Results 61 to 70 of about 164 (159)
Supramolecular Gels as Active Tools for Reaction Engineering
Angewandte Chemie, EarlyView.The unique combination of environments within gels, self‐assembled from low‐molecular‐weight gelators, offers the ability to control reactivity in new ways, achieving unique reaction outcomes, leading to the emerging concept of supramolecular gels as nanoreactors. Smart chemical engineering methods enable the use of such gels to fabricate materials and
David K. Smith
wiley +2 more sources
Aggregate, EarlyView.Cationic peptides aggregate citrate‐capped gold nanoparticles (AuNPs), producing a colorimetric change. The figure highlights the interplay between the intermolecular attractive and repulsive forces governing the colloidal stability of the nanoparticles.
Benjamin Lam +5 more
wiley +1 more source
Solving the Amyloid Paradox: Unveiling the Complex Pathogenicity of Amyloid Fibrils
Aggregate, EarlyView.This review addresses the gap between strong evidence for the involvement of amyloid fibrils in neurodegeneration and the failure of anti‐amyloid therapies, a phenomenon herein termed the “amyloid paradox.” To address this paradox, we provide a comprehensive summary of the current understanding of fibrils' pathogenic properties and mechanisms ...
Maksim I. Sulatsky +3 more
wiley +1 more source
Longitudinal Metabolomics in Amyotrophic Lateral Sclerosis Implicates Impaired Lipid Metabolism
Annals of Neurology, EarlyView.Objective Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by altered metabolome and energy homeostasis, manifesting with body mass index changes and hypermetabolism—both prognostic of disease progression and survival.
Kai Guo +7 more
wiley +1 more source
Angewandte Chemie, EarlyView.Human H ferritin (HuHf) is a nanocarrier for anticancer metal drugs. By cryo‐EM, a 1.51 Å structure of its adduct with Au(NHC)Cl was solved, showing a novel tetranuclear gold(I) cluster bound to Cys90 and Cys102. Short inter‐metal distances indicate aurophilic interactions.
Lucrezia Cosottini +9 more
wiley +2 more sources
The Comprehensive Roadmap Toward Malaria Elimination Using Graphene and its Promising 2D Analogs
Advanced NanoBiomed Research, EarlyView.Material based on a diversity of graphene with chemical properties of strong strength, high mobility, high transparency, good heat conductivity, biocompatibility, and chemical stability, advanced devices demonstrating antimalarial characteristics can be used for malaria treatment at different stages of malaria development from the injection of ...
Fangzhou He +11 more
wiley +1 more source
An Artificial Metal‐Free Peroxidase Designed Using a Ferritin Cage for Bioinspired Catalysis
Angewandte Chemie, EarlyView.Designing artificial enzymes remains challenging due to the need for precise active site control. Here, we present a simple strategy to create metal‐free artificial enzymes by engineering Histidine clusters inside a ferritin cage. The resulting catalyst mimics peroxidase activity, and its stable cage structure offers new insights into supramolecular ...
Jiaxin Tian +4 more
wiley +2 more sources
Angewandte Chemie, EarlyView.Through the directed evolution of an underexploited nonheme Fe extradiol dioxygenase, we developed a unified cooperative photobiocatalytic strategy to allow for three types of enantioconvergent radical transformations, including azidation, thiocyanation, and isocyanation.
Liu‐Peng Zhao +8 more
wiley +2 more sources
l-HISTIDINAL, A BIOSYNTHETIC PRECURSOR OF HISTIDINE
Journal of Biological Chemistry, 1955 openaire +3 more sources
Angewandte Chemie, EarlyView.Ein kleiner, aber entscheidender Unterschied: Typ‐III‐Kupferenzyme, wie Tyrosinasen (TYRs) und o‐Aminophenoloxidasen (AOs), katalysieren die Oxidation von o‐Aminophenolen (AP) zu Chinoniminen. Im Gegensatz zu TYRs können AOs AP weiter zu Nitrosophenolen oxidieren.
Hoa Le Xuan, Felix Panis, Annette Rompel
wiley +1 more source