Results 61 to 70 of about 251,504 (224)

Pharmacology of Antihistamines

World Allergy Organization Journal, 2011
This article reviews the molecular biology of the interaction of histamine with its H1-receptor and describes the concept that H1-antihistamines are not receptor antagonists but are inverse agonists i.e.
Diana S Church, MD, Martin K Church, PhD
doaj   +1 more source

Votucalis, a Novel Centrally Sparing Histamine-Binding Protein, Attenuates Histaminergic Itch and Neuropathic Pain in Mice

Frontiers in Pharmacology, 2022
Votucalis is a biologically active protein in tick (R. appendiculatus) saliva, which specifically binds histamine with high affinity and, therefore, has the potential to inhibit the host’s immunological responses at the feeding site. We hypothesized that
Ibrahim Alrashdi, Ibrahim Alrashdi, Amal Alsubaiyel, Amal Alsubaiyel, Michele Chan, Michele Chan, Emma E. Battell, Abdel Ennaceur, Miles A. Nunn, Wayne Weston-Davies, Paul L. Chazot, Ilona Obara, Ilona Obara   +12 more
doaj   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

The Effects of Histaminergic Agents in the Nucleus ccumbens of Rats in the Elevated Plus-Maze Test of Anxiety [PDF]

Iranian Journal of Psychiatry, 2010
"n Objective: "n The nucleus accumbens (NAc) receive histaminergic neurons from tuberomammillary nuclei. There are reports indicating that central histamine systems are involved in many physiological behavioral processes, including anxiety.
Ameneh Rezayof, Saba Taheri, Mohammad-Reza Zarrindast   +2 more
doaj  

Swiss Practice Recommendations for Chronic Prurigo Including Prurigo Nodularis

International Journal of Dermatology, EarlyView.
Chronic prurigo, including prurigo nodularis, is a chronic, often treatment‐refractory condition characterized by persistent pruritus and chronic scratch lesions. Advances in the understanding of its underlying pathophysiology have enabled the development of novel targeted therapies; however, management remains challenging due to the expanding range of
Simon M. Mueller, Helmut Beltraminelli, Wolf‐Henning Boehncke, Maximilian Böhm, Antonio Cozzio, Peter Häusermann, Ahmad Jalili, Antonios G. A. Kolios, Claudia Lang, Eva Loos, Christoph Schlapbach, Curdin Conrad   +11 more
wiley   +1 more source

Scratching behavior in mice associated with IgE-mediated allergic cutaneous reaction and its pharmacological characterization

Allergology International, 1997
Scratching behavior observed after epicutaneous challenge with the antigen 2,4-dinitrofluorobenzene (DNFB) in the ear of BALB/c mice passively sensitized with anti-dinitrophenol (DNP).
Keiichi Musoh, Nobuaki Nakamura, Toshimi Sakurai, Naoki Inagaki, Hiroichi Nagai   +4 more
doaj   +1 more source

Pathophysiology and emerging treatments for dermographic, cholinergic and cold urticaria

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This review illustrates key proposed mast cell‐mediated activation pathways in dermographic, cholinergic and cold urticaria, highlighting IgE‐dependent and ‐independent mechanisms. These pathways are increasingly targeted by emerging drugs, aiming to interrupt mast cell activation and mediator release, offering more precise, mechanism‐based treatment ...
Mojca Bizjak‐Suran, Matjaž Fležar, Manuel Pedro Pereira   +2 more
wiley   +1 more source

Active analog approach to Histamine HI receptor antagonists

, 1992
Molecular modeling studies have been carried out to compare static, electronic and electrostatic properties of some Histamine H1 receptor antagonists using SYBYL package.
Christine M. Genua, Arthur Ritter, Ritter, Arthur, David Kristol, Yadav, Janardan, Janardan Yadav, Laxminarayan, Swamy, Kristol, David, Gerula, Christine M., Swamy Laxminarayan   +9 more
core   +1 more source

Bronchial biopsy and sequential bronchoalveolar lavage in atopic cough: In view of the effect of histamine H1-receptor antagonists

Allergology International, 2000
We have shown that some patients presenting with chronic bronchodilator-resistant non-productive cough have global atopic tendency, airway cough hyper-sensitivity without non-specific bronchial hyperresponsiveness and eosinophilic inflammation of the ...
Masaki Fujimura, Kouichi Nishi, Takio Ohka, Masahide Yasui, Kazuo Kasahara   +4 more
doaj   +1 more source

Management of chronic urticaria: Current status and future prospect

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Chronic urticaria is driven by mast cell activation through autoimmune, inflammatory, and neuroimmune pathways. A structured approach combining diagnosis, patient‐reported outcomes, stepwise therapy, treatment optimization, monitoring and emerging targeted agents may improve disease control and enable more personalized management.
Andaç Salman, Mona Al‐Ahmad, Maryam Al‐Nesf, Chia‐Yu Chu, Luis Felipe Ensina, Ana M. Gimenez‐Arnau, Margarida Gonçalo, Clive Grattan, Michihiro Hide, Pavel Kolkhir, Martin Metz, Iman Nasr, Romi Saini, Simon Francis Thomsen, Torsten Zuberbier, Emek Kocaturk   +15 more
wiley   +1 more source