Results 171 to 180 of about 82,686 (281)

Molecular mechanisms of plant NLR activation and signalling

The Plant Journal, Volume 125, Issue 3, February 2026.
SUMMARY Plants rely on NLRs (nucleotide‐binding leucine‐rich repeat receptors) to recognise effector proteins secreted by pathogens into plant cells and to deliver disease resistance. Plant NLRs are broadly characterised by their N‐terminal domains, which include the TIR (Toll/interleukin‐1 receptor) and the CC (coiled‐coil) domains.
Natsumi Maruta, Mitchell Sorbello, Laura Garzon‐Flores, Bostjan Kobe   +3 more
wiley   +1 more source

The VanS sensor histidine kinase from type-B vancomycin-resistant enterococci recognizes vancomycin directly. [PDF]

J Biol Chem
Maciunas LJ, Rotsides P, D'Lauro EJ, Brady S, Beld J, Loll PJ.   +5 more
europepmc   +1 more source

A chemosensory-like histidine kinase is dispensable for chemotaxis in vitro but regulates the virulence of Borrelia burgdorferi through modulating the stability of RpoS. [PDF]

PLoS Pathog, 2023
Sze CW, Zhang K, Lynch MJ, Iyer R, Crane BR, Schwartz I, Li C.   +6 more
europepmc   +1 more source

Serine/threonine kinase activity in the putative histidine kinase‐like ethylene receptor NTHK1 from tobacco [PDF]

, 2003
Can Xie, Jin‐Song Zhang, Hua‐Lin Zhou, Jian Li, Zhigang Zhang, Dao Wen Wang, Shou‐Yi Chen   +6 more
openalex   +1 more source

Unlocking the Therapeutic Potential of Integrin‐Linked Kinase Inhibitors in Bioengineered 3D Breast Tumor Stroma Models

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
3D cancer models provide a more reliable representation of drug responses compared to 2D cell culture owing to their 3D architecture and facilitation of cell‐extracellular matrix interactions. In this study, we engineered dense compartmentalized 3D tumoroids composed of breast tumor mass and a surrounding stromal compartment replicating either breast ...
Salma T. Rafik, Anuja Upadhyay, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Combined transcriptome and metabolome analysis reveals the regulatory network of histidine kinase QseC in the two-component system of <i>Glaesserella parasuis</i>. [PDF]

Front Microbiol
Yan X, Zhou Y, Liu S, Gu C, Xiao W, Zhao M, Yu Z, He L.   +7 more
europepmc   +1 more source

The Sensory Histidine Kinase CusS of Escherichia coli Senses Periplasmic Copper Ions. [PDF]

Microbiol Spectr, 2023
Rismondo J, Große C, Nies DH.
europepmc   +1 more source

Gezielte Modulation des spliceosomalen Proteins USP39 durch allosterische Liganden und PROTAC‐induzierte Degradation

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Proteolysis‐targeting Chimeras (PROTACs) ermöglichen die gezielte Degradation bislang als „undruggable“ geltende Proteine über das zelluläre Ubiquitin–Proteasom‐System. In dieser Studie identifizieren Schäfer et al. thiazolbasierte niedermolekulare Liganden, die allosterisch an die Zinkfinger‐Domäne der Ubiquitin‐spezifischen Protease 39 (USP39) binden
Daniel Schäfer, Cristian Prieto‐Garcia, Jianhui Wang, Marcel Heinz, Vigor Matkovic, Pavel Kielkowski, Sebastian Hasselbeck, Varun Jayeshkumar Shah, Stefan Knapp, Gerhard Hummer, Ivan Dikic, Xinlai Cheng   +11 more
wiley   +1 more source

The PAS domain of the polarly localized histidine kinase FlrB in <i>Vibrio cholerae</i> controls class III flagellar transcription and contributes to intestinal colonization. [PDF]

mBio
Stanton V, Himes B, Mejia-Santana A, Eppinger M, Romo J, Xing J, Zhulin IB, Cai H, Wang Y, Inniss Nl, Minasov G, Satchell KJF, Klose KE.   +12 more
europepmc   +1 more source

NH125 Sensitizes Staphylococcus aureus to Cell Wall-Targeting Antibiotics through the Inhibition of the VraS Sensor Histidine Kinase. [PDF]

Microbiol Spectr, 2023
Bhattarai S, Marsh L, Knight K, Ali L, Gomez A, Sunderhaus A, Abdel Aziz MH.   +6 more
europepmc   +1 more source