Results 91 to 100 of about 39,913 (287)

The effect of common medications on the efficacy of immune checkpoint inhibitors

Cancer, Volume 131, Issue 24, 15 December 2025.
Abstract Background Medications such as proton pump inhibitors (PPIs), antihistamines, and nonsteroidal anti‐inflammatory drugs have been linked to immune checkpoint inhibitor (ICI) efficacy in patients with non–small cell lung cancer (NSCLC), but these associations may reflect unmeasured confounding rather than true pharmacologic effects.
Daria Brinzevich, Virginia Falvello, Sadiq S. Rehmani, Garth W. Strohbehn, Nithya Ramnath, Michael P. Dykstra, Luke M. Higgins, David Elliott, Matthew J. Schipper, Michael D. Green, Alex K. Bryant   +10 more
wiley   +1 more source

Histamine H1 Receptors in Neural Stem Cells Are Required for the Promotion of Neurogenesis Conferred by H3 Receptor Antagonism following Traumatic Brain Injury

Stem Cell Reports, 2019
Summary: The neurological recovery following traumatic brain injury (TBI) is limited, largely due to a deficiency in neurogenesis. The present study explores the effects of histamine H3 receptor (H3R) antagonism on TBI and mechanisms related to ...
Rujia Liao, Youchao Chen, Li Cheng, Lishi Fan, Han Chen, Yushan Wan, Yi You, Yanrong Zheng, Lei Jiang, Zhong Chen, Xiangnan Zhang, Weiwei Hu   +11 more
doaj   +1 more source

Targeting Histamine H4 Receptor in the Rostral Ventromedial Medulla to Relieve Hypertension

Advanced Science, Volume 12, Issue 45, December 4, 2025.
H4R and its downstream TRPV1 channel mediate the excitatory effect of TMN histaminergic afferent inputs on GABAergic sympathoinhibitory neurons in RVMM. Intranasal delivery of selective H4R agonist VUF 8430 suppresses renal sympathetic outflow and elicits sustained depressor and bradycardia responses in SHRs and CUMS‐induced hypertensive rats ...
Ying Shi, Yang‐Xun Zhang, Jun‐Yi Chen, Sai Ma, Wei‐Xuan Xue, Wei Li, Qian‐Xiao Li, Bo Song, Ya‐Ting Li, Hong‐Yu Ma, Shu‐Tao Xie, Hong‐Zhao Li, Di‐Jun Chen, Qi‐Peng Zhang, Hui‐Jie Ma, Jian‐Jun Wang, Lei Yu, Xiao‐Yang Zhang, Jing‐Ning Zhu   +18 more
wiley   +1 more source

Gastric ulceration in dog: A review

Veterinary World, 2013
The common acid related diseases of the upper gastrointestinal tract could be considered as primarily due to the defect in barrier function either of the gastric mucosal or duodenal epithelium leading to the formation of gastric or duodenal ulcers.
J. D. Parrah, B. A. Moulvi, Mohsin Ali Gazi, D. M. Makhdoomi, H. Athar, Shahid Dar, A. Q. Mir   +6 more
doaj   +1 more source

Relevance of Hydrogen Bonds for the Histamine H2 Receptor-Ligand Interactions: A Lesson from Deuteration

Biomolecules, 2020
We used a combination of density functional theory (DFT) calculations and the implicit quantization of the acidic N−H and O−H bonds to assess the effect of deuteration on the binding of agonists (2-methylhistamine and 4-methylhistamine) and ...
Mojca Kržan, Jan Keuschler, Janez Mavri, Robert Vianello   +3 more
doaj   +1 more source

Six Cases of Antihistamine-Resistant Dermographic Urticaria Treated with Oral Ciclosporin

Allergology International, 2011
Background: Dermographic urticaria (DU) is characterized by strong itch and wheals induced by mechanical scratching. H1-receptor antagonists may reduce symptoms of DU to some extent, but other treatments being used for chronic spontaneous urticaria, such
Sayuri Toda, Shunsuke Takahagi, Shoji Mihara, Michihiro Hide   +3 more
doaj   +1 more source

Medicamente și tratamente alternative pentru ulcerul peptic [PDF]

Medicamentul Veterinar, 2021
Peptic ulcer is a chronic disease that affects up to 10% of the world's population. The appearance of peptic ulcer is dependent on the presence of gastric juice and its pH and the decrease of the mucosal defense.
Sergiu Aurel Orasan - Alic, Razvan Florin Moruzi, Eugenia Dumitrescu, Florin Muselin, Alexandru Octavian Doma, Corina Marina Kracunovic, Erieg Abdulawab Mohamed, Romeo Teodor Cristina   +7 more
doaj  

Efficacy of cimetidin in the prevention of ulcer formation in the stomach during immobilization stress [PDF]

The effect of stress on the formation of ulcers in the mucous membrane of the stomach, the increase in cyclic adenosine monophosphate level in the gastric tissues, and parietal cell structure alteration.
Dorofeyev, G. I., Gavrovskaya, L. K., Ivashkin, V. T., Litovskiy, I. A.   +3 more
core   +1 more source

Effect of an antiandrogenic H2 receptor antagonist on hepatic regeneration in rats [PDF]

, 1988
Because biochemical 'feminization' of the liver in males is observed with hepatic regeneration and because the hepatic regenerative response in females is greater than that in males, the posibility that antiandrogens might potentiate liver regeneration ...
Chapchap, P, Eagon, PK, Kahn, D, Makowka, L, Podesta, L, Starzl, TE, Svanas, GW, Van Thiel, DH   +7 more
core  

Pharmacogenomic and structural analysis of constitutive G-protein coupled receptor activity [PDF]

, 2007
Premi a l'excel·lència investigadora. Àmbit de les Ciències de la Salut. 2008G-protein coupled receptors (GPCRs) respond to a chemically diverse plethora of signal transduction molecules.
Aldo Jongejan, Alewijnse AE, Ariens EJ, Brown EM, Cesarman E, Chen F, Clark AJ, Clark AJ, Cobbs CS, Furchgott RF, Furchgott RF, Garcia-Borron JC, Henk Timmerman, Henry F. Vischer, Leonardo Pardo, Mannstadt M, Martine J. Smit, Murphy PM, Nauta WT, Rauser L, Reiter EO, Remko A. Bakker, Rob Leurs, Rossier O, Samama P, Scheer A, Stephenson RP, Tabs S, Weiner DM, Wieland K   +29 more
core   +3 more sources