ZT0–12).
Junya Maruoka, Ryo Egami, Yuto Akita, Kohei Kozuka, Yusuke Kakumoto, Tetsuro Kikuchi, Kazuhiko Kume   +6 more
wiley   +1 more source

Dualistic H1-mediated effect of histamine on the isolated human intestine

, 2005
Histamine (HA) contracts gastrointestinal smooth muscle cells from both animals and humans through the activation of H1 receptors. The recent discovery of the H4 receptor subtype, causing a rise in the intracellular Ca2+ levels and then representing a ...
POZZOLI, Cristina, REGINA C., MENOZZI, Alessandro, POLI, Enzo, RONCORONI, Luigi, REGINA G., CORUZZI G.   +6 more
core   +1 more source

Histamine receptors in GtoPdb v.2023.1

, 2023
Histamine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Histamine Receptors [80, 174]) are activated by the endogenous ligand histamine. Marked species differences exist between histamine receptor orthologues [80]. The human and rat
Hill, Stephen J., Young, J. Michael, Steve Liu, Jean-Charles Schwartz, Shankley, Nigel P., Haas, Helmut L., Holger Stark, Nigel P. Shankley, Robin Thurmond, Paul Chazot, Stephen J. Hill, Fukui, Hiroyuki, Hills, Rebecca, J. Michael Young, Levi, Roberto, Leurs, Rob, Marlon Cowart, Rebecca Hills, Cowart, Marlon, Gutzmer, Ralf, C. Robin Ganellin, Seifert, Roland, Ganellin, C. Robin, Rob Leurs, Roberto Levi, Timmerman, Henk, Stark, Holger, Panula, Pertti, Hiroyuki Fukui, Schunack, Walter, Chazot, Paul, Roland Seifert, Liu, Steve, Schwartz, Jean-Charles, Walter Schunack, Henk Timmerman, Pertti Panula, Helmut L. Haas, Thurmond, Robin, Ralf Gutzmer   +39 more
core   +1 more source

Molecular Determinants Responsible for Sedative and Non-sedative Properties of Histamine H1–Receptor Antagonists

Journal of Pharmacological Sciences, 2014
There is argument whether non-sedative properties of histamine H1–receptor antagonists (antihistamines) are determined by their active extrusions from the brain via P-glycoprotein or their restricted penetration through the blood-brain barrier.
Yoshihiro Uesawa, Shigeru Hishinuma, Masaru Shoji   +2 more
doaj   +1 more source

Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley   +1 more source

Histamine H1 and H2 Receptor Antagonists Accelerate Skin Barrier Repair and Prevent Epidermal Hyperplasia Induced by Barrier Disruption in a Dry Environment

, 2001
Keratinocytes have histamine H1 and H2 receptors, but their functions are poorly understood. To clarify the role of histamine receptors in the epidermis, we examined the effects of histamine receptor antagonists and agonists applied epicutaneously on the
Denda, Mitsuhiro, Hirao, Tetsuji, Ashida, Yutaka   +2 more
core   +1 more source

Histamine H4 receptor regulates IL-6 and INF-γ secretion in native monocytes from healthy subjects and patients with allergic rhinitis

Clinical and Translational Allergy, 2019
Histamine H1 receptor (H1R) and histamine H4 receptor (H4R) are essential in allergic inflammation. The roles of H4R have been characterized in T cell subsets, whereas the functional properties of H4R in monocytes remain unclear.
Hua Peng, Jian Wang, Xiao Yan Ye, Jie Cheng, Cheng Zhi Huang, Li Yue Li, Tian Ying Li, Chun Wei Li   +7 more
doaj   +1 more source

Inhibition of bone resorption in tissue culture by H1-receptor antagonists

, 1983
Mouse bone culture studies show that several representative H1-receptor antagonists, promethazine hydrochloride, pyrilamine maleate, tripelennamine hydrochloride, and diphenhydramine hydrochloride, inhibit parathyroid extract-stimulated bone resorption.
L. Rabadjija, P. Goldhaber
core   +1 more source

Histamine receptors in GtoPdb v.2021.3

, 2021
Histamine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Histamine Receptors [80, 173]) are activated by the endogenous ligand histamine. Marked species differences exist between histamine receptor orthologues [80]. The human and rat
Levi, Roberto, Leurs, Rob, Cowart, Marlon, Hill, Stephen J., Young, J. Michael, Gutzmer, Ralf, Seifert, Roland, Ganellin, C. Robin, Shankley, Nigel P., Timmerman, Henk, Haas, Helmut L., Stark, Holger, Panula, Pertti, Schunack, Walter, Chazot, Paul, Fukui, Hiroyuki, Liu, Steve, Schwartz, Jean-Charles, Hills, Rebecca, Thurmond, Robin   +19 more
core   +1 more source

Development of novel ligands influencing neurotransmission in the central nervous system

, 2007
The development of novel drugs targeting GPCRs is of particular interest since modulation of subfamilies of this receptor class highly influences neurotransmission in the central nervous system.
Sasse, Britta Caroline
core