Results 61 to 70 of about 150,622 (302)

Distinct Intracellular Compartments Involved in Invariant Chain Degradation and Antigenic Peptide Loading of Major Histocompatibility Complex (MHC) Class II Molecules [PDF]

, 1997
Major histocompatibility complex (MHC) class II molecules are transported to intracellular MHC class II compartments via a transient association with the invariant chain (Ii).
Ferrari, G., Knight, A. M., Watts, C., Pieters, J.   +3 more
core   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

RELATIONSHIP BETWEEN THE REPRESENTATION OF VARIOUS HISTOCOMPATIBILITY ANTIGENS AND THE IDENTIFICATION OF PATHOGENIC AND SAPROPHYTIC STAPHYLOCOCCUS STRAINS AS AN ETIOLOGICAL SUBSTRATE OF SECONDARY PYELONEPHRITIS IN CHILDREN WITH CONGENITAL OBSTRUCTIVE UROPATHIES

Медицинская иммунология, 2019
The study involved 73 patients aged 5-15 years of Russian nationality admitted to a surgical hospital for surgical treatment of congenital obstructive uropathies (hydronephrosis, vesicoureteral reflux, megaureter).
V. S. Borovitsky, M. P. Razin
doaj   +1 more source

Clonal variation in cell surface display of an H-2 protein lacking a cytoplasmic tail [PDF]

, 1986
Truncated variants of the gene encoding H-2Ld, an integral membrane protein encoded by the major histocompatibility complex, were constructed by in vitro mutagenesis to elucidate the function of charged amino acids found on the cytoplasmic side of the ...
Hood, Leroy E., Zuñiga, Martha C.
core  

Transdermal Delivery of an mRNA‐Liposome Vaccine via Dissolving Microneedle to Preserve Vaccine Activity and Enhance Immune Activation

Advanced Science, EarlyView.
An mRNA‐liposome vaccine via dissolving microneedles (ML‐DMN) enables efficient skin‐targeted delivery while preserving mRNA integrity and allowing sustained antigen expression. Unlike intramuscular (IM) injection, ML‐DMN engages skin‐resident immune cells, activates antigen‐presenting cells (APCs), and induces strong T cell and cytokine responses at ...
Jeehye Nam, JiWon Ahn, Jiwoo Shin, Nahong Lee, Youjin Lee, Sung min Cho, Paul Kim, Geonwoo Kang, Sang‐Jun Ha, Hyungil Jung   +9 more
wiley   +1 more source

Genetic diversity among volunteer donors of bone marrow in southeastern Brazil, according to the HLA system

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Checking the histocompatibility of the molecules of the human leukocyte antigen (HLA) system is vital for performing bone marrow transplantation with allogeneic material.
Letícia Sarni Roque, Rodolpho Telarolli-Junior, Leonor Castro Monteiro Loffredo   +2 more
doaj   +1 more source

The Association of Myasthenia Gravis with HLA class II Antigens in Iraqi Patients

مجلة بغداد للعلوم, 2013
The nature and intensity of the association of myasthenia gravis (MG) with distinct human leukocyte antigen (HLA) haplotypes differ between ethnic populations, so this study determined the association of HLA class II antigens with myasthenia gravis (MG ...
Baghdad Science Journal
doaj   +1 more source

Diversity of HLA Class I and Class II blocks and conserved extended haplotypes in Lacandon Mayans. [PDF]

, 2020
Here we studied HLA blocks and haplotypes in a group of 218 Lacandon Maya Native American using a high-resolution next generation sequencing (NGS) method.
Aguilar-Vázquez, José Artemio, Barquera, Rodrigo, Barsakis, Konstantinos, Corona, Teresa, Cruz-Lagunas, Alfredo, Fernández-Viña, Marcelo, Flores-Rivera, José, García-Lechuga, Maricela, Granados, Julio, Hernández-Zaragoza, Diana Iraíz, Jiménez-Alvarez, Luis, Jonapá-Gómez, Letisia, Mallempati, Kalyan C, Mena-Hernández, Lourdes, Mindrinos, Michael, Ochoa-Morales, Adriana, Ortega, Esteban, Penman, Bridget S., Soler, Manuel, Tovar-Méndez, Víctor Hugo, Yescas, Petra, Yunis, Edmond, Yunis, María, Zuniga, Joaquin   +23 more
core   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Nano‐Enabled Systemic Delivery of STING Agonist by Engineered Silicasome for Potent Antitumor Immunotherapy

Advanced Science, EarlyView.
Engineered mesoporous silica nanoparticles (Silicasomes) enable systemic delivery of the STING agonist ADU‐S100, overcoming the instability and toxicity that limit cyclic dinucleotides to local administration. By enhancing tumor accumulation, activating systemic antitumor immunity, and remodeling the tumor immune microenvironment, these nanoparticles ...
Wenjing Zhou, Yuting Li, Xudong Sun, Honghong Yang, Xiayu Shi, Lijia Yao, Jinhong Jiang, Erli Wang, Haoyang Wang, Yi Wei, Xiangsheng Liu   +10 more
wiley   +1 more source