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Structural studies of the class II histocompatibility antigens of the ACI rat
Canadian Journal of Biochemistry and Cell Biology, 1985The class II antigens of the ACI rat were studied using both conventional alloantisera and monoclonal antibodies. By sequential immunoprecipitation experiments and cell binding studies, alloantisera were shown to contain antibodies to both the RT1.B and the RT1.D gene products.
A J, Goldner-Sauvé +2 more
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Genetic Complexity and Expression of Human Class II Histocompatibility Antigens
Immunological Reviews, 1985The genes encoding nearly all of the serologically defined class II antigens of the major histocompatibility complex have been isolated. Three class II loci have been studied in great detail. The DR region contains a single alpha gene and 3 beta chain genes, 1 of which is a pseudogene.
A J, Korman +5 more
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Unaltered class II histocompatibility antigens and pathogenesis of IDDM in BB rats
Diabetes, 1989The BB rat spontaneously develops insulin-dependent diabetes mellitus (IDDM) as an autoimmune abnormality involving the class II molecules of the major histocompatibility complex (MHC). The rat MHC (RT1 complex) encodes two class II loci, RT1 .B and RT1.D.
E W, Holowachuk, M K, Greer
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Class II major histocompatibility antigens and the etiology of systemic lupus erythematosus
Clinical Immunology and Immunopathology, 1983It is hypothesized that the underlying immunoregulatory dysfunction in systemic lupus erythematosus (SLE) is altered recognition by T cells of self class II major histocompatibility antigens (Ia). The resultant cellular autoreactivity would directly cause certain of the immunopathological manifestations of SLE. The perception by T cells of self non-MHC
R A, Eisenberg, P L, Cohen
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Expression of major histocompatibility complex class II antigens in the canine intestine
Veterinary Immunology and Immunopathology, 1998Immunohistochemical techniques were used to assess major histocompatibility complex (MHC) class II expression by enterocytes and lamina propria cells in the canine intestinal tract. Duodenal enterocyte class II expression was faint and limited to the lower crypt region whereas jejunal and ileal enterocyte expression was stronger, being present in both ...
A J, German +3 more
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The major histocompatibility complex of the horse : class II antigens and genes [PDF]
, 2023 Despite the increasing knowledge of the MHC in many animals, little is known about the MHC of the horse. Little is known about the function of the equid immune system with most studies placing emphasis on strictly immunogenetic analysis of the equine MHC.
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Structure and Polymorphism of Murine and Human Class II Major Histocompatibility Antigens
Immunological Reviews, 1985The molecular analysis of the Class II region of the MHC of mice and of humans has to date led to some important conclusions. These regions encode sizeable families of related loci, at least 2 alpha and 6 beta in mice and 6 alpha and 7 beta in man. In addition to the sizeable number of potential molecules that could be expressed by the loci of this ...
J I, Bell, D W, Denny, H O, McDevitt
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Peptide binding and antigen presentation by class II histocompatibility glycoproteins
Biopolymers, 1997The immune system has evolved complex mechanisms for the recognition and elimination of pathogens. CD4+ helper T lymphocytes play a central role in orchestrating immune responses and their activation is carefully regulated. These cells selectively recognize short peptide antigens stably associated with membrane-bound class II histocompatibility ...
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ALLOSPECIFIC MONOCLONAL ANTIBODIES RECOGNIZING RAT CLASS I AND CLASS II HISTOCOMPATIBILITY ANTIGENS
Transplantation, 1982Rat-mouse hybridomas have been developed producing monoclonal antibodies which recognize rat major histocompatibility complex specificities. Splenic lymphocytes from a LEW (RT1l) rat alloimmunized against ACI (Rt1a) splenocytes were used for hybridoma production.
E E, Engel, R D, Guttmann, A, Fuks
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Expression of Major Histocompatibility Complex Class II Antigens in Porcine Leptospiral Nephritis
Veterinary Pathology, 2009Class II major histocompatibility complex (MHCII) is required for the presentation of antigens to CD4 helper T cells. During nephritis, not only primary antigen presenting cells such as histiocytes and lymphocytes, but also cytokine-stimulated tubular epithelial cells express MHCII.
E. Radaelli +8 more
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