Results 101 to 110 of about 267,254 (237)

Effects of Trazodone on Testicular Morphology, Sperm Parameters and Contractility of the Distal Cauda Epididymal Duct in Rats

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
ABSTRACT Trazodone is an antidepressant approved for the treatment of major depressive disorder and is associated with a low incidence of sexual dysfunction. However, its effects on male reproductive health are not yet fully understood. Therefore, this study aimed to evaluate the effects of repeated trazodone administration on reproductive parameters ...
Maria Santana da Silva, Vitória Barros Marques, Fernanda Karoline Oliveira da Silva, Maele Oliveira de Sena, Yanka do Vale Carvalho, Bruna da Silva Figueiredo, Luana Talinne da Costa Gomes, Samia Ellen Alves Fernandes, Edherlayne Bezerra dos Santos Silva, Jackson Nazareno Gomes de Lima, Anna Karynna Alves de Alencar Rocha, Expedito Silva do Nascimento Junior, Elaine Cristina Gavioli, Edilson Dantas da Silva Junior   +13 more
wiley   +1 more source

Dualistic H1-mediated effect of histamine on the isolated human intestine

, 2005
Histamine (HA) contracts gastrointestinal smooth muscle cells from both animals and humans through the activation of H1 receptors. The recent discovery of the H4 receptor subtype, causing a rise in the intracellular Ca2+ levels and then representing a ...
POZZOLI, Cristina, REGINA C., MENOZZI, Alessandro, POLI, Enzo, RONCORONI, Luigi, REGINA G., CORUZZI G.   +6 more
core   +1 more source

Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm

British Journal of Pharmacology, Volume 183, Issue 19, Page 5701-5731, October 2026.
Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley   +1 more source

Synthesis and pharmacological identification of neutral histamine H1-receptor antagonists

, 2003
In the present study we searched for neutral antagonists for the human histamine
Smit, Martine J., Smit, M.J.; id_orcid, Leurs, Rob, Smit, M.J., van de Wetering, I., van de Wetering, Ineke, Wetering, I. van de, Timmerman, H., Elz, S., Govoni, Marinella, Timmerman, Henk, Menge, Wiro M. B. P., Menge, W.M.P.B., Schunack, W., Elz, Sigurd, Bakker, Remko A., Schunack, Walter, Bakker, R.A., Govoni, M, Leurs, R.   +19 more
core   +1 more source

Screening and identification of the H1R antagonists from natural products by BODIPY FL histamine recognition and DPHD-anchored bombardment coupled with target cell extraction

Frontiers in Pharmacology
IntroductionHistamine is an important mediator of allergy, and inhibiting its binding to H1 receptors (H1R) is a key method to alleviate allergic diseases.
Xinqi Li, Guizhou Hu, Guizhou Hu, Xu Chen, Can Di, Jin Qi   +5 more
doaj   +1 more source

GWAS of Second‐Generation Antihistamine Use: Locus Specificity and Highlighted Signalling Pathways

Clinical &Experimental Allergy, EarlyView.
M. Niemi, S. Ruotsalainen, E. Saarentaus, I. Vähätalo, F. FinnGen, I. Starskaia, T. Harju, M. Pelkonen, T. Feuth, P. Kauppi, J. Partanen, R. Lahesmaa, V. Hytönen, A. Palotie, H. Kankaanranta, T. Laitinen   +15 more
wiley   +1 more source

Versatile Detection of Cellular Protein via Fluorescence Anisotropy

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Cell Lysate Fluorescence Anisotropy (CFAST) utilizes long lifetime dye‐labeled nanobodies for rapid protein quantification in minimally purified, complex cell lysate. When coupled with cellular thermal shift, CFAST allows high‐throughput detection of endogenous protein‐small molecule engagement, facilitating the discovery of novel binders for ...
Qing Tang, Yuan‐Ping Wei, Ricky Ruiqi Ma, Na Wei, Tammy Zihan Zhou, Hilary Kung‐Yu Ho, Zafar Iqbal Bhat, Iqra Ishrat, Xiaoyu Li, Judy Wai Ping Yam, Yung Hou Wong, Qiankun Wang, Justin L. Tan   +12 more
wiley   +1 more source

Role and immunomodulatory profile of histamine receptors by H1 and H2 antagonists [PDF]

, 2008
The present study was designed to delineate the immunomodulatory role of histamine receptors (H1- and H2-) on induction of antibody response to sheep red blood cells (SRBC), as well as the antibody generation profile, in rabbit system, systemically.
Mohd. Shahid, Trivendra Tripathi, Rahat Khan, Mashiatullah Siddiqui   +3 more
core  

Activation of Microglia by Histamine and Substance P

Cellular Physiology and Biochemistry, 2014
Background: Activated microglia perform many of the immune effector functions typically associated with macrophages. However, the regulators involved in microglial activation are not well defined.
Jin Zhu, Chen Qu, Xiang Lu, Shu Zhang
doaj   +1 more source

Anti‐Allergic Potentials of Actinodaphne angustifolia: Integrated In Vivo Evaluation and In Silico Analysis of Bioactive Compounds

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Actinodaphne angustifolia leaf extract exhibited significant anti‐allergic activity in a TDI‐induced mouse model, reducing sneezing, nasal scratching, nasal scores, WBC counts, and serum IgE levels. The extract was non‐toxic and rich in bioactive polyphenols, particularly (−) epicatechin and rutin hydrate.
Rabindra Nath Acharyya, Md. Abid Muktadir Risha, Novi Dwi Widya Rini, Sarita Manandhar, Sabina Shahi, Biswa Nath Bhadra, Asish Kumar Das, Katsuhiko Ariga, Shrabanti Dev, Lok Kumar Shrestha   +9 more
wiley   +1 more source