Results 41 to 50 of about 265,522 (247)

Is Deuterium Sequestering by Reactive Carbon Atoms an Important Mechanism to Reduce Deuterium Content in Biological Water?

FASEB BioAdvances
Deuterium is a natural heavy isotope of hydrogen, having a neutron as well as a proton. Deuterium disrupts ATP synthesis in mitochondria, causing increased production of reactive oxygen species and reduced synthesis of ATP.
Stephanie Seneff, Greg Nigh, Anthony M. Kyriakopoulos   +2 more
doaj   +1 more source

Reduced Muscular Carnosine in Proximal Myotonic Myopathy—A Pilot 1H‐MRS Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Myotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations such as diabetes mellitus, cataracts, and cardiac arrhythmias.
Alexander Gussew, Maryam Kargaran, Maik Rothe, Andreas Deistung, Dietrich Stoevesandt, Walter A. Wohlgemuth, David Strube, Thomas Kendzierski, Anna Katharina Kölsch, Maurits Gerhard Abraham Heuschen, Markus Otto, Alexander Mensch   +11 more
wiley   +1 more source

Unveiling the Molecular Signature of High-Temperature Cooking: Gas Chromatography-Mass Spectrometry Profiling of Sucrose and Histidine Reactions and Its Derivatives Induce Necrotic Death on THP1 Immune Cells

Chemistry
High-temperature cooking processes like frying, baking, smoking, or drying can induce chemical transformations in conventional food ingredients, causing deteriorative modifications.
Vaiyapuri Subbarayan Periasamy, Jegan Athinarayanan, Ali A. Alshatwi   +2 more
doaj   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

CRISPR/Cas9‐Assisted Microrobots for Fast and Ultrasensitive “On‐The‐Fly” Next‐Generation DNA Detection

Advanced Functional Materials, EarlyView.
This work presents self‐propelled CRISPR/Cas9‐functionalized Au–MRs for rapid, amplification‐free, “on‐the‐fly” DNA detection. By harnessing motion‐assisted signal recovery, the platform achieved the limit of detection in low fM DNA concentrations, enabling detection across a wide dynamic range within only 5 min, which is significantly faster than any ...
Jyoti, Petr Michálek, Zbyněk Heger, Martin Pumera   +3 more
wiley   +1 more source

Inflammation mediates the effect of histidine on a lower risk of colorectal cancer

Frontiers in Nutrition
BackgroundWhether anti-inflammatory mechanisms mediate the protective effects of histidine against colorectal carcinogenesis remains unexplored. We aimed to assess the association between plasma histidine and colorectal cancer (CRC) and to evaluate the ...
Chunlei He, Yudan Yang, Yudan Yang, Shuhui Chen, Bin Liu, Jing Guo, Ding Ye, Xiaohui Sun, Yingying Mao, Jiayu Li   +9 more
doaj   +1 more source

Reactivation of Serratia marcescens Endonuclease NucSma(H89G) by Hydroxilamine [PDF]

Учёные записки Казанского университета: Серия Естественные науки, 2017
Serratia marcescens endonuclease is the most nonspecific nuclease known. This nuclease refers to enzymes that can cleave both DNA and RNA. The active site of this enzyme is characterized by the H–N–H motif, but more important functions have been shown ...
R.G. Khamidullina, I.I. Fazleyeva, O.A. Gimadutdinow   +2 more
doaj  

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Evaluation of ruminal outflow of protein and nitrogen fractions, and total and individual essential amino acid predictions, by nutritional models in dairy cattle

Journal of Dairy Science
: The objective was to evaluate the fit statistics for the predictions of ruminal outflow of protein fractions and EAA by the NRC, National Academies of Sciences, Engineering, and Medicine (NASEM), Cornell Net Carbohydrate and Protein System (CNCPS), and
L.F. Martins, C.V. Almeida, Y. Kim, R.A. Patton, A.N. Hristov   +4 more
doaj   +1 more source

Design, Synthesis, and Evaluation of Homochiral Peptides Containing Arginine and Histidine as Molecular Transporters

Molecules, 2018
Linear (HR)n and cyclic [HR]n peptides (n = 4,5) containing alternate arginine and histidine residues were synthesized. The peptides showed 0–15% cytotoxicity at 5–100 µM in human ovarian adenocarcinoma (SK-OV-3) cells while they ...
Naglaa Salem El-Sayed, Taryn Miyake, Amir N. Shirazi, Shang Eun Park, Jimmy Clark, Stephani Buchholz, Keykavous Parang, Rakesh Tiwari   +7 more
doaj   +1 more source