Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale. [PDF]
Geriatr Gerontol IntABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Mogi M +4 more
europepmc +2 more sources
Histamine‐2 (H2) antagonists can be safely removed from standard paclitaxel premedication regimens
British Journal of Clinical Pharmacology, 2022 The aim of this study is to investigate the rates of hypersensitivity reactions (HSRs) in patients receiving paclitaxel chemotherapy, with and without a histamine‐2 (H2) antagonists.
E. Foreman +3 more
semanticscholar +1 more source
Suppression of wheal and flare in histamine test by the main H1 antihistamines commercialized in Brazil [PDF]
Anais Brasileiros de Dermatologia, 2018 : Background: Several dermatoses are mediated by histamine, such as urticaria, angioedema, and papular urticaria. There are no Brazilian studies comparing the potency of antihistamines.
Helena Maciel-Guerra +6 more
doaj +2 more sources
Prediction of Ventilator-Associated Pneumonia in Patients Undergoing Stress Ulcer Prophylaxis: A Longitudinal Descriptive Study in Iran [PDF]
Journal of Kerman University of Medical Sciences, 2020 Background: The purpose of this study was to investigate and predict ventilator-associated pneumonia (VAP) in the two groups of patients who received either proton pump inhibitors (Pantoprazole) or histamine H2 antagonist (Ranitidine).
Shahriar Nikpour +7 more
doaj +1 more source
Effectiveness and Safety of Histamine H2 Receptor Antagonists: An Umbrella Review of Meta‐Analyses
Journal of clinical pharmacology, 2022 Histamine H2 receptor antagonists (H2RAs) were widely used to inhibit gastric acid secretion, but its association with adverse events remains controversial and unclear. We conducted an umbrella review of meta‐analyses to systematically assess the quality
Rui Meng +8 more
semanticscholar +1 more source
Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells
Scientific Reports, 2021 Cancer therapy is often hampered by the disease’s development of resistance to anticancer drugs. We previously showed that the autonomously upregulated product of fibroblast growth factor 13 gene (FGF13; also known as FGF homologous factor 2 (FHF2)) is ...
Nobuki Matsumoto +5 more
doaj +1 more source
Pitolisant Inhibits Alcohol Drinking and Improves Withdrawal Negative Affect Through Lateral Habenula Histaminergic Signaling in Mice. [PDF]
CNS Neurosci TherPitolisant, an FDA‐approved H3R antagonist, counteracts the rewarding and sedative effects of ethanol, reduces alcohol intake, and alleviates the negative affect during withdrawal. This might occur via the antagonism of presynaptic autoreceptors and heteroreceptors H3Rs in the lateral habenula, thereby activating the H2R/p‐CREB/BDNF signaling and ...
Zhao Y +13 more
europepmc +2 more sources
Famotidine-induced reversal of meperidine-related serotonin syndrome: a case report [PDF]
Korean Journal of Anesthesiology, 2017 Serotonin syndrome is an unexpected fatal adverse event related to serotonergic medication. This case report is the first report describing the possible treatment effect of famotidine on serotonin syndrome.
Soohyun Joe +5 more
doaj +1 more source
RELEASE OF HISTAMINE BY H2-RECEPTOR ANTAGONISTS [PDF]
The Lancet, 1982 letter
Parkin, J. V. +4 more
openaire +3 more sources
Antihistaminergics and inverse agonism. Potential therapeutic applications [PDF]
, 2013 The accurate characterization of the molecular mechanisms involved in the action of receptor ligands is important for their appropriate therapeutic use and safety.
Davio, Carlos Alberto +4 more
core +9 more sources