Results 71 to 80 of about 291,783 (305)

Molecular Dynamics Simulations Based on Newly Developed Force Field Parameters for Cu²⁺ Spin Labels Provide Insights into Double-Histidine-Based Double Electron–Electron Resonance [PDF]

, 2020
Electron paramagnetic resonance (EPR) in combination with the recently developed double-histidine (dHis)-based Cu2+ spin labeling has provided valuable insights into protein structure and conformational dynamics.
Austin Gamble Jarvi (5184884), Xiaowei Bogetti (8626533), Junmei Wang (141197), Sunil Saxena (595882), Shreya Ghosh, Junmei Wang, Sunil Saxena, Xiaowei Bogetti, Austin Gamble Jarvi, Shreya Ghosh (5963075)   +9 more
core   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Effects of reduced metabolizable protein diets supplemented with rumen-protected His under adequate Met and Lys supply on production, nutrient digestibility, N utilization, and manure ammonia emissions in lactating cows

Journal of Dairy Science
: Balancing for limiting AA may prevent reduced production when deficient MP is provided. The objective of the study was to determine the effects of rumen-protected (RP) His supplementation at different levels of MP when Lys and Met supplies meet the ...
K. Park, J. Kim, H. Hu, M. Kambara, K. Nakagawa, C. Lee   +5 more
doaj   +1 more source

Histidine-Rich Cell-Penetrating Peptide for Cancer Drug Delivery and Its Uptake Mechanism [PDF]

, 2019
In this work, we report a drug delivery system based on the pH-responsive self-assembly and -disassembly behaviors of peptides. Here, a systematically designed histidine-rich lipidated peptide (NP1) is presented to encapsulate and deliver an anticancer ...
Feng Wang, Zhongzheng Gui (4537411), P. Chen, Lei Zhang (38117), Pingkai Ouyang, P. Chen (37301), Lei Zhang, Jiang Xu, Grace Jin, Yong Ding, Toby Wang, Pingkai Ouyang (1909729), Matthew Martz (6376295), Jiang Xu (351121), Feng Wang (44414), Grace Jin (6376292), Zhongzheng Gui, Matthew Martz, Toby Wang (6376289), Yong Ding (108968)   +19 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Global regulation and virulence mediated by the histidine-responsive local transcription factor HutC in Pseudomonas aeruginosa

mBio
Host-derived nutritional substrates fuel infection in invading bacteria, yet their potential as signaling molecules for host perception remains largely unexplored.
Kiran S. Jayan, Naran Naren, Yunhao Liu, Xinyi Liu, Chang Luan, Xue-Xian Zhang   +5 more
doaj   +1 more source

Histidine limitation alters plant development and influences the TOR network [PDF]

Plant growth depends on growth regulators, nutrient availability, and amino acid levels, all of which influence cell wall formation and cell expansion. Cell wall integrity and structures are surveyed and modified by a complex array of cell wall integrity
Levasseur, Caroline, Kadler, Gabor, Hou, Xiaoyu, Guerin, Amandine, Renggli, Dominik, Bigler, Laurent, Wicker, Thomas, Sotiropoulos, Alexandros, Meyer, Christian, Schaufelberger, Myriam, Ringli, Christoph, Herger, Aline   +11 more
core   +1 more source

Coordinative peptide recognition. Making intermolecular processes intramolecular [PDF]

, 2006
The design of synthetic receptors that function under physiological conditions is still a challenge. A successful strategy is the use of reversible coordination of Lewis-basic guest molecules to Lewis-acidic metal complexes to provide high and selective ...
Kruppa, Michael
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source