Results 271 to 280 of about 63,765 (311)
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Biosynthesis and processing of class II histocompatibility antigens.
Critical reviews in immunology, 1987The class II major histocompatibility antigens at the cell surface exist as heterodimers of alpha and beta subunits. During biosynthesis, these subunits are associated with a third chain, the invariant (I) or I chain. Association with the I chain occurs early in biosynthesis in the rough endoplasmic reticulum and persists during transport through the ...
P, Cresswell +3 more
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Major Histocompatibility Complex Class II Antigen Presentation in Hodgkin's Disease
Leukemia & Lymphoma, 1999The malignant cells in Hodgkin's disease (HD), commonly referred to as Hodgkin and Reed-Sternberg (HRS) cells, express major histocompatibility complex (MHC) class II molecules and, like "professional" antigen-presenting cells (APCs), different accessory or costimulatory molecules which can provide an additional activation signal to T cells.
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Class II histocompatibility antigens on human dendritic cells.
Immunology, 1987Histocompatibility antigens of the HLA D locus on the surface of human dendritic cells (DC) were visualized in the electron microscope using immunogold labelling. DC from peripheral blood expressed DR that was frequently concentrated at junctions between aggregating DC and lymphocytes or DC and macrophages.
S C, Knight +3 more
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Journal of Oral Pathology & Medicine, 1987
The expression of the Class I and Class II major histocompatibility antigens on oral mucosa was investigated using type‐specific monoclonal antibodies. Class I antigen expression varied between various sites and in uncomplicated inflammatory responses appeared to be suppressed.
Savage, NW, Walsh, LJ, Seymour, GJ
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The expression of the Class I and Class II major histocompatibility antigens on oral mucosa was investigated using type‐specific monoclonal antibodies. Class I antigen expression varied between various sites and in uncomplicated inflammatory responses appeared to be suppressed.
Savage, NW, Walsh, LJ, Seymour, GJ
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Studies on the Interaction of T Cells with Major Histocompatibility Complex Class II Antigens
Clinical Science, 19951. Major histocompatibility complex class II antigens have the central role in the immune response of ‘presenting’ antigenic peptide to CD4+ T-cells. This interaction with a T-cell's receptor may result in activation, but, if recognition occurs without collateral molecular interactions which cause ‘co-stimulation’, these T-cells will be tolerized.
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European Journal of Immunology, 2003
AbstractBiochemical and functional studies have demonstrated major histocompatibility complex (MHC) class II‐restricted presentation of peptides derived from cytosolic proteins, but the underlying processing and presentation pathways have remained elusive.
Falk, Nimmerjahn +6 more
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AbstractBiochemical and functional studies have demonstrated major histocompatibility complex (MHC) class II‐restricted presentation of peptides derived from cytosolic proteins, but the underlying processing and presentation pathways have remained elusive.
Falk, Nimmerjahn +6 more
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Primary biliary cirrhosis: Associations with class II major histocompatibility complex antigens
Hepatology, 1987Tissue injury in primary biliary cirrhosis is thought to be mediated by immune mechanisms. Various Class II antigens of the major histocompatibility complex are associated with autoimmune diseases and their differing clinical manifestations.
G J, Gores +4 more
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Class II Antigens of the Human Major Histocompatibility Complex
1987Progress in the biological sciences has been remarkable during the past several decades. As the level of sophisticated knowledge expands it becomes difficult if not impossible for the individual investigator to master but a tiny segment of current biology.
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Processing and Presentation of Antigen by the Class II Histocompatibility System
20101 Introduction 2 The Innate System of Defense, APCs, and Symbiosis with T Cells 3 Antigen Presentation in Thymus and Peripheral Lymphoid Organs 4 MHCII Molecules 5 Stages in Antigen Presentation 6 APC Interactions with T Cells Keywords: innate system of defense, APCs, and T cell symbiosis; antigen presentation in thymus ...
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Human retroplacental sera inhibit the expression of class II major histocompatibility antigens
Journal of Reproductive Immunology, 1986Since factor(s) present in human pregnancy sera may interfere with HLA-DR expression on antigen-presenting cells which could account for fetal immune tolerance, we decided to investigate HLA-DR expression on the human myeloid macrophage cell line U937 using the monoclonal antibody RF DR2 and flow cytometry.
N S, Nicholas +3 more
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