Results 71 to 80 of about 92,035 (255)

Strategies for inducing diabetes in laboratory animals: Advances from chemical, surgical, immunologic, dietary, and genetic approaches

Animal Models and Experimental Medicine, EarlyView.
This review summarizes the principal experimental approaches used to induce diabetes in animal models. Strategies include chemical agents (streptozotocin, alloxan, dithizone, gold thioglucose), dietary interventions (high‐fat and high‐sugar diets), surgical methods (total or partial pancreatectomy), genetic models (db/db, ob/ob, Goto‐Kakizaki [GK ...
Milad Faraji, Maedeh Faraji, Nasrin Kazemipour   +2 more
wiley   +1 more source

Associations of minor histocompatibility antigens with outcomes following allogeneic hematopoietic cell transplantation. [PDF]

Am J Hematol, 2023
Jadi O, Tang H, Olsen K, Vensko S, Zhu Q, Wang Y, Haiman CA, Pooler L, Sheng X, Brock G, Webb A, Pasquini MC, McCarthy PL, Spellman SR, Hahn T, Vincent B, Armistead P, Sucheston-Campbell LE.   +17 more
europepmc   +1 more source

Proinflammatory Epstein–Barr Virus Antibody Functions Track with Disease Activity in Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Epstein–Barr virus (EBV) has been implicated in the pathogenesis of multiple sclerosis (MS). Elevated immunoglobulin G (IgG) titers against EBV nuclear antigen 1 (EBNA1) represent the most consistent serological marker of MS risk, with levels remaining persistently elevated following disease onset.
Malina Behrens, Paula Terroba‐Navajas, Eline A.J. Willemse, Sabine Schädelin, Manuel Comabella, Christian Münz, Gordan Lauc, Yannic Bartsch, Jens Kuhle, Jan D. Lünemann   +9 more
wiley   +1 more source

Two Years of Ocrelizumab Treatment in Black and Hispanic People with Multiple Sclerosis in CHIMES: A Single‐Arm Clinical Trial

Annals of Neurology, EarlyView.
Objective To evaluate the effectiveness and safety of ocrelizumab in self‐identified black and Hispanic people with relapsing multiple sclerosis. Methods The Characterization of Ocrelizumab in Minorities with Multiple Sclerosis (CHIMES) trial, a prospective, open‐label, single‐arm, phase 4 study, intentionally recruited underrepresented populations in ...
Lilyana Amezcua, Anthony T. Reder, Evanthia Bernitsas, Nancy L. Monson, Timothy Vartanian, Gregory F. Wu, Mansoor Saleh, Annette Okai, Ahmed Z. Obeidat, Dilraj Sokhi, Rikisha Parekh, Jinglan Pei, Christopher Harp, David Clayton, Ibraheem Abioye, Mitzi J. Williams, for the CHIMES Study Group   +16 more
wiley   +1 more source

Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations.

PLoS Genetics, 2007
Minor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen-matched solid organ and stem cell transplantation (SCT).
Eric Spierings, Matthijs Hendriks, Léna Absi, Angelica Canossi, Sonal Chhaya, John Crowley, Harry Dolstra, Jean-François Eliaou, Tom Ellis, Jürgen Enczmann, Maria E Fasano, Thibaut Gervais, Clara Gorodezky, Brigitte Kircher, David Laurin, Mary S Leffell, Pascale Loiseau, Mari Malkki, Miroslaw Markiewicz, Miryam Martinetti, Etsuko Maruya, Narinder Mehra, Fatma Oguz, Machteld Oudshoorn, Noemi Pereira, Rajni Rani, Ruhena Sergeant, Jackie Thomson, Thuong Hien Tran, Hannu Turpeinen, Kuo-Liang Yang, Renata Zunec, Mary Carrington, Peter de Knijff, Els Goulmy   +34 more
doaj   +1 more source

Antibody Responses to Minor Histocompatibility Antigens After Solid Organ Transplantation. [PDF]

Transplantation, 2022
Zorn E, See SB.
europepmc   +1 more source

Rewriting Tumor Immunity With Bacterial Membrane Vesicles: A Versatile and Potent Therapeutic Strategy

Advanced NanoBiomed Research, EarlyView.
Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi, Md Mijanur Rahman, Asma Talukder, Urooj Yousaf Virk, Jennifer C. Wilson, Nigel McMillan, Ming Q. Wei   +6 more
wiley   +1 more source

Investigation of the protective efficacy of Caesalpinia sappan and spirulina against ethanol-induced experimental rat gastritis model

Acta Cirúrgica Brasileira
Purpose: To evaluate the protective effect of Caesalpinia sappan and spirulina against gastritis and determine changes in the expression of CD8, CD68, and major histocompatibility complex (MHC) molecules.
İdris Oruç, Zelal Karakoç, Filiz Akduman, Zeynep Oruç, Nazan Baksi, Muzaffer Aydin Ketani   +5 more
doaj   +1 more source

Immune Responses to Tissue-Restricted Nonmajor Histocompatibility Complex Antigens in Allograft Rejection

Journal of Immunology Research, 2017
Chronic diseases that result in end-stage organ damage cause inflammation, which can reveal sequestered self-antigens (SAgs) in that organ and trigger autoimmunity. The thymus gland deletes self-reactive T-cells against ubiquitously expressed SAgs, while
Ankit Bharat, T. Mohanakumar
doaj   +1 more source

ROLE OF HLA IN RENAL TRANSPLANT REJECTION

Alʹmanah Kliničeskoj Mediciny, 2016
It is known that the number of matches of the major histocompatibility complex antigens has a direct relationship with the duration of a renal transplant functioning.
A. V. Vatazin, A. B. Zulkarnayev, N. G. Dmitrieva, O. N. Jakovchik, V. A. Fedulkina   +4 more
doaj   +1 more source