Results 141 to 150 of about 135,178 (348)
A Novel Bis-Coumarin Targets Multiple Tyrosine Kinases of Key Signaling Pathways in Melanoma and Inhibits Melanoma Cell Survival, Proliferation, and Migration [PDF]
arXiv, 2020 Melanoma is one of the most dangerous skin malignancies due to its high metastatic tendency and high mortality. Activation of key signaling pathways enforcing melanoma progression depends on phosphorylation of tyrosine kinases, and oxidative stress. We here investigated the effect of the new bis-coumarin derivative (3,5-DCPBC) on human melanoma cell ...
arxiv
Autophosphorylation by the Histidine kinase CheA (LB222)
The FASEB Journal, 2014 Chemotaxis is the signal transduction mechanism that allows bacteria to change direction in response to an external stimulus. Detection of an environmental stimulus by the receptors has a cascading effect leading to the flagellar motor changing direction. This results in the tumbling of the bacterium.
Brian R. Crane, Anna R. Greenswag
openaire +2 more sources
The DNA Binding Properties of the Parsley bZIP Transcription Factor CPRF4a Are Regulated by Light [PDF]
, 2001 The common plant regulatory factors (CPRFs) from parsley are transcription factors with a basic leucine zipper motif that bind to cis-regulatory elements frequently found in promoters of light-regulated genes.
Harter, Klaus +2 more
core
ChemistryOpen, EarlyView.Tau protein aggregation and fibrillation have been examined in relationship to three metal ions in this study. The research was conducted to see the effects of Zn2+, Cu2+ and Fe3+ ions at different concentrations on tau′s conformation, cytotoxicity in SH‐SY5Y cells, and free thiol levels.
Mahzad Irandoust +6 more
wiley +1 more source
Quantifying the efficiency of principal signal transmission modes in proteins [PDF]
arXivOn the microscopic level, biological signal transmission relies on coordinated structural changes in allosteric proteins that involve sensor and effector modules. The timescales and microscopic details of signal transmission in proteins are often unclear, despite a plethora of structural information on signaling proteins.
arxiv
General and Specific Promotion of Flagellar Assembly by a Flagellar Nucleoside Diphosphate Kinase [PDF]
, 2017 Nucleoside diphosphate kinases (NDKs) play a central role in diverse cellular processes using the canonical NDK activity or alternative mechanisms that remain poorly defined.
Ciruelas, Kristine S. +9 more
core +1 more source
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT ZraS is a metal sensor integral to ZraPSR, a two‐component signaling system found in enterobacters. It belongs to a family of bifunctional sensor histidine kinases (SHKs) and is speculated to sense zinc‐induced stress on the bacterial envelope.
Nilima Mahapatra +3 more
wiley +1 more source
Site‐directed mutagenesis of histidine 62 in the ‘basic patch’ region of yeast phosphoglycerate kinase [PDF]
, 1989 Wayne J. Fairbrother +5 more
openalex +1 more source
ARR1 and AHP interactions in the multi-step phosphorelay system
Frontiers in Plant SciencePlants use multi-step phosphorelay (MSP) systems in response to exogenous and endogenous stimuli. Cytokinin and ethylene are among the factors that engage MSP signaling cascades but examples independent of phytohormones also exist.
Linh H. Tran, Milosz Ruszkowski
doaj +1 more source
Small Methods, EarlyView.Harnessing synthetic key receptor modulators, this study presents a breakthrough in Wnt/β‐catenin regulation. The FZD agonist RRP‐pbFn bypasses LRP5/6 to drive organoid expansion and tissue regeneration, while the LRP antagonist RRP‐Dkk1c eradicates tumors. These tools enable precise pathway control, advancing regenerative and cancer therapies.
Quanhui Dai +9 more
wiley +1 more source