Results 151 to 160 of about 82,686 (281)

A sensor histidine kinase from a plant-endosymbiont bacterium restores the virulence of a mammalian intracellular pathogen. [PDF]

Microb Pathog, 2023
Chaves-Olarte E, Meza-Torres J, Herrera-Rodríguez F, Lizano-González E, Suárez-Esquivel M, Baker KS, Rivas-Solano O, Ruiz-Villalobos N, Villalta-Romero F, Cheng HP, Walker GC, Cloeckaert A, Thomson NR, Frisan T, Moreno E, Guzmán-Verri C.   +15 more
europepmc   +1 more source

Chemical Profiling, In Silico and In Vitro Studies to Identify Potential CDK2 and mTOR Inhibitor From Selaginella inaequalifolia (Hook. & Grev.) Spring Ethanolic Extracts

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
ABSTRACT The current study is aimed to reveal the phytoprofile of Selaginella inaequalifolia (Hook. & Grev.) Spring using GC–MS and predict the drug properties, toxicity, biological properties of S. inaequalifolia ethanolic extracts (SiEE) using in silico methods and in vitro toxicity assays, namely, MTT and BSLB assay.
Johnson Marimuthu Alias Antonysamy, Sivaraman Arumugam, Robin Charles Antony Arulraj, Anne Wincy Jacob Thomas, Henrique D. M. Coutinho   +4 more
wiley   +1 more source

An HWE-Family Histidine Kinase Modulates Brucella Cell Envelope Properties and Host Innate Immune Response. [PDF]

Mol Microbiol
Chen X, Perez E, Scheeres EC, Northcote R, Fiebig A, Olive AJ, Crosson S.   +6 more
europepmc   +1 more source

In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug Transporters

The Journal of Clinical Pharmacology, Volume 66, Issue 2, February 2026.
Abstract Bemnifosbuvir is a novel oral guanosine nucleotide prodrug candidate for the treatment of chronic hepatitis C virus infection. Potential drug–drug interactions (DDIs) of bemnifosbuvir as a substrate or perpetrator with regard to ATP‐binding cassette (ABC) and solute carrier (SLC) transporters were evaluated in vitro and in clinical studies ...
Xiao‐Jian Zhou, Alex Vo, Gaetano Morelli, Maureen Montrond, Shannan Lynch, Keith Pietropaolo, Bruce Belanger, Arantxa Horga, Nancy Agrawal, Janet Hammond   +9 more
wiley   +1 more source

Insights Into the Conformational Dynamics of the Cytoplasmic Domain of Metal-Sensing Sensor Histidine Kinase ZraS. [PDF]

Proteins
Mahapatra N, Mahanta P, Pandey S, Acharya R.   +3 more
europepmc   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Evidence of bidirectional transmembrane signaling by the sensor histidine kinase GacS from Pseudomonas aeruginosa. [PDF]

J Biol Chem
Salar S, Silletti S, Schubot FD.
europepmc   +1 more source

Mutational Analysis of the Ethylene Receptor ETR1. Role of the Histidine Kinase Domain in Dominant Ethylene Insensitivity [PDF]

, 2002
Rebekah L. Gamble, Xiang Qu, G. Eric Schaller   +2 more
openalex   +1 more source

Tetravalent antibodies are more potent and efficacious erythropoiesis‐stimulating agents than erythropoietin in vivo

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Recent studies have shown that tetravalent antibodies are potent and efficacious agonists of the erythropoietin (EPO) receptor (EPOR) both in vitro and in vivo. To identify antibody‐based erythropoiesis‐stimulating agents (ESAs) with therapeutic potential, we evaluated various tetravalent antibody formats for EPOR agonism and key biophysical ...
Jarrett J. Adams, Levi L. Blazer, Jacky Chung, Minoo Karimi, Taylor Davidson, Bailey Blair, Carlos Waddle, Craig A. Hokanson, Heather A. Bruce, Alexander U. Singer, Eva‐Maria Tombak, Kiira Gildemann, Nele Tamberg, Kaja Kiiver, Mart Ustav Jr, Yue Ma, Luigi Colombo, Lily Jun‐Shen Huang, Stephen W. Michnick, Orson W. Moe, Sachdev S. Sidhu   +20 more
wiley   +1 more source

Direct sensing of host ferric iron by an archetype histidine kinase mediates virulence of an enteric pathogen. [PDF]

Proc Natl Acad Sci U S A
Zhang Y, Xiao G, Ding H, Zou Q, Gu D, Wen J, Pei Y, Guo R, Wang Q, Zhou X.   +9 more
europepmc   +1 more source