Results 91 to 100 of about 251,504 (224)

Effects of administration of histamine and its H1, H2, and H3 receptor antagonists into the primary somatosensory cortex on inflammatory pain in rats [PDF]

Iranian Journal of Basic Medical Sciences, 2014
Objective(s): The present study investigated the effects of microinjection of histamine and histamine H1, H2, and H3 receptor antagonists, chlorpheniramine, ranitidine and thioperamide, respectively into the primary somatosensory cortex (PSC) on ...
Esmaeal Tamaddonfard, Nasrin Hamzeh Gooshchi   +1 more
doaj  

Histamine H1 receptor antagonists enhance the efficacy of antibacterials against Escherichia coli

BMC Veterinary Research, 2019
Background H1 receptor antagonists are commonly used for the treatment of allergic diseases. The aim of this study was to find out, if antihistaminic compounds like mepyramine have the ability to influence the activity of antibacterials.
G. G. Bruer, P. Hagedorn, M. Kietzmann, A. F. Tohamy, V. Filor, E. Schultz, S. Mielke-Kuschow, J. Meissner   +7 more
doaj   +1 more source

West Syndrome Associated with Administration of a Histamine H1 Antagonist, Oxatomide

The Kurume Medical Journal, 2004
We report a 4-month-old female infant who developed West syndrome eleven days after administration of a histamine H1 antagonist, oxatomide, for atopic dermatitis. It has been reported that some histamine H1 antagonists induce seizures in epileptic patients.
YAMASHITA, YUSHIRO, ISAGAI, TAKEO, SEKI, YOSHITAKA, OHYA, TAKASHI, NAGAMITSU, SHINICHIRO, MATSUISHI, TOYOJIRO   +5 more
openaire   +3 more sources

Mouse P19 embryonal carcinoma cells express functional histamine H1-receptors

, 1993
In the present study, we have investigated the response in P19 embryonal carcinoma (EC) cells to histamine. We show that these cells, that resemble the pluripotent cells of an early mouse embryo, respond to histamine addition by a transient increase in ...
Leurs, R, Tertoolen, L G, Smit, M J; id_orcid, Bloemers, S M, de Laat, S W, Timmerman, H, Verheule, S   +6 more
core   +1 more source

Histamine H4 receptor regulates IL-6 and INF-γ secretion in native monocytes from healthy subjects and patients with allergic rhinitis

Clinical and Translational Allergy, 2019
Histamine H1 receptor (H1R) and histamine H4 receptor (H4R) are essential in allergic inflammation. The roles of H4R have been characterized in T cell subsets, whereas the functional properties of H4R in monocytes remain unclear.
Hua Peng, Jian Wang, Xiao Yan Ye, Jie Cheng, Cheng Zhi Huang, Li Yue Li, Tian Ying Li, Chun Wei Li   +7 more
doaj   +1 more source

Molecular Determinants Responsible for Sedative and Non-sedative Properties of Histamine H1–Receptor Antagonists

Journal of Pharmacological Sciences, 2014
There is argument whether non-sedative properties of histamine H1–receptor antagonists (antihistamines) are determined by their active extrusions from the brain via P-glycoprotein or their restricted penetration through the blood-brain barrier.
Yoshihiro Uesawa, Shigeru Hishinuma, Masaru Shoji   +2 more
doaj   +1 more source

Papel do receptor ativado por proteinases-2 (par-2) no comportamento de coçar em camundongos [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pos-Graduação em Farmacologia, Florianópolis, 2009.O objetivo do presente estudo foi investigar os possíveis mecanismos e mediadores envolvidos no
Costa, Robson da
core  

Synthesis and pharmacological identification of neutral histamine H1-receptor antagonists

, 2003
In the present study we searched for neutral antagonists for the human histamine
Smit, Martine J., Smit, M.J.; id_orcid, Leurs, Rob, van de Wetering, I., van de Wetering, Ineke, Timmerman, H., Elz, S., Govoni, Marinella, Timmerman, Henk, Menge, Wiro M. B. P., Menge, W.M.P.B., Schunack, W., Elz, Sigurd, Bakker, Remko A., Schunack, Walter, Bakker, R.A., Govoni, M, Leurs, R.   +17 more
core   +1 more source

Screening and identification of the H1R antagonists from natural products by BODIPY FL histamine recognition and DPHD-anchored bombardment coupled with target cell extraction

Frontiers in Pharmacology
IntroductionHistamine is an important mediator of allergy, and inhibiting its binding to H1 receptors (H1R) is a key method to alleviate allergic diseases.
Xinqi Li, Guizhou Hu, Guizhou Hu, Xu Chen, Can Di, Jin Qi   +5 more
doaj   +1 more source

Crystallographic and conformational studies on histamine H1-receptor antagonists. IV. On the stereochemical vector of antihistaminic activity

, 1986
The geometries of 14 histamine H1-receptor antagonists have been compared with the aim of finding out a common stereochemical vector of antihistaminic activity.
BERTOLASI, Valerio, BOREA, Pier Andrea, GILLI, Gastone   +2 more
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