Results 61 to 70 of about 6,935 (192)

Intestinal shedding of enteric agents in histo-blood group antigen-secretor children in an Australian community-based birth cohort study

Journal of Pediatric and Neonatal Individualized Medicine, 2022
Histo-blood group antigens are inherited polymorphic glycans expressed on mucosal epithelial cell surfaces and shed in secretions. They act as receptors for gastrointestinal pathogens. Those expressing these antigens are categorized as secretors and have
Gabor Mihala, Robert S. Ware, Catherine Cheung, Stephen B. Lambert, Peter D. Sly, David M. Whiley, Keith Grimwood   +6 more
doaj   +1 more source

Immune Imprinting Drives Human Norovirus Potential for Global Spread

mBio, 2022
Understanding the complex interactions between virus and host that drive new strain evolution is key to predicting the emergence potential of variants and informing vaccine development. Under our hypothesis, future dominant human norovirus GII.4 variants
Lisa C. Lindesmith, Florencia A. T. Boshier, Paul D. Brewer-Jensen, Sunando Roy, Veronica Costantini, Michael L. Mallory, Mark Zweigart, Samantha R. May, Helen Conrad, Kathleen M. O’Reilly, Daniel Kelly, Cristina C. Celma, Stuart Beard, Rachel Williams, Helena J. Tutill, Sylvia Becker Dreps, Filemón Bucardo, David J. Allen, Jan Vinjé, Richard A. Goldstein, Judith Breuer, Ralph S. Baric   +21 more
doaj   +1 more source

A New Chemical Approach to Human ABO Histo-Blood Group Type 2 Antigens

Molecules, 2013
A new chemical approach to synthesizing human ABO histo-blood type 2 antigenic determinants was developed. N-Phthaloyl-protected lactosaminyl thioglycoside derived from lactulose via the Heyns rearrangement was employed to obtain a type 2 core ...
Atsushi Hara, Akihiro Imamura, Hiromune Ando, Hideharu Ishida, Makoto Kiso   +4 more
doaj   +1 more source

Epidemiology of enteric virus infections in children living in the Amazon region

International Journal of Infectious Diseases, 2021
Objectives: To verify the frequency of viruses causing acute gastroenteritis (AGE) in association with the histo-blood group antigen (HBGA) and Rotarix™ vaccination coverage in children from the Amazon region.
Alberto Ignacio Olivares Olivares, Gabriel Azevedo Alves Leitão, Yan Cardoso Pimenta, Carina Pacheco Cantelli, Tulio Machado Fumian, Alexandre Madi Fialho, Sergio da Silva e Mouta, Junior, Isabella Fernandes Delgado, Johan Nordgren, Lennart Svensson, Marize Pereira Miagostovich, José Paulo Gagliardi Leite, Marcia Terezinha Baroni de Moraes   +12 more
doaj   +1 more source

Norovirus and Histo-Blood Group Antigens

Japanese Journal of Infectious Diseases, 2011
Norovirus (NoV), a member of the family Caliciviridae, is a major cause of acute water- and food-borne nonbacterial gastroenteritis and forms antigenically diverse groups of viruses. Human NoVs are divided into at least three genogroups, genogroups I (GI), GII, and GIV, which contain at least 15, 18, and 1 genotypes, respectively.
openaire   +2 more sources

Association of Histo–Blood Group Antigens and Susceptibility to Norovirus Infections [PDF]

The Journal of Infectious Diseases, 2005
Noroviruses (NoVs) are the leading cause of viral gastroenteritis in humans of all ages. Challenge studies that used the NoV prototype strain Norwalk virus (NV) have shown that some individuals are not susceptible to infection, suggesting the absence of a receptor. Recent studies have identified histo-blood group antigens (HBGAs) as possible receptors.
Barry H G, Rockx, Harry, Vennema, Christian J P A, Hoebe, Erwin, Duizer, Marion P G, Koopmans   +4 more
openaire   +2 more sources

Specific Interactions between Human Norovirus and Environmental Matrices: Effects on the Virus Ecology

Viruses, 2019
Human norovirus is the major cause of non-bacterial epidemic gastroenteritis. Human norovirus binds to environmental solids via specific and non-specific interactions, and several specific receptors for human norovirus have been reported.
Mohan Amarasiri, Daisuke Sano
doaj   +1 more source

Low Levels of Natural Anti-α-N-Acetylgalactosamine (Tn) Antibodies Are Associated With COVID-19

Frontiers in Microbiology, 2021
Human serum contains large amounts of anti-carbohydrate antibodies, some of which may recognize epitopes on viral glycans. Here, we tested the hypothesis that such antibodies may confer protection against COVID-19 so that patients would be preferentially
Adrien Breiman, Adrien Breiman, Nathalie Ruvoën-Clouet, Nathalie Ruvoën-Clouet, Marie Deleers, Marie Deleers, Tiffany Beauvais, Tiffany Beauvais, Nicolas Jouand, Jézabel Rocher, Nicolai Bovin, Nathalie Labarrière, Hanane El Kenz, Hanane El Kenz, Jacques Le Pendu   +14 more
doaj   +1 more source

Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Interactions between glycan‐binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan interactome—the repertoire of glycans recognized and their specificities—is poorly defined.
Duong T. Bui, Elena N. Kitova, Ling Han, Lara K. Mahal, John S. Klassen   +4 more
wiley   +1 more source

A post-translational modification of human Norovirus capsid protein attenuates glycan binding

Nature Communications, 2019
Attachment of human noroviruses to histo blood group antigens (HBGAs) is essential for infection. Here the authors report that an asparagine residue located near the HBGA-attachment site can convert into an iso-aspartate residue through spontaneous ...
Alvaro Mallagaray, Robert Creutznacher, Jasmin Dülfer, Philipp H. O. Mayer, Lena Lisbeth Grimm, Jose Maria Orduña, Esben Trabjerg, Thilo Stehle, Kasper D. Rand, Bärbel S. Blaum, Charlotte Uetrecht, Thomas Peters   +11 more
doaj   +1 more source