The critical structural role of a highly conserved histidine residue in group II amino acid decarboxylases [PDF]
, 2003 Glutamate decarboxylase is a pyridoxal 5′-phosphate (PLP)-dependent enzyme, belonging to the subset of PLP-dependent decarboxylases classified as group II.
Bossa, Francesco +4 more
core +1 more source
Proton transfer in histidine-tryptophan heterodimers embedded in helium droplets [PDF]
Journal of Chemical Physics 142, 114306 (2015), 2015 We used cold helium droplets as nano-scale reactors to form and ionize, by electron bombardment and charge transfer, aromatic amino acid heterodimers of histidine with tryptophan, methyl-tryptophan, and indole. The molecular interaction occurring through an N-H...N hydrogen bond leads to a proton transfer from the indole group of tryptophan to the ...
arxiv +1 more source
Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms [PDF]
, 2018 Platelet-activating factor (PAF) stimulates numerous cell types via activation of the G protein-coupled PAF receptor (PAFR). PAFR activation not only induces acute proinflammatory responses, but it also induces delayed systemic immunosuppressive effects ...
FitzGerald, Garret A. +6 more
core +1 more source
H-loop Histidine Catalyzes ATP Hydrolysis in the E. coli ABC-Transporter HlyB [PDF]
Phys. Chem. Chem. Phys. 2013, 15, 15811-15815, 2013 Adenosine triphosphate (ATP)-binding cassette (ABC) transporters form a family of molecular motor proteins that couple ATP hydrolysis to substrate translocation across cell membranes. Each nucleotide binding domain of ABC-transporters contains a highly conserved H-loop Histidine residue, whose precise mechanistic role to motor functions has remained ...
arxiv +1 more source
Structure and mechanism of acetolactate decarboxylase [PDF]
, 2013 Acetolactate decarboxylase catalyzes the conversion of both enantiomers of acetolactate to the (R)-enantiomer of acetoin, via a mechanism that has been shown to involve a prior rearrangement of the non-natural (R)-enantiomer substrate to the natural (S ...
Anand R. +36 more
core +1 more source
Diurnal fluctuation in the number of hypocretin/orexin and histamine producing: Implication for understanding and treating neuronal loss. [PDF]
, 2017 The loss of specific neuronal phenotypes, as determined by immunohistochemistry, has become a powerful tool for identifying the nature and cause of neurological diseases. Here we show that the number of neurons identified and quantified using this method
McGregor, Ronald +3 more
core +2 more sources
Structures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile [PDF]
, 2014 Tryptophan is an important precursor for chemical entities that ultimately support the biosynthesis of key metabolites. The second stage of tryptophan catabolism is catalysed by kynurenine formamidase, an enzyme that is different between eukaryotes and ...
Díaz-Sáez, Laura +3 more
core +4 more sources
Histidine decarboxylase-positive lactic acid bacteria strains and the formation of histamine in ripened cheeses [PDF]
, 2018 The relationship between histidine decarboxylase-positive (hdc+) lactic acid bacteria (LAB) counts and the amounts of biogenic amines, particularly histamine, in cheeses made with and without LAB starter were investigated. Sixty LAB strains were isolated
Carbó Moliner, Rosa +3 more
core +2 more sources
mBio, 2015 Probiotics and commensal intestinal microbes suppress mammalian cytokine production and intestinal inflammation in various experimental model systems.
Chunxu Gao +7 more
doaj +1 more source
Life, 2022 Allergic rhinitis (AR) affects 20–50% of the global population. Available treatments are limited by their adverse effects. We investigated the anti-allergic effects of catechin alone and combined with cetirizine against ovalbumin-induced AR.
Mohamed A. Morsy +7 more
doaj +1 more source