Results 111 to 120 of about 135,178 (348)
Chemistry &Biodiversity, EarlyView.ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves +3 more
wiley +1 more source
Histidine Phosphorylation: Protein Kinases and Phosphatases
International Journal of Molecular SciencesPhosphohistidine (pHis) is a reversible protein post-translational modification (PTM) that is currently poorly understood. The P-N bond in pHis is heat and acid-sensitive, making it more challenging to study than the canonical phosphoamino acids pSer, pThr, and pTyr. As advancements in the development of tools to study pHis have been made, the roles of
Jia Ning +5 more
openaire +2 more sources
Genistein inhibits protein histidine kinase.
Journal of Biological Chemistry, 1992 Protein histidine kinase was prepared from whole cell extracts of the yeast, Saccharomyces cerevisiae. The enzyme was assayed using either histone H4 or a synthetic peptide corresponding to residues 70 to 102 of histone H4 as an in vitro substrate. With either substrate, both genistein and its solvent, dimethyl sulfoxide (Me2SO), inhibited protein ...
Jianmin Huang +3 more
openaire +3 more sources
ChemBioChem, EarlyView.Cyclometalated gold(III) complexes offer a versatile platform for selective biological interactions, including cysteine arylation, redox modulation, and enzyme inhibition. This review explores their roles in anticancer, antimicrobial, and protein modification strategies, highlighting their ability to disrupt metabolic pathways, modulate aquaporins, and
Sophie R. Thomas, Riccardo Bonsignore
wiley +1 more source
Engineered Exosome‐Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia
Exploration, EarlyView.We identified a harmful immune cell type, p21+CD86+ microglia, driving post‐stroke inflammation and developed a targeted exosome‐based therapy (Que@micro‐Exo) to eliminate these cells. This innovative treatment reduced inflammation, alleviated brain damage, and improved recovery in stroke models, offering a promising strategy for stroke and other ...
Jialei Yang, Shipo Wu, Miao He
wiley +1 more source
Food Frontiers, EarlyView.Nutraceutical Potential in Disease Mitigation and Health Enhancement of Actinidia spp. (Kiwifruit) ABSTRACT This review offers an in‐depth exploration of the Actinidia species (kiwifruit) nutritional composition, the pivotal role of its primary bioactive compounds, and their potential applications across the aforementioned health concerns. Furthermore,
Allah Rakha +7 more
wiley +1 more source
Segmental helical motions and dynamical asymmetry modulate histidine kinase autophosphorylation.
PLoS Biology, 2014 Histidine kinases (HKs) are dimeric receptors that participate in most adaptive responses to environmental changes in prokaryotes. Although it is well established that stimulus perception triggers autophosphorylation in many HKs, little is known on how ...
Ariel E Mechaly +3 more
doaj +1 more source
Positive surface charge of GluN1 N-terminus mediates the direct interaction with EphB2 and NMDAR mobility. [PDF]
, 2020 Localization of the N-methyl-D-aspartate type glutamate receptor (NMDAR) to dendritic spines is essential for excitatory synaptic transmission and plasticity.
Dalva, Matthew B. +4 more
core +1 more source
The cyclic AMP phosphodiesterase RegA critically regulates encystation in social and pathogenic amoebas [PDF]
, 2014 Amoebas survive environmental stress by differentiating into encapsulated cysts. As cysts, pathogenic amoebas resist antibiotics, which particularly counteracts treatment of vision-destroying Acanthamoeba keratitis. Limited genetic tractability of amoeba
Birgersson, Elin +5 more
core +2 more sources
An investigation into the transcription factors and regulatory mechanisms of Aspergillus
Food Safety and Health, EarlyView.Foodborne pathogen Aspergillus, a prevalent etiologic agent among filamentous fungi, are distinguished by a significant repertoire of transcription factors encoded within their genomes. These regulatory proteins are instrumental in orchestrating key biological processes, including cellular growth, secondary metabolite biosynthesis, mycotoxin production,
Yuxin Qin, Huawei Yu, Jun Tian
wiley +1 more source