DEN OpenGastric hyperplastic polyps can cause gastrointestinal bleeding, and their enlargement has been associated with long‐term acid‐suppressive therapy. Vonoprazan (VPZ), a potassium‐competitive acid blocker, provides potent acid suppression and may induce ...
Kengo Kasuga +9 more
doaj +2 more sources
Wake-promoting neuromodulators in Alzheimer's disease: Implications for sleep and brain clearance. [PDF]
Alzheimers DementAbstract Neuromodulatory subcortical systems (NSS) regulate arousal, cognition, and sleep–wake transitions through widespread influence on cortical and subcortical networks. Increasing evidence links dysfunction of these systems to the pathogenesis of Alzheimer's disease (AD). Degeneration and dysregulation of NSS occurs during the preclinical phase of
Pedersen TJ +7 more
europepmc +2 more sources
Alterations in histamine responses between juvenile and adult urinary bladder urothelium, lamina propria and detrusor tissues [PDF]
, 2020 Inflammatory mediators may have a role in various lower urinary tract disorders. Histamine is known to induce significant increases in both the tension and frequency of spontaneous phasic contractions in both urothelium with lamina propria (U&LP) and
Chess-Williams, Russ +2 more
core +1 more source
Effectiveness and Safety of Histamine H2 Receptor Antagonists: An Umbrella Review of Meta‐Analyses
Journal of clinical pharmacology, 2022 Histamine H2 receptor antagonists (H2RAs) were widely used to inhibit gastric acid secretion, but its association with adverse events remains controversial and unclear. We conducted an umbrella review of meta‐analyses to systematically assess the quality
Rui Meng +8 more
semanticscholar +1 more source
Antihistaminergics and inverse agonism. Potential therapeutic applications [PDF]
, 2013 The accurate characterization of the molecular mechanisms involved in the action of receptor ligands is important for their appropriate therapeutic use and safety.
Davio, Carlos Alberto +4 more
core +12 more sources
Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells
Scientific Reports, 2021 Cancer therapy is often hampered by the disease’s development of resistance to anticancer drugs. We previously showed that the autonomously upregulated product of fibroblast growth factor 13 gene (FGF13; also known as FGF homologous factor 2 (FHF2)) is ...
Nobuki Matsumoto +5 more
doaj +1 more source
Famotidine-induced reversal of meperidine-related serotonin syndrome: a case report [PDF]
Korean Journal of Anesthesiology, 2017 Serotonin syndrome is an unexpected fatal adverse event related to serotonergic medication. This case report is the first report describing the possible treatment effect of famotidine on serotonin syndrome.
Soohyun Joe +5 more
doaj +1 more source
ANTISECRETORY TREATMENT FOR PEDIATRIC GASTROESOPHAGEAL REFLUX DISEASE - A SYSTEMATIC REVIEW
Arquivos de Gastroenterologia, 2017 BACKGROUND: Proton pump inhibitors and histamine H2 receptor antagonists are two of the most commonly prescribed drug classes for pediatric gastroesophageal reflux disease, but their efficacy is controversial.
Ângelo Zambam de MATTOS +4 more
doaj +1 more source
The Quantum Nature of Drug-Receptor Interactions: Deuteration Changes Binding Affinities for Histamine Receptor Ligands. [PDF]
PLoS ONE, 2016 In this article we report a combined experimental and computational study concerning the effects of deuteration on the binding of histamine and two other histaminergic agonists to 3H-tiotidine-labeled histamine H2 receptor in neonatal rat astrocytes ...
Mojca Kržan +7 more
doaj +1 more source
Neuropharmacological targets for drug action in vestibular sensory pathways [PDF]
, 2017 The use of pharmacological agents is often the preferred approach to the management of vestibular dysfunction. In the vestibular sensory pathways, the sensory neuroepithelia are thought to be influenced by a diverse number of neuroactive substances that ...
Jones, Timothy A, Lee, Choongheon
core +3 more sources