Results 61 to 70 of about 1,480,236 (218)
Histamine H3 Receptor Heterogeneity in the Central Nervous System in Aging and Dementia. [PDF]
, 2011 The histamine H3R is a classic G-protein coupled receptor and is a potential therapeutic target for a number of central nervous system pathologies. Major pharmacological heterogeneity between and within species has hindered the clinical development of ...
LETHBRIDGE, NATASHA,LOUSIE
core
British Journal of Pharmacology, Volume 183, Issue 20, Page 6007-6027, October 2026.Background and Purpose G protein‐coupled receptors (GPCRs) are integral membrane proteins that mediate physiological processes by enabling cells to detect and respond to diverse stimuli. Although many subfamily‐specific functional hotspots have been described, the family‐wide determinants of common and subfamily‐specific functions remain incomplete ...
Berkay Selçuk +3 more
wiley +1 more source
Histamine stimulates ciliary beat frequency via the H2 receptor in the protochordate Botryllus schlosseri [PDF]
, 2016 Histamine is a biogenic molecule that plays a role in many physiological pathways via binding to a specific receptor. Histaminergic receptors belong to the large family of seven-transmembrane α-helix domain receptors classified in mammals into four ...
Nicola Franchi +3 more
core +1 more source
Frontiers in Oncology, 2019 Cancer microenvironment is complex and consists of various immune cells. There is evidence for mast cell (MC) infiltration of tumors, but their role thereof is poorly understood.
Sandeep Paudel +2 more
doaj +1 more source
FEBS Open Bio, Volume 16, Issue 9, Page 1825-1839, September 2026.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Histamine H1- and H2-receptor vasodilation of canine intestinal circulation.
, 1977 Studies were conducted in anesthetized dogs to determine whether the mesenteric vasodilator response to histamine is mediated by H1 receptors alone or whether H2 receptors are also involved in the response.
B L Tepperman +4 more
core +1 more source
Permeability of rat IgE across rat aortic endothelial cell is enhanced by histamine
Allergology International, 2001 Background: It is a well-known fact that IgE is a key substance that induces an allergic reaction in extravascular tissue. However, it remains to be elucidated how IgE in the circulating blood transfers to the site of the allergic reaction in the ...
Kazuhiko Hanashiro +4 more
doaj +1 more source
Catheterization and Cardiovascular Interventions, Volume 108, Issue 3, Page 801-815, September 1, 2026.ABSTRACT Background The European Society of Cardiology (ESC) guidelines for peripheral artery disease recommend antithrombotic strategies based on high ischemic risk (HIR) and high bleeding risk (HBR) criteria. However, their prognostic value in patients with lower extremity artery disease (LEAD) undergoing endovascular therapy (EVT) remains unclear ...
Hirokazu Shimono +8 more
wiley +1 more source
Papel do receptor ativado por proteinases-2 (par-2) no comportamento de coçar em camundongos [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pos-Graduação em Farmacologia, Florianópolis, 2009.O objetivo do presente estudo foi investigar os possíveis mecanismos e mediadores envolvidos no
Costa, Robson da
core
, 2003 It is known that the activation of prejunctionally-located histamine H3 receptors down-regulates the exocytotic acetylcholine release from the myenteric plexus and thus produces a negative control on the intestinal motility [1].
POZZOLI, Cristina +7 more
core +1 more source