Results 291 to 300 of about 23,603,276 (341)
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Structure of Class I Major Histocompatibility Antigens
Contemporary topics in molecular immunology, 1983H-2 antigens were discovered by Gorer (1936) as a blood group system associated with histocompatibility between mouse strains. Later research indicated that H-2 antigens were encoded by a series of genes, hence the designation H-2 complex (J. Klein, 1975).
E S, Kimball, J E, Coligan
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Journal of Oral Pathology & Medicine, 1987
The expression of the Class I and Class II major histocompatibility antigens on oral mucosa was investigated using type‐specific monoclonal antibodies. Class I antigen expression varied between various sites and in uncomplicated inflammatory responses appeared to be suppressed.
Savage, NW, Walsh, LJ, Seymour, GJ
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The expression of the Class I and Class II major histocompatibility antigens on oral mucosa was investigated using type‐specific monoclonal antibodies. Class I antigen expression varied between various sites and in uncomplicated inflammatory responses appeared to be suppressed.
Savage, NW, Walsh, LJ, Seymour, GJ
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Major histocompatibility antigens: The human (HLA-A,-B,-C) and murine (H-2K, H-2D) class I molecules
Cell, 1981Harry Orr +2 more
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Subunit interactions of class I histocompatibility antigens
Biochemistry, 1985The kinetics of dissociation of iodinated beta 2-microglobulin (beta 2m) from the papain-solubilized class I histocompatibility antigen HLA-B7 have been investigated. In the presence of unlabeled beta 2m, most of the HLA dissociates according to a single rate constant, whereas in the absence of unlabeled beta 2m, the system approaches an equilibrium ...
K C, Parker, J L, Strominger
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Journal of Immunology, 2005
Most of the polymorphic amino acids of the class I histocompatibility antigen, HLA-A2, are clustered on top of the molecule in a large groove identified as the recognition site for processed foreign antigens. Many residues critical for T-cell recognition
P. J. Bjorkman +5 more
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Most of the polymorphic amino acids of the class I histocompatibility antigen, HLA-A2, are clustered on top of the molecule in a large groove identified as the recognition site for processed foreign antigens. Many residues critical for T-cell recognition
P. J. Bjorkman +5 more
semanticscholar +1 more source
Proteolysis and class I major histocompatibility complex antigen presentation
Immunological Reviews, 1999Summary: The class I major histocompatibility complex (MHC class 1) presents 8–10 residue peptides to cytotoxic T lymphocytes. Most of these antigenic peptides are generated during protein degradation in the cytoplasm and are then transported into the endoplasmic reticulum by the transporter associated with antigen processing (TAP), Several lines of ...
I A, York +3 more
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ANTIGEN PROCESSING AND PRESENTATION BY THE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX
Annual Review of Immunology, 1996▪ Abstract Major histocompatibility complex (MHC) class I molecules bind peptides derived from cellular proteins and display them for surveillance by the immune system. These peptide-binding molecules are composed of a heavy chain, containing an antigen-binding groove, which is tightly associated with a light chain (β2-microglobulin).
I A, York, K L, Rock
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Generation of major histocompatibility complex class I antigens
Microbes and Infection, 2003Presentation of antigenic peptides by major histocompatibility complex (MHC) class I molecules on the surface of antigen-presenting cells is an effective extracellular representation of the intracellular antigen content. The intracellular proteasome-dependent proteolytic machinery is required for generating MHC class I-presented peptides.
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Construction of novel class I histocompatibility antigens by interspecies exon shuffling.
Journal of Immunology, 1985Human and mouse class I histocompatibility antigens share considerable structural homology at both the protein and DNA sequence level. This homology has allowed the production of hybrid class I molecules by the reciprocal exchange of DNA sequences ...
V. Engelhard +4 more
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The rat placenta expresses paternal class I major histocompatibility antigens
Journal of Reproductive Immunology, 1986The expression of paternally inherited class I MHC antigens on the placental trophoblast of the rat has been investigated using a mouse anti-rat monoclonal antibody (MN4-91-6) in an indirect immunoperoxidase labelling assay on cryostat sections. Strong specific staining was obtained on the spongy zone trophoblast of the mature placenta from DA male ...
W D, Billington, F J, Burrows
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