Classification of Platelet‐Activating Anti‐Platelet Factor 4 Disorders
ABSTRACT Introduction The prototypic anti‐platelet factor 4 (PF4) disorder—heparin‐induced thrombocytopenia and thrombosis (HITT)—features immunoglobulin G (IgG) class antibodies that activate platelets, monocytes, and neutrophils in a mainly heparin‐dependent fashion via Fcγ receptor‐dependent cellular activation.
Theodore E. Warkentin
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Genetic Analysis of the His-to-Asp Phosphorelay Implicated in Mitotic Cell Cycle Control: Involvement of Histidine-Kinase Genes of Schizosaccharomyces pombe [PDF]
Keisuke Aoyama+2 more
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Comparative analysis of the molecular starvation response of Southern Ocean copepods
Abstract Large lipid‐storing copepods dominate mesozooplankton biomass in the polar oceans and form a critical link between primary production and higher trophic levels. The ecological success of these species depends on their ability to survive periods of food deprivation in a highly seasonal environment, but the molecular changes that mediate ...
Cory A. Berger+3 more
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SdeK, a Histidine Kinase Required for Myxococcus xanthus Development [PDF]
Jeffrey S. Pollack, Mitchell Singer
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Porphyromonas gingivalis exports several virulent proteins, including gingipain proteinases, via the type 9 secretion system. Expression of several T9SS component proteins is regulated by the PorA‐PorY‐PoX‐SigP signaling cascade. This study presents a novel role of PorA in the signaling cascade.
Momoko Ito+9 more
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HstK, a cyanobacterial protein with both a serine/threonine kinase domain and a histidine kinase domain: implication for the mechanism of signal transduction [PDF]
Vincent Phalip+2 more
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A chemosensory-like histidine kinase is dispensable for chemotaxis in vitro but regulates the virulence of Borrelia burgdorferi through modulating the stability of RpoS. [PDF]
Sze CW+6 more
europepmc +1 more source
Iron is essential for life, yet excessive levels can quickly lead to cellular damage via oxidative stress, underscoring the need for global regulators of iron and heme homeostasis. In this study, we present a genome‐wide analysis of the binding patterns of DtxR and HrrA in Corynebacterium glutamicum.
Aileen Krüger+2 more
wiley +1 more source
Myxococcus xanthus mokA Encodes a Histidine Kinase-Response Regulator Hybrid Sensor Required for Development and Osmotic Tolerance [PDF]
Yoshio Kimura+3 more
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Interdomain Linkers Regulate Histidine Kinase Activity by Controlling Subunit Interactions. [PDF]
Maschmann Z+3 more
europepmc +1 more source