Results 71 to 80 of about 1,192,564 (261)

Mechanism of Regulation of Receptor Histidine Kinases [PDF]

Structure, 2012
Bacterial transmembrane receptors regulate an intracellular catalytic output in response to extracellular sensory input. To investigate the conformational changes that relay the regulatory signal, we have studied the HAMP domain, a ubiquitous intracellular module connecting input to output domains.
Ferris, Hedda U., Dunin-Horkawicz, Stanislaw, Hornig, Nora, Hulko, Michael, Schultz, Joachim E., Zeth, Kornelius, Lupas, Andrei N., Coles, Murray, Martin, Jörg   +8 more
openaire   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Recombinant Cytosolic Truncations of Histidine Kinases Retain Function for Targeted In Vitro Investigations

Microorganisms
Histidine kinases are an integral component of bacterial two-component systems (TCSs), playing a pivotal role in signal transduction pathways, resulting in both resistance and virulence. However, their inherent membrane-bound nature often results in poor
Jude Kinkead, Alexander D. Hondros, Aimee M. Figg, Milah M. Young, Richele J. Thompson, Christian Melander, John Cavanagh   +6 more
doaj   +1 more source

Proteolysis and multimerization regulate signaling along the two-component regulatory system AdeRS

iScience, 2021
Summary: Bacterial two-component regulatory systems are ubiquitous environment-sensing signal transducers involved in pathogenesis and antibiotic resistance.
Zhenlin Ouyang, Fang Zheng, Li Zhu, Jan Felix, Di Wu, Ke Wu, Irina Gutsche, Yi Wu, Peter M. Hwang, Junjun She, Yurong Wen   +10 more
doaj   +1 more source

Proteolysis of histidine kinase VgrS inhibits its autophosphorylation and promotes osmostress resistance in Xanthomonas campestris

Nature Communications, 2018
In bacterial cells, histidine kinases (HKs) are receptors that monitor environmental and intracellular stimuli. HKs and their cognate response regulators constitute two-component signalling systems (TCSs) that modulate cellular homeostasis through ...
Chao-Ying Deng, Huan Zhang, Yao Wu, L. Ding, Yue Pan, Shu-Tao Sun, Yajun Li, Li Wang, W. Qian   +8 more
semanticscholar   +1 more source

Phytochrome: If It Looks and Smells Like a Histidine Kinase, Is It a Histidine Kinase? [PDF]

Cell, 1997
That's all fine and good for cyanobacterial phytochrome, but the real excitement has to do with potential functional homology of plant phytochromes. Specifically, do plant phytochromes possess histidine kinase activity and what then do we make of phytochrome-associated serine kinase activity? As discussed by Quail 1997xQuail, P.H. BioEssay.
Elich, Tedd D, Chory, Joanne
openaire   +2 more sources

Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes. [PDF]

, 2019
Wilson disease (WD) is a genetic copper overload condition characterized by hepatic and neuropsychiatric symptoms with a not well-understood pathogenesis.
Czlonkowska, Anna, Kim, Kyoungmi, Litwin, Tomasz, Mazi, Tagreed A, Medici, Valentina, Sarode, Gaurav V, Shibata, Noreene M   +6 more
core   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Role of the PAS2 domain of the NifL regulatory protein in redox signal transduction [PDF]

, 2010
EThOS - Electronic Theses Online ServiceGBUnited ...
Slavny, Peter
core  

Substitutions in the redox-sensing PAS domain of the NifL regulatory protein define an inter-subunit pathway for redox signal transmission [PDF]

, 2011
The Per-ARNT-Sim (PAS) domain is a conserved a/ß fold present within a plethora of signalling proteins from all kingdoms of life. PAS domains are often dimeric and act as versatile sensory and interaction modules to propagate environmental signals to ...
Ayers, Campbell, Demeler, Dixon, Hefti, Hill, Karimova, Key, Kurokawa, Little, Little, Little, Ma, Macheroux, Martinez-Argudo, Matthews, Miyatake, Money, Möglich, Möglich, Möglich, Nan, Perry, Qi, Reyes-Ramirez, Reyes-Ramirez, Slavny, Söderbäck, Taylor, Ukaegbu, Watts, Williamson, Zhou, Zoltowski, Zoltowski   +34 more
core   +1 more source