Results 31 to 40 of about 211,384 (368)
An ontology for major histocompatibility restriction
Journal of Biomedical Semantics, 2016 MHC molecules are a highly diverse family of proteins that play a key role in cellular immune recognition. Over time, different techniques and terminologies have been developed to identify the specific type(s) of MHC molecule involved in a specific ...
R. Vita +10 more
semanticscholar +1 more source
Advances in Rheumatology, 2021 Background Infections are a major cause of morbidity and mortality in systemic lupus (SLE). Vaccination would be an effective method to reduce infection rate. Coverage for influenza and pneumococcus appears to be low in Latin America.
Edson Hernán Chiganer +2 more
doaj +1 more source
Major histocompatibility complex genomics and human disease.
Annual review of genomics and human genetics (Print), 2013 Over several decades, various forms of genomic analysis of the human major histocompatibility complex (MHC) have been extremely successful in picking up many disease associations.
J. Trowsdale, J. Knight
semanticscholar +1 more source
Population variability in the generation and thymic selection of T-cell repertoires [PDF]
PLoS Computational Biology 16(12) e1008394 (2020), 2020 The diversity of T-cell receptor (TCR) repertoires is achieved by a combination of two intrinsically stochastic steps: random receptor generation by VDJ recombination, and selection based on the recognition of random self-peptides presented on the major histocompatibility complex.
arxiv +1 more source
Marine Drugs, 2017 Sponges, despite their simple body plan, discriminate between self and nonself with remarkable specificity. Sponge grafting experiments simulate the effects of natural self or nonself contact under laboratory conditions.
Laura F. Grice, Bernard M. Degnan
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 1996 Conventional major histocompatibility complex (MHC) class I genes encode molecules that present intracellular peptide antigens to T cells. They are ubiquitously expressed and regulated by interferon gamma.
V. Groh +5 more
semanticscholar +1 more source
False Positive B-Cells Crossmatch after Prior Rituximab Exposure of the Kidney Donor
Case Reports in Transplantation, 2016 Crossmatching is essential prior to kidney transplantation to confirm compatibility between the donor and the recipient, particularly to prevent acute antibody-mediated rejection.
Judith Desoutter +3 more
doaj +1 more source
PCR-based isolation of multigene families: Lessons from the avian MHC class IIB [PDF]
, 2013 The amount of sequence data available today highly facilitates the access to genes from many gene families. Universal primers amplifying the desired genes over a range of species are readily obtained by aligning conserved gene regions, and laborious gene isolation procedures can often be replaced by quicker PCR-based approaches.
arxiv +1 more source
From secretome analysis to immunology: chitosan induces major alterations in the activation of dendritic cells via a TLR4-dependent mechanism [PDF]
Mol Cell Proteomics 8, 6 (2009) 1252-64, 2009 Dendritic cells are known to be activated by a wide range of microbial products, leading to cytokine production and increased levels of membrane markers such as major histocompatibility complex class II molecules. Such activated dendritic cells possess the capacity to activate na\"ive T cells.
arxiv +1 more source
The dual nature of TDC – bridging dendritic and T cells in immunity
FEBS Letters, EarlyView.TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley +1 more source