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The major histocompatibility complex of the horse : class II antigens and genes [PDF]
, 2023 Despite the increasing knowledge of the MHC in many animals, little is known about the MHC of the horse. Little is known about the function of the equid immune system with most studies placing emphasis on strictly immunogenetic analysis of the equine MHC.
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Expression of major histocompatibility complex class II antigens in the canine intestine
Veterinary Immunology and Immunopathology, 1998Immunohistochemical techniques were used to assess major histocompatibility complex (MHC) class II expression by enterocytes and lamina propria cells in the canine intestinal tract. Duodenal enterocyte class II expression was faint and limited to the lower crypt region whereas jejunal and ileal enterocyte expression was stronger, being present in both ...
A J, German +3 more
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Class II major histocompatibility antigens and the etiology of systemic lupus erythematosus
Clinical Immunology and Immunopathology, 1983It is hypothesized that the underlying immunoregulatory dysfunction in systemic lupus erythematosus (SLE) is altered recognition by T cells of self class II major histocompatibility antigens (Ia). The resultant cellular autoreactivity would directly cause certain of the immunopathological manifestations of SLE. The perception by T cells of self non-MHC
R A, Eisenberg, P L, Cohen
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Peptide binding and antigen presentation by class II histocompatibility glycoproteins
Biopolymers, 1997The immune system has evolved complex mechanisms for the recognition and elimination of pathogens. CD4+ helper T lymphocytes play a central role in orchestrating immune responses and their activation is carefully regulated. These cells selectively recognize short peptide antigens stably associated with membrane-bound class II histocompatibility ...
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Structure and Polymorphism of Murine and Human Class II Major Histocompatibility Antigens
Immunological Reviews, 1985The molecular analysis of the Class II region of the MHC of mice and of humans has to date led to some important conclusions. These regions encode sizeable families of related loci, at least 2 alpha and 6 beta in mice and 6 alpha and 7 beta in man. In addition to the sizeable number of potential molecules that could be expressed by the loci of this ...
J I, Bell, D W, Denny, H O, McDevitt
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ALLOSPECIFIC MONOCLONAL ANTIBODIES RECOGNIZING RAT CLASS I AND CLASS II HISTOCOMPATIBILITY ANTIGENS
Transplantation, 1982Rat-mouse hybridomas have been developed producing monoclonal antibodies which recognize rat major histocompatibility complex specificities. Splenic lymphocytes from a LEW (RT1l) rat alloimmunized against ACI (Rt1a) splenocytes were used for hybridoma production.
E E, Engel, R D, Guttmann, A, Fuks
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Expression of Major Histocompatibility Complex Class II Antigens in Porcine Leptospiral Nephritis
Veterinary Pathology, 2009Class II major histocompatibility complex (MHCII) is required for the presentation of antigens to CD4 helper T cells. During nephritis, not only primary antigen presenting cells such as histiocytes and lymphocytes, but also cytokine-stimulated tubular epithelial cells express MHCII.
E. Radaelli +8 more
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Biosynthesis and processing of class II histocompatibility antigens.
Critical reviews in immunology, 1987The class II major histocompatibility antigens at the cell surface exist as heterodimers of alpha and beta subunits. During biosynthesis, these subunits are associated with a third chain, the invariant (I) or I chain. Association with the I chain occurs early in biosynthesis in the rough endoplasmic reticulum and persists during transport through the ...
P, Cresswell +3 more
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Major Histocompatibility Complex Class II Antigen Presentation in Hodgkin's Disease
Leukemia & Lymphoma, 1999The malignant cells in Hodgkin's disease (HD), commonly referred to as Hodgkin and Reed-Sternberg (HRS) cells, express major histocompatibility complex (MHC) class II molecules and, like "professional" antigen-presenting cells (APCs), different accessory or costimulatory molecules which can provide an additional activation signal to T cells.
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Processing and Presentation of Antigen by the Class II Histocompatibility System
20101 Introduction 2 The Innate System of Defense, APCs, and Symbiosis with T Cells 3 Antigen Presentation in Thymus and Peripheral Lymphoid Organs 4 MHCII Molecules 5 Stages in Antigen Presentation 6 APC Interactions with T Cells Keywords: innate system of defense, APCs, and T cell symbiosis; antigen presentation in thymus ...
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