Results 61 to 70 of about 249,831 (220)

Computer‐aided Evaluation of Polyvalent Medications’ Pharmacological Potential. Multiphytoadaptogen as a Case Study

Molecular Informatics, Volume 42, Issue 1, January 2023., 2023
Abstract Many human diseases including cancer, degenerative and autoimmune disorders, diabetes and others are multifactorial. Pharmaceutical agents acting on a single target do not provide their efficient curation. Multitargeted drugs exhibiting pleiotropic pharmacological effects have certain advantages due to the normalization of the complex ...
O. A. Bocharova, N. S. Ionov, I. V. Kazeev, V. E. Shevchenko, E. V. Bocharov, R. V. Karpova, O. P. Sheychenko, A. A. Aksyonov, S. V. Chulkova, V. G. Kucheryanu, A. V. Revishchin, G. V. Pavlova, V. S. Kosorukov, D. A. Filimonov, A. A. Lagunin, V. B. Matveev, N. V. Pyatigorskaya, I. S. Stilidi, V. V. Poroikov   +18 more
wiley   +1 more source

Association of Histo–Blood Group Antigens and Susceptibility to Norovirus Infections [PDF]

The Journal of Infectious Diseases, 2005
Noroviruses (NoVs) are the leading cause of viral gastroenteritis in humans of all ages. Challenge studies that used the NoV prototype strain Norwalk virus (NV) have shown that some individuals are not susceptible to infection, suggesting the absence of a receptor. Recent studies have identified histo-blood group antigens (HBGAs) as possible receptors.
Marion Koopmans, Christian J. P. A. Hoebe, Harry Vennema, Erwin Duizer, Barry Rockx   +4 more
openaire   +3 more sources

Norovirus diarrhea is significantly associated with higher counts of fecal histo-blood group antigen expressing Enterobacter cloacae among black South African infants

Gut Microbes, 2021
The study tested the hypothesis that harboring high levels of histo-blood group antigen-expressing Enerobactero cloacae is a risk factor for norovirus diarrhea. The fecal E. cloacae abundance in diarrheic norovirus positive (DNP), non-diarrheic norovirus
Cliff A Magwira, Duncan Steele, ML Seheri   +2 more
doaj   +1 more source

Intestinal mucin-type O-glycans: the major players in the host-bacteria-rotavirus interactions

Gut Microbes, 2023
Rotavirus (RV) causes severe diarrhea in young children and animals worldwide. Several glycans terminating in sialic acids (SAs) and histo-blood group antigens (HBGAs) on intestinal epithelial cell (IEC) surface have been recognized to act as attachment ...
S.A. Raev, J.O. Amimo, L.J. Saif, A.N. Vlasova   +3 more
doaj   +1 more source

Genetic Susceptibility to Human Norovirus Infection: An Update

Viruses, 2019
Noroviruses are the most common etiological agent of acute gastroenteritis worldwide. Despite their high infectivity, a subpopulation of individuals is resistant to infection and disease. This susceptibility is norovirus genotype-dependent and is largely
Johan Nordgren, Lennart Svensson
doaj   +1 more source

ABO blood groups and expression of blood group antigens of epithelial ovarian cancer in Chinese women

Cancer Medicine, 2023
Background ABO blood groups has been associated with risk of several cancers; however, the results for an association with ovarian cancer are inconsistent and little is known about the expression of histo‐blood group (ABH) antigens and ABO gene in ...
Chao Wang, Jingjing Zhou, Lili Wang, Tongyu Xing, Hongji Dai, Yao Zhou, Lisha Qi, Yanrui Zhao, Caiyun Huang, Ding Li, Haixin Li, Mulin Jun Li, Ben Liu, Hong Zheng, Kexin Chen, Lian Li   +15 more
doaj   +1 more source

Intestinal shedding of enteric agents in histo-blood group antigen-secretor children in an Australian community-based birth cohort study

Journal of Pediatric and Neonatal Individualized Medicine, 2022
Histo-blood group antigens are inherited polymorphic glycans expressed on mucosal epithelial cell surfaces and shed in secretions. They act as receptors for gastrointestinal pathogens. Those expressing these antigens are categorized as secretors and have
Gabor Mihala, Robert S. Ware, Catherine Cheung, Stephen B. Lambert, Peter D. Sly, David M. Whiley, Keith Grimwood   +6 more
doaj   +1 more source

Binding to histo-blood group antigen-expressing bacteria protects human norovirus from acute heat stress

Frontiers in Microbiology, 2015
This study aims to investigate if histo-blood group antigen (HBGA) expressing bacteria have any protective role on human norovirus (NoV) from acute heat stress.
Dan eLi, Adrien eBreiman, Adrien eBreiman, Adrien eBreiman, Adrien eBreiman, Jacques eLe Pendu, Jacques eLe Pendu, Jacques eLe Pendu, Mieke eUyttendaele   +8 more
doaj   +1 more source

Species-Specific N-Glycomes and Methylation Patterns of Oysters Crassostrea gigas and Ostrea edulis and Their Possible Consequences for the Norovirus–HBGA Interaction

Marine Drugs, 2023
Noroviruses, the major cause of acute viral gastroenteritis, are known to bind to histo-blood group antigens (HBGAs), including ABH groups and Lewis-type epitopes, which decorate the surface of erythrocytes and epithelial cells of their host tissues. The
Audrey Auger, Shin-Yi Yu, Shih-Yun Guu, Agnès Quéméner, Gabriel Euller-Nicolas, Hiromune Ando, Marion Desdouits, Françoise S. Le Guyader, Kay-Hooi Khoo, Jacques Le Pendu, Frederic Chirat, Yann Guerardel   +11 more
doaj   +1 more source

Immune Imprinting Drives Human Norovirus Potential for Global Spread

mBio, 2022
Understanding the complex interactions between virus and host that drive new strain evolution is key to predicting the emergence potential of variants and informing vaccine development. Under our hypothesis, future dominant human norovirus GII.4 variants
Lisa C. Lindesmith, Florencia A. T. Boshier, Paul D. Brewer-Jensen, Sunando Roy, Veronica Costantini, Michael L. Mallory, Mark Zweigart, Samantha R. May, Helen Conrad, Kathleen M. O’Reilly, Daniel Kelly, Cristina C. Celma, Stuart Beard, Rachel Williams, Helena J. Tutill, Sylvia Becker Dreps, Filemón Bucardo, David J. Allen, Jan Vinjé, Richard A. Goldstein, Judith Breuer, Ralph S. Baric   +21 more
doaj   +1 more source