Results 361 to 370 of about 453,877 (390)

Expression of Major Histocompatibility Complex Class II Antigens in Porcine Leptospiral Nephritis

Veterinary Pathology, 2009
Class II major histocompatibility complex (MHCII) is required for the presentation of antigens to CD4 helper T cells. During nephritis, not only primary antigen presenting cells such as histiocytes and lymphocytes, but also cytokine-stimulated tubular epithelial cells express MHCII.
E. Radaelli, F. Del Piero, L. Aresu, F. Sciarrone, N. Vicari, S. Mattiello, S. Tagliabue, M. Fabbi, E. Scanziani   +8 more
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Studies on the Interaction of T Cells with Major Histocompatibility Complex Class II Antigens

Clinical Science, 1995
1. Major histocompatibility complex class II antigens have the central role in the immune response of ‘presenting’ antigenic peptide to CD4+ T-cells. This interaction with a T-cell's receptor may result in activation, but, if recognition occurs without collateral molecular interactions which cause ‘co-stimulation’, these T-cells will be tolerized.
openaire   +3 more sources

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1 [PDF]

Nature, 1993
The three-dimensional structure of the class II histocompatibility glycoprotein HLA-DR1 from human B-cell membranes has been determined by X-ray crystallography and is similar to that of class I HLA. Peptides are bound in an extended conformation that projects from both ends of an 'open-ended' antigen-binding groove.
Jack L. Strominger, Lawrence J. Stern, Lawrence J. Stern, Jerry H. Brown, Joan C. Gorga, Joan C. Gorga, Don C. Wiley, Don C. Wiley, Theodore S. Jardetzky, Robert G. Urban   +9 more
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Major histocompatibility complex class II‐restricted presentation of a cytosolic antigen by autophagy

European Journal of Immunology, 2003
AbstractBiochemical and functional studies have demonstrated major histocompatibility complex (MHC) class II‐restricted presentation of peptides derived from cytosolic proteins, but the underlying processing and presentation pathways have remained elusive.
Nimmerjahn, F., Milosevic, S., Behrends, U., Jaffee, E.M., Pardoll, D.M., Bornkamm, G.W., Mautner, J.   +6 more
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Expression of class I and class II major histocompatibility complex antigens on epithelial cells in recurrent aphthous stomatitis.

Journal of oral pathology, 1986
The concept of an immunopathogenesis in the establishment and progression of the recurrent aphthous stomatitis (RAS) lesion is well accepted. In this study the expression of Class I and Class II major histocompatibility complex (MHC) antigens on the ...
N. Savage, G. Seymour, B. Kruger
semanticscholar   +1 more source

Major Histocompatibility Complex Class II Antigen Presentation in Hodgkin's Disease

Leukemia & Lymphoma, 1999
The malignant cells in Hodgkin's disease (HD), commonly referred to as Hodgkin and Reed-Sternberg (HRS) cells, express major histocompatibility complex (MHC) class II molecules and, like "professional" antigen-presenting cells (APCs), different accessory or costimulatory molecules which can provide an additional activation signal to T cells.
openaire   +3 more sources

EXPRESSION OF CLASS II MAJOR HISTOCOMPATIBILITY ANTIGENS BY KERATINOCYTES IN CUTANEOUS T CELL LYMPHOMA

International Journal of Dermatology, 1994
Abstract Background. Expression of various class II MHC antigens by lesional keratinocytes may play an important role in the pathophysiology of a wide variety of human dermatoses including cutaneous T cell lymphoma (CTCL). Nevertheless, there is relatively little information available concerning the concurrent expression of HLA‐DR, ‐DP, and ‐DO class ...
Faith Durden, Richard T. Hoppe, Sara A. Michie, Roger A. Warnke, Gary S. Wood   +4 more
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Intrathyroidal Mast Cells Express Major Histocompatibility Complex Class-II Antigens

International Archives of Allergy and Immunology, 1989
We studied the expression of major histocompatibility complex (MHC) class-II antigen in mast cells of rat thyroid glands. In the normal rat thyroid, mast cells express MHC class-II antigen. In BioBreeding Wistar (BB/W) rats, the strain of animals prone to develop spontaneous autoimmune thyroiditis, the number of MHC class-II-positive mast cells was ...
J. Leone, D. Neylan, A. Rabinovitch, Latifa Ghandur-Mnaymneh, K. Banovac   +4 more
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Human retroplacental sera inhibit the expression of class II major histocompatibility antigens

Journal of Reproductive Immunology, 1986
Since factor(s) present in human pregnancy sera may interfere with HLA-DR expression on antigen-presenting cells which could account for fetal immune tolerance, we decided to investigate HLA-DR expression on the human myeloid macrophage cell line U937 using the monoclonal antibody RF DR2 and flow cytometry.
G.S. Panayi, N.S. Nicholas, John R. Murphy, Costantino Pitzalis   +3 more
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Processing and Presentation of Antigen by the Class II Histocompatibility System

2010
1 Introduction 2 The Innate System of Defense, APCs, and Symbiosis with T Cells 3 Antigen Presentation in Thymus and Peripheral Lymphoid Organs 4 MHCII Molecules 5 Stages in Antigen Presentation 6 APC Interactions with T Cells Keywords: innate system of defense, APCs, and T cell symbiosis; antigen presentation in thymus ...
openaire   +2 more sources