Cell Cycle Control by Xenopus p28^(Kix1) a Developmentally Regulated Inhibitor of Cyclin-dependent Kinases [PDF]
We have isolated Xenopus p28^(Kix1), a member of the p21^(CIP1)/p27^(KIP1)/p57^(KIP2) family of cyclin-dependent kinase (Cdk) inhibitors. Members of this family negatively regulate cell cycle progression in mammalian cells by inhibiting the activities of
Dunphy, William G., Shou, Wenying
core
Extraocular Photoreception in Optic Lobes, Suckers, and Skin of Octopus vulgaris
Evidence of extra‐ocular photoreception in Octopus vulgaris (a) Diagram of the O. vulgaris different tissues considered: SPB, sucker proximal big; SPL, sucker proximal large; SM, sucker medium; SD, sucker distal; SK, skin; OL, optic lobes; RT, retina; (b‐d) Gene expression analysis of Ov‐GRK1 (red), Ov‐retinochrome (green), Ov‐rhodopsin (blue) mRNA ...
Valeria Maselli+7 more
wiley +1 more source
The Role of Histidines in the Acetate Kinase fromMethanosarcina thermophila [PDF]
Cheryl Ingram‐Smith+2 more
openalex +1 more source
Identification of direct residue contacts in protein-protein interaction by message passing
Understanding the molecular determinants of specificity in protein-protein interaction is an outstanding challenge of postgenome biology. The availability of large protein databases generated from sequences of hundreds of bacterial genomes enables ...
Altschuh+29 more
core +2 more sources
Abstract Background and Purpose The C‐type lectin‐like receptor‐2 (CLEC‐2) is a platelet receptor for the endogenous ligand podoplanin. This interaction contributes to several (patho)physiological processes, such as lymphangiogenesis, preservation of blood and lymphatic vessel integrity organ development, and tumour metastasis.
Marcin A. Sowa+8 more
wiley +1 more source
The histidine kinase-related domain participates in phytochrome B function but is dispensable [PDF]
Leonard Krall, Jason W. Reed
openalex +1 more source
Allosteric coupling activation mechanism in histidine kinases
Histidine kinases (HKs) are crucial regulators of cellular functions, mediating the phosphorylation of specific proteins to modulate their activity and localization. Upon signal detection, HKs transfer a phosphate group from ATP to a conserved histidine residue within their Dimerization and Histidine phosphotransfer domain, subsequently passing the ...
Juan Cruz Almada+5 more
openaire +3 more sources
Diatom triacylglycerol metabolism: from carbon fixation to lipid droplet degradation
ABSTRACT Diatoms are a prominent microalgae family that has attracted interest for its production of molecules of biotechnological interest. Their fatty acid profile is rich in health‐beneficial omega‐3 eicosapentaenoic acid (EPA). Furthermore, under nutrient‐deprived conditions, many diatom species, notably Phaeodactylum tricornutum, Thalassiosira ...
Victor Murison+3 more
wiley +1 more source
Helicobacter pylori Activates the Histidine Decarboxylase Promoter through a Mitogen-activated Protein Kinase Pathway Independent of Pathogenicity Island-encoded Virulence Factors [PDF]
Silja Weßler+8 more
openalex +1 more source
The Role of Histone Methyltransferase SETDB1 in Normal and Malignant Hematopoiesis
In this review, we discuss the role of SETDB1 in gene regulation, including an overview of its structural features and key cofactors. We also highlight the lineage‐specific roles of SETDB1 in both normal hematopoietic processes and hematological malignancies, emphasizing its function as an immune checkpoint molecule that suppresses natural killer cell ...
Yu‐Hsuan Chang, Susumu Goyama
wiley +1 more source