Results 271 to 280 of about 60,221 (291)
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Unaltered class II histocompatibility antigens and pathogenesis of IDDM in BB rats
Diabetes, 1989The BB rat spontaneously develops insulin-dependent diabetes mellitus (IDDM) as an autoimmune abnormality involving the class II molecules of the major histocompatibility complex (MHC). The rat MHC (RT1 complex) encodes two class II loci, RT1 .B and RT1.D.
E W, Holowachuk, M K, Greer
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Expression of Major Histocompatibility Complex Class II Antigens in Porcine Leptospiral Nephritis
Veterinary Pathology, 2009Class II major histocompatibility complex (MHCII) is required for the presentation of antigens to CD4 helper T cells. During nephritis, not only primary antigen presenting cells such as histiocytes and lymphocytes, but also cytokine-stimulated tubular epithelial cells express MHCII.
E. Radaelli +8 more
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Peptide binding and antigen presentation by class II histocompatibility glycoproteins
Biopolymers, 1997The immune system has evolved complex mechanisms for the recognition and elimination of pathogens. CD4+ helper T lymphocytes play a central role in orchestrating immune responses and their activation is carefully regulated. These cells selectively recognize short peptide antigens stably associated with membrane-bound class II histocompatibility ...
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Biosynthesis and processing of class II histocompatibility antigens.
Critical reviews in immunology, 1987The class II major histocompatibility antigens at the cell surface exist as heterodimers of alpha and beta subunits. During biosynthesis, these subunits are associated with a third chain, the invariant (I) or I chain. Association with the I chain occurs early in biosynthesis in the rough endoplasmic reticulum and persists during transport through the ...
P, Cresswell +3 more
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Class II histocompatibility antigens on human dendritic cells.
Immunology, 1987Histocompatibility antigens of the HLA D locus on the surface of human dendritic cells (DC) were visualized in the electron microscope using immunogold labelling. DC from peripheral blood expressed DR that was frequently concentrated at junctions between aggregating DC and lymphocytes or DC and macrophages.
S C, Knight +3 more
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First-trimester human trophoblast is class II major histocompatibility complex mRNA+/antigen−
Human Immunology, 1994Lack of expression of the polymorphic class I and class II MHC antigens in the cytotrophoblast is one of the major factors determining the privileged immunologic status of the placenta. In this report, we show that first-trimester human placental cytotrophoblast cells display moderate to strong expression of class II MHC (HLA-DR alpha and -DR beta) and
P, Giacomini +9 more
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Differential expression of major histocompatibility complex class II antigens on human keratinocytes
Journal of the American Academy of Dermatology, 1988Skin biopsies from 136 patients with 30 different dermatoses and eight biopsies of normal skin were investigated with the avidin-biotin-peroxidase complex method with regard to the expression of major histocompatibility complex class II antigens human leukocyte antigen (HLA) HLA-DR, HLA-DQ, HLA-DP on keratinocytes.
H, Niedecken +3 more
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Methods in enzymology, 2009
Major histocompatibility complex (MHC) class I and II molecules can both present cytosolic and nuclear antigens to CD8(+) and CD4(+) T cells, respectively. However, MHC class I displays proteasomal, whereas MHC class II molecules display lysosomal, degradation products. One pathway by which intracellular antigens gain access to lysosomal degradation is
Gannagé, M, Münz, C
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Major histocompatibility complex (MHC) class I and II molecules can both present cytosolic and nuclear antigens to CD8(+) and CD4(+) T cells, respectively. However, MHC class I displays proteasomal, whereas MHC class II molecules display lysosomal, degradation products. One pathway by which intracellular antigens gain access to lysosomal degradation is
Gannagé, M, Münz, C
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Keratinocyte class II histocompatibility antigen expression
British Journal of Dermatology, 1985B J, Nickoloff +3 more
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Class II Antigens of the Human Major Histocompatibility Complex
1987Progress in the biological sciences has been remarkable during the past several decades. As the level of sophisticated knowledge expands it becomes difficult if not impossible for the individual investigator to master but a tiny segment of current biology.
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