Results 71 to 80 of about 149,353 (305)

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

The Association of Myasthenia Gravis with HLA class II Antigens in Iraqi Patients

مجلة بغداد للعلوم, 2013
The nature and intensity of the association of myasthenia gravis (MG) with distinct human leukocyte antigen (HLA) haplotypes differ between ethnic populations, so this study determined the association of HLA class II antigens with myasthenia gravis (MG ...
Baghdad Science Journal
doaj   +1 more source

Histocompatibility antigens and geographic tongue

Oral Surgery, Oral Medicine, Oral Pathology, 1993
The HLA-A, B and HLA-DR antigens were investigated in 50 unrelated Greek persons with geographic tongue and in 380 healthy control persons. An increased incidence of DR5 and DRW6 antigens was observed in the blood of persons with geographic tongue. Ten (20%) of them had the DRW6 antigen, and it was significantly increased compared with 29 (7.6%) of the
FENERLI, A, PAPANICOLAOU, S, PAPANICOLAOU, M, LASKARIS, G   +3 more
openaire   +3 more sources

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Genetic diversity among volunteer donors of bone marrow in southeastern Brazil, according to the HLA system

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Checking the histocompatibility of the molecules of the human leukocyte antigen (HLA) system is vital for performing bone marrow transplantation with allogeneic material.
Letícia Sarni Roque, Rodolpho Telarolli-Junior, Leonor Castro Monteiro Loffredo   +2 more
doaj   +1 more source

Minors come of age: minor histocompatibility antigens and graft-versus-host disease [PDF]

, 2004
Minor histocompatibility antigens (miHA) are responsible for the occurrence of graft-versus-host disease in the setting of a major histocompatibility complex matched sibling allogeneic stem cell transplantation.
Chao, Nelson J
core   +1 more source

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

RELATIONSHIP BETWEEN THE REPRESENTATION OF VARIOUS HISTOCOMPATIBILITY ANTIGENS AND THE IDENTIFICATION OF PATHOGENIC AND SAPROPHYTIC STAPHYLOCOCCUS STRAINS AS AN ETIOLOGICAL SUBSTRATE OF SECONDARY PYELONEPHRITIS IN CHILDREN WITH CONGENITAL OBSTRUCTIVE UROPATHIES

Медицинская иммунология, 2019
The study involved 73 patients aged 5-15 years of Russian nationality admitted to a surgical hospital for surgical treatment of congenital obstructive uropathies (hydronephrosis, vesicoureteral reflux, megaureter).
V. S. Borovitsky, M. P. Razin
doaj   +1 more source

Polymorphism of the tumor necrosis factor beta gene in systemic lupus erythematosus [PDF]

, 1993
We investigated the Nco I restriction fragment length polymorphism (RFLP) of the tumor necrosis factor beta (TNFB) gene in 173 patients with systemic lupus erythematosus (SLE), 192 unrelated healthy controls, and eleven panel families, all of German ...
Albert, E. D., Bettinotti, M. P., Deicher, H., Hartung, K., Keller, E., Messer, Gerald, Weiss, Elisabeth H.   +6 more
core   +1 more source

Diversity of HLA Class I and Class II blocks and conserved extended haplotypes in Lacandon Mayans. [PDF]

, 2020
Here we studied HLA blocks and haplotypes in a group of 218 Lacandon Maya Native American using a high-resolution next generation sequencing (NGS) method.
Aguilar-Vázquez, José Artemio, Barquera, Rodrigo, Barsakis, Konstantinos, Corona, Teresa, Cruz-Lagunas, Alfredo, Fernández-Viña, Marcelo, Flores-Rivera, José, García-Lechuga, Maricela, Granados, Julio, Hernández-Zaragoza, Diana Iraíz, Jiménez-Alvarez, Luis, Jonapá-Gómez, Letisia, Mallempati, Kalyan C, Mena-Hernández, Lourdes, Mindrinos, Michael, Ochoa-Morales, Adriana, Ortega, Esteban, Penman, Bridget S., Soler, Manuel, Tovar-Méndez, Víctor Hugo, Yescas, Petra, Yunis, Edmond, Yunis, María, Zuniga, Joaquin   +23 more
core   +1 more source