Results 61 to 70 of about 19,757 (171)
Association of TLR4-T399I Polymorphism with Chronic Obstructive Pulmonary Disease in Smokers
Clinical and Developmental Immunology, 2009 Tobacco smoking has been considered the most important risk factor for chronic obstructive pulmonary disease (COPD) development. However, not all smokers develop COPD and other environmental and genetic susceptibility factors underlie disease ...
Matthaios Speletas +6 more
doaj +1 more source
The Robust Kernel Association Test [PDF]
arXiv, 2019 Testing the association between SNP effects and a response is a common task. Such tests are often carried out through kernel machine methods based on least squares, such as the Sequence Kernel Association Test (SKAT). However, these least squares procedures assume a normally distributed response, which is often violated. Other robust procedures such as
arxiv
Persistent Activation of Innate Immunity in Patients with Primary Antibody Deficiencies
Journal of Immunology Research, 2020 Primary antibody deficiencies (PAD) represent a heterogeneous group of disorders, with common variable immunodeficiency being the most common with clinical significance. The main phenotypic defect resides in the inability of B cells to produce antibodies,
Gerasimina Tsinti +3 more
doaj +1 more source
Ranking-based Convolutional Neural Network Models for Peptide-MHC Binding Prediction [PDF]
arXiv, 2020 T-cell receptors can recognize foreign peptides bound to major histocompatibility complex (MHC) class-I proteins, and thus trigger the adaptive immune response. Therefore, identifying peptides that can bind to MHC class-I molecules plays a vital role in the design of peptide vaccines. Many computational methods, for example, the state-of-the-art allele-
arxiv
BOOST: A fast approach to detecting gene-gene interactions in genome-wide case-control studies [PDF]
arXiv, 2010 Gene-gene interactions have long been recognized to be fundamentally important to understand genetic causes of complex disease traits. At present, identifying gene-gene interactions from genome-wide case-control studies is computationally and methodologically challenging.
arxiv
Histocompatibility and Tumor Virus Antigens Identified on Cells Grown in Tissue Culture by Means of the Mixed Hemadsorption Reaction [PDF]
, 1967 Rolf F. Barth +2 more
openalex +1 more source
Frontiers in Immunology, 2018 Killer cell immunoglobulin-like receptors (KIR), considered the most polymorphic natural killer (NK) cell regulators, bind HLA class-I molecules or still unknown ligands.
Laia Closa +7 more
doaj +1 more source
Histocompatibilidad: pasado, presente y futuro
Revista Cubana de Hematología, Inmunología y HemoterapiaLa histocompatibilidad es la rama de la Inmunología que estudia o tipifica los antígenos expresados en la superficie de los leucocitos, de gran polimorfismo, determinados genéticamente por diferentes variantes alélicas, implicados en el rechazo del ...
Consuelo Macías Abraham
doaj
Clinical and Developmental Immunology, 2012 Abnormalities in monocytes and in peripheral blood dendritic cells (DC) subsets have been reported in systemic lupus erythematosus (SLE). We aim to clarify the tolerogenic or inflammatory role of these cells based on ICOSL or IFN-α and chemokine mRNA ...
Tiago Carvalheiro +9 more
doaj +1 more source