Results 21 to 30 of about 267,254 (237)

Histamine H1 receptor antagonist attenuates catecholamine surge and organ injury after severe burns

Frontiers in Endocrinology, 2023
Severe burns induce a catecholamine surge, causing severe damage to the organism and raising the possibility of multisystem organ failure. Few strategies are generally acceptable to reduce catecholamine surge and organ injury post-burn.
Jizhuang Wang, Chenghao Lu, Xinying Liu, Gai Zhang, Jie Zhang, Min Gao, Dan Liu, Xiong Zhang, Yan Liu   +8 more
doaj   +1 more source

Novel chalcone-based fluorescent human histamine H 3 receptor ligands as pharmacological tools [PDF]

, 2012
Novel fluorescent chalcone-based ligands at human histamine H(3) receptors (hH(3)R) have been designed, synthesized, and characterized. Compounds described are non-imidazole analogs of ciproxifan with a tetralone motif.
Miriam Tomasch, Lilia Weizel, Weizel, Lilia, Stark, Holger, Tomasch, Miriam, Holger Stark, Schwed, J. Stephan, J. Stephan Schwed   +7 more
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Perioperative nonspecific histamine release: a new classification by aetiological mechanisms and evaluation of their clinical relevance [PDF]

, 1993
As a consequence of the performance of a randomized controlled clinical trial on perioperative histamine release and cardiovascular and respiratory disturbances, several types of increases in plasma histamine had to be distinguished instead of only two ...
Lorenz, Wilfried, Schäfer, U., Junginger, T., Stinner, B., Nies, C., Duda, D., Hasse, C., Menke, H., Rothmund, M., Sitter, H.   +9 more
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Blocking Histamine H1 Improves Learning and Mnemonic Dysfunction in Mice With Social Isolation Plus Repeated Methamphetamine Injection

Journal of Pharmacological Sciences, 2008
The aim of this study was to investigate the effects of histamine H1 and H3 antagonists on learning and mnemonic dysfunction in mice. Two H1 antagonists, pyrilamine and clozapine, and the prototypic H3 antagonist thioperamide were used to study the role ...
Feiyong Jia, Jalal Izadi Mobarakeh, Hongmei Dai, Motohisa Kato, Ajing Xu, Tomohiro Okuda, Eiko Sakurai, Nobuyuki Okamura, Kazuhiro Takahashi, Kazuhiko Yanai   +9 more
doaj   +1 more source

Investigations on neuropeptide Y and histamine receptors by fluorescence-based and radiochemical methods [PDF]

, 2011
In the last three decades, a large amount of experimental data (for example Förster resonance energy transfer (FRET) at fluorescently labelled receptors) supported the hypothesis of the dimerization of G-protein-coupled receptors (GPCR), including ...
Lopuch, Miroslaw
core   +1 more source

Histamine and Delirium: Current Opinion

Frontiers in Pharmacology, 2019
Delirium is a very common, but refractory clinical state, notably present in intensive care and in the growing aging community. It is characterized by fluctuating disturbances in a number of key behavioral features, namely cognition, mood, attention ...
Paul L. Chazot, Laura Johnston, Edel Mcauley, Stephen Bonner   +3 more
doaj   +1 more source

Plasticity of histamine H3 receptor expression and binding in the vestibular nuclei after labyrinthectomy in rat [PDF]

, 2004
Background: In rat, deafferentation of one labyrinth (unilateral labyrinthectomy) results in a characteristic syndrome of ocular and motor postural disorders (e.g., barrel rotation, circling behavior, and spontaneous nystagmus). Behavioral recovery (e.g.,
Panula, Pertti, Lozada, Adrian F., Kaj Karlstedt, Karlstedt, Kaj, Aarnisalo, Antti A., Stark, Holger, Adrian F Lozada, Pertti Panula, Antti A Aarnisalo, Holger Stark   +9 more
core   +1 more source

Histamine H1 Receptors in Neural Stem Cells Are Required for the Promotion of Neurogenesis Conferred by H3 Receptor Antagonism following Traumatic Brain Injury

Stem Cell Reports, 2019
Summary: The neurological recovery following traumatic brain injury (TBI) is limited, largely due to a deficiency in neurogenesis. The present study explores the effects of histamine H3 receptor (H3R) antagonism on TBI and mechanisms related to ...
Rujia Liao, Youchao Chen, Li Cheng, Lishi Fan, Han Chen, Yushan Wan, Yi You, Yanrong Zheng, Lei Jiang, Zhong Chen, Xiangnan Zhang, Weiwei Hu   +11 more
doaj   +1 more source

Histamine induced high mobility group box-1 release from vascular endothelial cells through H1 receptor

Frontiers in Immunology, 2022
BackgroundSystemic allergic reaction is characterized by vasodilation and vascular leakage, which causes a rapid, precipitous and sustained decrease in arterial blood pressure with a concomitant decrease of cardiac output.
Shangze Gao, Shangze Gao, Shangze Gao, Keyue Liu, Wenhan Ku, Dengli Wang, Hidenori Wake, Handong Qiao, Kiyoshi Teshigawara, Masahiro Nishibori   +9 more
doaj   +1 more source

The Histamine H4 Receptor: From Orphan to the Clinic

Frontiers in Pharmacology, 2015
The histamine H4 receptor (H4R) was first noted as a sequence in genomic databases that had features of a G-protein coupled receptor. This putative receptor was found to bind histamine consistent with its homology to other histamine receptors and thus ...
Robin L. Thurmond
doaj   +1 more source