Results 91 to 100 of about 19,031 (233)
Background: Proton-pump inhibitors (PPI) and histamine-2 receptor antagonists (H2RA) are common acid suppressants used in gastrointestinal disorders. The trend of usage in Malaysia has changed from predominantly H2RA to PPI from 2007 to 2008, 3.46 versus
Oh AL+8 more
doaj +1 more source
Inferring Synergistic and Antagonistic Interactions in Mixtures of Exposures [PDF]
There is abundant interest in assessing the joint effects of multiple exposures on human health. This is often referred to as the mixtures problem in environmental epidemiology and toxicology. Classically, studies have examined the adverse health effects of different chemicals one at a time, but there is concern that certain chemicals may act together ...
arxiv
Delayed phase of Hematoporphyrin-Induced Phototoxicity: Modulation by Complement, Leukocytes, and Antihistamines [PDF]
We have investigated the role of complement, leukocytes, and histamine in the delayed phase of hematoporphyrin-induced phototoxicity in guinea pigs. The phototoxic response was quantified by the accumulation of intravenously injected [125I]bovine serum ...
Gigli, Irma+3 more
core +1 more source
Abstract Vonoprazan is a novel acid blocker with greater potency than proton pump inhibitors. A Japanese study reported no significant safety concerns over 5 years of Vonoprazan use; however, elevated serum gastrin and increased parietal cell and foveolar hyperplasia were observed, and long‐term safety data beyond 5 years are limited.
Hiroko Suda, Sachi Eto, Koichi Sakurai
wiley +1 more source
Allergic Rhinoconjunctivitis: the Role of Histamine
Allergic rhinoconjunctivitis is the most common atopic condition encountered in clinical practice. Analysis of the pathogenesis of this condition permits identification of optimal therapeutic targets.
M. Andersson, L. Greiff, C. Svensson
doaj +1 more source
Altruism and Antagonistic Pleiotropy in Penna Ageing Model [PDF]
The Penna ageing model is based on mutation accumulation theory. We show that it also allows for self-organization of antagonistic pleiotropy which helps at young age at the expense of old age. This can be interpreted as emergence of altruism.
arxiv
Monoaminergic Neuropathology in Alzheimer's disease [PDF]
Acknowledgments This work was supported by The Croatian Science Foundation grant. no. IP-2014-09-9730 (“Tau protein hyperphosphorylation, aggregation, and trans-synaptic transfer in Alzheimer’s disease: cerebrospinal fluid analysis and assessment of ...
Bažadona, Danira+11 more
core +1 more source
Our study looks at the association between microRNA expression and disease resistance in Caribbean staghorn corals infected with White Band Disease. We find three microRNAs differentially expressed due to disease resistance with putative targets involved in innate immunity.
Brecia A. Despard+3 more
wiley +1 more source
Although it is well known that histamine induces gastric mucosal lesions in laboratory animals, the fundamental mechanisms remain unclear. In order to further analyze the vascular mechanisms underlying histamine-induced lesions, a new model was developed
Kikuko Amagase, Susumu Okabe
doaj
Characterization and development of cimetidine as a histamine H2-receptor antagonist
The concept of two classes of histamine receptor, H1 and H2, is introduced and the chemical derivation of histamine H2-receptor antagonists is outlined briefly. Starting from the structure of histamine, chemical modification led eventually to burimamide, the first described histamine H2-receptor antagonist.
W. A. M. Duncan+6 more
openaire +3 more sources