Results 61 to 70 of about 211,384 (368)

IMGT/HLA and IMGT/MHC: sequence databases for the study of the major histocompatibility complex

Nucleic Acids Res., 2003
The IMGT/HLA database (http://www.ebi.ac.uk/imgt/hla) has provided a centralized repository for the sequences of the alleles named by the WHO Nomenclature Committee for Factors of the HLA System for the past four years.
J. Robinson, M. Waller, P. Parham, N. D. Groot, R. Bontrop, L. Kennedy, P. Stoehr, S. Marsh   +7 more
semanticscholar   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

Haplotype-Based Analysis of KIR-Gene Profiles in a South European Population—Distribution of Standard and Variant Haplotypes, and Identification of Novel Recombinant Structures

Frontiers in Immunology, 2020
Inhibitory Killer-cell Immunoglobulin-like Receptors (KIR) specific for HLA class I molecules enable human natural killer cells to monitor altered antigen presentation in pathogen-infected and tumor cells.
Elisa Cisneros, Manuela Moraru, Natalia Gómez-Lozano, Aura Muntasell, Miguel López-Botet, Miguel López-Botet, Carlos Vilches   +6 more
doaj   +1 more source

Histocompatibility

AbstractHuman leukocyte antigen (HLA) molecules are the most important histocompatibility antigens, due to their genetic polymorphism and their key role in peptide antigen presentation and T-cell alloreactivity. While full matching for the most relevant HLA loci had been regarded as a prerequisite for successful transplantation until recently, the ...
Spierings, Eric, Madrigal, Alejandro, Fleischhauer, Katharina   +2 more
openaire   +2 more sources

Impact of donor-specific anti-HLA antibodies on graft failure and survival after reduced intensity conditioning-unrelated cord blood transplantation: a Eurocord, Société Francophone d’Histocompatibilité et d’Immunogénétique (SFHI) and Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC) analysis

Haematologica, 2013
Graft failure is a major complication after unrelated cord blood transplantation. Presence of HLA-antibodies before cord blood transplantation may impact graft failure.
Annalisa Ruggeri, Vanderson Rocha, Emeline Masson, Myriam Labopin, Renato Cunha, Lena Absi, Ali Boudifa, Brigitte Coeffic, Anne Devys, Muriel De Matteis, Valérie Dubois, Daniel Hanau, Françoise Hau, Isabelle Jollet, Dominique Masson, Beatrice Pedron, Pascale Perrier, Christophe Picard, Annie Ramouneau-Pigot, Fernanda Volt, Dominique Charron, Eliane Gluckman, Pascale Loiseau   +22 more
doaj   +1 more source

The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype

Journal of Experimental Medicine, 1984
We have prepared a monoclonal antibody, KJ16-133, from the cells of a rat immunized with the purified receptor for antigen plus I-A of a BALB/c T cell hybridoma, DO-11.10.
Kathryn Haskins, Charles H Hannum, Janicé White, N. Roehm, Ralph T. Kubo, J. Kappler, P. Marrack   +6 more
semanticscholar   +1 more source

CSF cytokine, chemokine and injury biomarker profile of glial fibrillary acidic protein (GFAP) autoimmunity

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Defining the CSF cytokine/chemokine and injury biomarker signature of glial fibrillary acidic protein (GFAP) autoimmunity can inform immunopathogenesis. CSF GFAP‐IgG‐positive samples (N = 98) were tested for 17 cytokines/chemokines, neurofilament light chain (NfL), and GFAP (ELLA, Bio‐Techne).
Yahel Segal, Georgios Mangioris, Vanda Lennon, Binxia Yang, Divyanshu Dubey, Eoin P. Flanagan, Andrew McKeon, John R. Mills, Michel Toledano, Ivana Vodopivec, Sean J. Pittock, Anastasia Zekeridou   +11 more
wiley   +1 more source

Protective association of VDR gene polymorphisms and haplotypes with multiple sclerosis patients in Egyptian population

Egyptian Journal of Medical Human Genetics, 2019
Background Hypovitaminosis D is one of the hazardous factors for multiple sclerosis (MS) and can be attested by expanding clinical studies. We aimed to study vitamin D receptor (VDR) gene polymorphisms: FokI, BsmI, ApaI, TaqI, and Tru9I genotype ...
Amina H. Hassab, Ahmed H. Deif, Dalia A. Elneely, Ireny M. Tawadros, Amira I. Fayad   +4 more
doaj   +1 more source

Solutions to Avoid False Positives for Rituximab in Pre-Transplant Crossmatches

Antibodies, 2020
Rituximab (anti-CD20) is commonly used as immunotherapy against B cells, in the context of pre-transplant crossmatches, where the presence of rituximab in the tested sera with donor cells can alter their results both by flow cytometry (FCXM) as ...
Argentina Colmenero Velazquez, Ignacio Iturrieta-Zuazo, Juan Luis Valdivieso Shephard, Marisa Di Natale, Claudia Rita, Rubén Ballester González, José Luis Castañer Alabau, Israel Nieto Gañán   +7 more
doaj   +1 more source

Expression of MHC II genes [PDF]

Current topics in microbiology and immunology. 290 (2005) Pages 147-70, Accession Number 16480042, 2006
Innate and adaptive immunity are connected via antigen processing and presentation (APP), which results in the presentation of antigenic peptides to T cells in the complex with the major histocompatibility (MHC) determinants. MHC class II (MHC II) determinants present antigens to CD4+ T cells, which are the main regulators of the immune response. Their
arxiv