Results 41 to 50 of about 251,504 (224)

Performance studies with the H1‐histamine receptor antagonists, astemizole and terfenadine. [PDF]

British Journal of Clinical Pharmacology, 1982
1 Effects of the antihistamines, terfenadine (60 mg) and astemizole (10 and 20 mg), on performance (visuo‐motor coordination, arithmetical ability and digit symbol substitution) and on mood were studied in six healthy adult females. The study was double‐blind, placebo controlled and included an antihistamine with known central effects (triprolidine 10 ...
A N, Nicholson, B M, Stone
openaire   +2 more sources

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Pharmacological study of ebastine, a novel histamine H1-receptor antagonist.

Folia Pharmacologica Japonica, 1994
The anti-allergic activity of ebastine, a novel antihistamine, was assessed in comparison with several antihistamines. 1) Orally administered ebastine dose-dependently inhibited 7-day homologous passive cutaneous anaphylaxis (PCA), experimental allergic rhinitis and experimental asthma in guinea pigs or rats (ED50-values were 2.17, 0.29 and 0.35 mg/kg,
YAKUO, Ikuhisa, ISHII, Katsumi, SETO, Yasuhiro, IMANO, Kiyomi, TAKEYAMA, Kunihiko, NAKAMURA, Hideo, KARASAWA, Tadahiko   +6 more
openaire   +3 more sources

Cetirizine a histamine H1 receptor antagonist improves viral myocarditis [PDF]

Journal of Inflammation, 2010
We showed that mast cells played a critical role in the progression of heart failure induced by pressure overload and viral myocarditis in mice. In this study, we investigated the effect of cetirizine, a selective H1 receptor antagonist, on experimental viral myocarditis induced by encephalomyocarditis (EMC) virus.Four-week-old inbred male DBA/2 mice ...
Yamamoto Kanjo, Matsumori Akira, Shimada Miho   +2 more
openaire   +3 more sources

Biosensors for Food Safety and Adulteration Monitoring: Applications, Smart Packaging Integration, and Pathways to Intelligent, Field‐Deployable Detection Systems

Food Safety and Health, EarlyView.
Biosensors enable rapid, sensitive, and portable detection of pathogens, contaminants, allergens, and food adulteration. Integration with smart packaging, smartphones, IoT, and machine learning supports real‐time monitoring and intelligent decision‐making, whereas microfluidics, biodegradable materials, explainable AI, and blockchain offer pathways ...
Mohima Akther Any, Abid Hassan Arnab, Liza Akter, Yusuf Chowdhury, Md. Hassan Bin Nabi, Md Abu Rayhan, Nazmul Islam, Wahidu Zzaman   +7 more
wiley   +1 more source

Histamine H1- and H2-receptors in pulmonary and systemic vasculature of the dog

, 1975
This study was conducted to identify and clarify the actions of pulmonary and systemic H1- and H2-receptors by utilizing specific histamine receptor antagonists.
RF Grover, EK Weir, JT Reeves, A Tucker
core   +1 more source

Histamine release in anaesthesia and surgery. premedication with H1- and H2-receptor antagonists: indications, benefits and possible problems [PDF]

, 1982
Our clinical and experimental studies have so far demonstrated, that the drugs used in anaesthesia; such as hypnotics, sedatives, narcotics or muscle relaxants, release histamine. The intravenous short acting anaesthetic etomidate has not shown either in
Doenicke, A., Lorenz, Wilfried
core   +1 more source

The Efficacy of Bepotastine Besilate Compared With Hydroxyzine Pamoate for Preventing Infusion Reactions to the First Dose of Rituximab in Patients With Non-Hodgkin Lymphoma: Protocol for a Phase II, Double-Blind, Multicenter Randomized Trial

JMIR Research Protocols
BackgroundRituximab, an anti-CD20 monoclonal antibody, can cause infusion reactions (IRs), especially during the initial rituximab infusion therapy.
Yumi Kitahiro, Kazuhiro Yamamoto, Kimikazu Yakushijin, Takeshi Ioroi, Masaaki Tanda, Kotaro Itohara, Tomohiro Omura, Hironobu Minami, Ikuko Yano   +8 more
doaj   +1 more source

On the Mechanisms Underlying Histamine Induction of Gastric Mucosal Lesions in Rats With Partial Gastric Vascular Occlusion

Journal of Pharmacological Sciences, 2003
Although it is well known that histamine induces gastric mucosal lesions in laboratory animals, the fundamental mechanisms remain unclear. In order to further analyze the vascular mechanisms underlying histamine-induced lesions, a new model was developed
Kikuko Amagase, Susumu Okabe
doaj   +1 more source

Evaluation of the Histamine H1-Antagonist-Induced Place Preference in Rats

Japanese Journal of Pharmacology, 1999
The place preferences by some histamine H1 antagonists, such as tripelennamine, optical isomers of chlorpheniramine (dl-, d- and l-forms) and pyrilamine, in rats were evaluated with the conditioned place preference paradigm. In the present study, tripelennamine and all of the optical isomers of chlorpheniramine, but not pyrilamine, produced a ...
Suzuki, Tsutomu, Mori, Tomohisa, Tsuji, Minoru, Nomura, Mutsuko, Misawa, Miwa, Onodera, Kenji   +5 more
openaire   +2 more sources