Results 11 to 20 of about 8,363 (180)

Votucalis, a Novel Centrally Sparing Histamine-Binding Protein, Attenuates Histaminergic Itch and Neuropathic Pain in Mice

Frontiers in Pharmacology, 2022
Votucalis is a biologically active protein in tick (R. appendiculatus) saliva, which specifically binds histamine with high affinity and, therefore, has the potential to inhibit the host’s immunological responses at the feeding site. We hypothesized that
Ibrahim Alrashdi, Ibrahim Alrashdi, Amal Alsubaiyel, Amal Alsubaiyel, Michele Chan, Michele Chan, Emma E. Battell, Abdel Ennaceur, Miles A. Nunn, Wayne Weston-Davies, Paul L. Chazot, Ilona Obara, Ilona Obara   +12 more
doaj   +1 more source

Predictors of Response to Oral Medications and Low-Histamine Diet in Patients with Chronic Urticaria

Journal of Immunology Research, 2022
Background. Chronic urticaria (CU) is comprised of diverse phenotypes, and thus, a shift towards a precision medical approach is warranted in its management. Methods. This study enrolled 78 patients with CU.
Hui-Ling Chiang, Chen-Hung Chen, Malcolm Koo, Tzung-Yi Tsai, Cheng-Han Wu   +4 more
doaj   +1 more source

Histamine and Delirium: Current Opinion

Frontiers in Pharmacology, 2019
Delirium is a very common, but refractory clinical state, notably present in intensive care and in the growing aging community. It is characterized by fluctuating disturbances in a number of key behavioral features, namely cognition, mood, attention ...
Paul L. Chazot, Laura Johnston, Edel Mcauley, Stephen Bonner   +3 more
doaj   +1 more source

Histamine H2-receptor antagonists for urticaria

Cochrane Database of Systematic Reviews, 2012
Urticaria is a common skin disease characterised by itching weals or hives, which can occur almost anywhere on the body. There are a number of different subtypes and a range of available treatment options. There is lack of agreement on the efficacy of H2-receptor antagonists used in the treatment of urticaria.To assess the safety and effectiveness of ...
Fedorowicz, Z., Zuuren, E.J. van, Hu, N.F.   +2 more
openaire   +4 more sources

On the Mechanisms Underlying Histamine Induction of Gastric Mucosal Lesions in Rats With Partial Gastric Vascular Occlusion

Journal of Pharmacological Sciences, 2003
Although it is well known that histamine induces gastric mucosal lesions in laboratory animals, the fundamental mechanisms remain unclear. In order to further analyze the vascular mechanisms underlying histamine-induced lesions, a new model was developed
Kikuko Amagase, Susumu Okabe
doaj   +1 more source

The Histamine H4 Receptor: From Orphan to the Clinic

Frontiers in Pharmacology, 2015
The histamine H4 receptor (H4R) was first noted as a sequence in genomic databases that had features of a G-protein coupled receptor. This putative receptor was found to bind histamine consistent with its homology to other histamine receptors and thus ...
Robin L. Thurmond
doaj   +1 more source

Histamine induced high mobility group box-1 release from vascular endothelial cells through H1 receptor

Frontiers in Immunology, 2022
BackgroundSystemic allergic reaction is characterized by vasodilation and vascular leakage, which causes a rapid, precipitous and sustained decrease in arterial blood pressure with a concomitant decrease of cardiac output.
Shangze Gao, Shangze Gao, Shangze Gao, Keyue Liu, Wenhan Ku, Dengli Wang, Hidenori Wake, Handong Qiao, Kiyoshi Teshigawara, Masahiro Nishibori   +9 more
doaj   +1 more source

The Effect of H2 Receptor Antagonist in Acid Inhibition and Its Clinical Efficacy

The Korean Journal of Gastroenterology, 2017
The first histamine H2 receptor antagonists (H2RAs) were developed in the early 1970s. They played a dominant role in treating peptic ulcer disease and gastroesophageal reflux disease (GERD).
Young Kwang Shim, Nayoung Kim
doaj   +1 more source

Histamine release and fibrinogen adsorption mediate acute inflammatory responses to biomaterial implants in humans

Journal of Translational Medicine, 2007
Background Medical implants often fail as a result of so-called foreign body reactions during which inflammatory cells are recruited to implant surfaces.
Eaton John W, Zdolsek Johann, Tang Liping   +2 more
doaj   +1 more source

Role of Neuroinflammation in Autism Spectrum Disorder and the Emergence of Brain Histaminergic System. Lessons Also for BPSD?

Frontiers in Pharmacology, 2020
Many behavioral and psychological symptoms of dementia (BPSD) share similarities in executive functioning and communication deficits with those described in several neuropsychiatric disorders, including Alzheimer’s disease (AD), epilepsy, schizophrenia ...
Nermin Eissa, Nermin Eissa, Adel Sadeq, Astrid Sasse, Bassem Sadek, Bassem Sadek   +5 more
doaj   +1 more source