Results 271 to 280 of about 68,749 (310)

Structure of the human class I histocompatibility antigen, HLA-A2

Nature, 1987
The class I histocompatibility antigen from human cell membranes has two structural motifs: the membrane-proximal end of the glycoprotein contains two domains with immunoglobulin-folds that are paired in a novel manner, and the region distal from the membrane is a platform of eight antiparallel beta-strands topped by alpha-helices.
P J, Bjorkman, M A, Saper, B, Samraoui, W S, Bennett, J L, Strominger, D C, Wiley   +5 more
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Structure of Class I Major Histocompatibility Antigens

1983
H-2 antigens were discovered by Gorer (1936) as a blood group system associated with histocompatibility between mouse strains. Later research indicated that H-2 antigens were encoded by a series of genes, hence the designation H-2 complex (J. Klein, 1975).
E S, Kimball, J E, Coligan
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ANTIGEN PROCESSING AND PRESENTATION BY THE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX

Annual Review of Immunology, 1996
▪ Abstract  Major histocompatibility complex (MHC) class I molecules bind peptides derived from cellular proteins and display them for surveillance by the immune system. These peptide-binding molecules are composed of a heavy chain, containing an antigen-binding groove, which is tightly associated with a light chain (β2-microglobulin).
I A, York, K L, Rock
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Generation of major histocompatibility complex class I antigens

Microbes and Infection, 2003
Presentation of antigenic peptides by major histocompatibility complex (MHC) class I molecules on the surface of antigen-presenting cells is an effective extracellular representation of the intracellular antigen content. The intracellular proteasome-dependent proteolytic machinery is required for generating MHC class I-presented peptides.
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Presentation of Exogenous Antigen with Class I Major Histocompatibility Complex Molecules

Science, 1990
Soluble antigens (Ags) in the extracellular fluids are excluded from the class I major histocompatibility complex (MHC)-restricted pathway of Ag presentation in most cells. However, an exogenous Ag can be internalized, processed, and presented in association with class I MHC molecules on specialized Ag-presenting cells (APCs).
K L, Rock, S, Gamble, L, Rothstein
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The rat placenta expresses paternal class I major histocompatibility antigens

Journal of Reproductive Immunology, 1986
The expression of paternally inherited class I MHC antigens on the placental trophoblast of the rat has been investigated using a mouse anti-rat monoclonal antibody (MN4-91-6) in an indirect immunoperoxidase labelling assay on cryostat sections. Strong specific staining was obtained on the spongy zone trophoblast of the mature placenta from DA male ...
W D, Billington, F J, Burrows
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Antigen Presentation by Major Histocompatibility Complex Class I-B Molecules

Annual Review of Immunology, 1994
Class I-b genes constitute the majority of MHC class I loci. These monomorphic or oligomorphic molecules have been described in many organisms; they are best characterized in the mouse, which contains a substantial number of potentially intact genes.
S M, Shawar, J M, Vyas, J R, Rodgers, R R, Rich   +3 more
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Effect of Temperature on the Expression of Major Histocompatibility Complex Class-I Antigens

Immunological Investigations, 1992
In the present study we investigated the effect of temperature on MHC class-I gene expression in BALB/C 3T3 cells incubated for 5 days at 34 degrees C, 37 degrees C and 39 degrees C. FACS analysis revealed no significant difference in the cell surface expression of any of the 3 major class-I antigens at 34 degrees C and 37 degrees C.
M, Aboud, S, Segal, E, Priel, D G, Blair, B, O'Hara   +4 more
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Presentation of an exogenous antigen by major histocompatibility complex class I molecules

European Journal of Immunology, 1994
AbstractCytotoxic T lymphocytes (CTL) generally recognize peptides derived from endogenously expressed proteins in association with nascent major histocompatibility complex (MHC) class I molecules. In contrast, peptides derived from exogenous proteins associate with MHC class II following endocytosis to an endosomal compartment.
J B, Ulmer, J J, Donnelly, M A, Liu
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ALLOSPECIFIC MONOCLONAL ANTIBODIES RECOGNIZING RAT CLASS I AND CLASS II HISTOCOMPATIBILITY ANTIGENS

Transplantation, 1982
Rat-mouse hybridomas have been developed producing monoclonal antibodies which recognize rat major histocompatibility complex specificities. Splenic lymphocytes from a LEW (RT1l) rat alloimmunized against ACI (Rt1a) splenocytes were used for hybridoma production.
E E, Engel, R D, Guttmann, A, Fuks
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