Results 41 to 50 of about 453,877 (390)
Expression of class I and class II major histocompatibility antigens on human hepatocellular carcinoma. [PDF]
Journal of Clinical Investigation, 1989 Previous reports indicate that human hepatocytes do not express class I and class II MHC antigens. Our analyses on 10 human hepatocellular carcinoma (HCC) cell lines by immunofluorescence tests and RIA, demonstrate that all the human HCC cell lines tested express class I MHC antigens and among them, three poorly differentiated human HCC cell lines also
S H Han +8 more
openaire +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 1989 To examine the effects of aberrant expression of class II major histocompatibility complex (MHC) proteins on tolerance development, transgenic mice expressing the I-Ad genes under control of the pancreatic elastase promoter were produced. Such transgenic
K. Murphy +4 more
semanticscholar +1 more source
Thymic selection of T-cell receptors as an extreme value problem [PDF]
Phys. Rev. Lett. 103 (2009) 068103, 2009 T lymphocytes (T cells) orchestrate adaptive immune responses upon activation. T cell activation requires sufficiently strong binding of T cell receptors (TCRs) on their surface to short peptides (p) derived from foreign proteins, which are bound to major histocompatibility (MHC) gene products (displayed on antigen presenting cells). A diverse and self-
arxiv +1 more source
Is There any Greater Possibility in Finding HLA-identical Unrelated Hematopoietic Stem Cell Donors among Thalassemia Families for Transplantation of Thalassemia Patients? [PDF]
International Journal of Hematology-Oncology and Stem Cell Research, 2004 Background: Thalassemia is probably the most common single gene disorder causing a major public health problem in the world. Currently, allogenic hematopoietic stem cell transplantation (HSCT) is the only curative therapy for thalassemia.
M Mohyeddin +5 more
doaj +1 more source
The influence of T cell development on pathogen specificity and autoreactivity [PDF]
J. Stat. Phys. 149 (2012) 203-219, 2011 T cells orchestrate adaptive immune responses upon activation. T cell activation requires sufficiently strong binding of T cell receptors on their surface to short peptides derived from foreign proteins bound to protein products of the major histocompatibility (MHC) gene products, which are displayed on the surface of antigen presenting cells.
arxiv +1 more source
HLA predictions from the bronchoalveolar lavage fluid samples of five patients at the early stage of the Wuhan seafood market COVID-19 outbreak [PDF]
Bioinformatics, btaa756 (2020), 2020 We are in the midst of a global viral pandemic, one with no cure and a high mortality rate. The Human Leukocyte Antigen (HLA) gene complex plays a critical role in host immunity. We predicted HLA class I and II alleles from the transcriptome sequencing data prepared from the bronchoalveolar lavage fluid samples of five patients at the early stage of ...
arxiv +1 more source
Functional Characterization of a Chicken Major Histocompatibility Complex Class II B Gene Promoter [PDF]
, 1997 A 0.7 kilobase (kb) DNA fragment from the 5\u27 flanking region of a chicken major histocompatibility complex (MHC) class II B gene was cloned into chloramphenicol acetyltransferase (CAT) reporter vectors and was transfected into a chicken macrophage ...
Carpenter, Susan +5 more
core +3 more sources
Antigen Presentation in the Gut
Canadian Journal of Gastroenterology, 1990 The induction of T cell responses requires recognition of antigens in association with class II major histocompatibility complex (MHC) proteins and specialized antigen-presenting cells.
W Doe, P Pavli
doaj +1 more source
Journal of Investigative Dermatology, 1987 Fifty-eight scalp biopsies were immunohistologically investigated with monoclonal antibodies against HLA-ABC, HLA-DR, and T6 antigens. The following 3 groups were compared: control biopsies obtained from healthy volunteers (n = 5) or patients with ...
E. Bröcker +3 more
semanticscholar +1 more source
Learning a peptide-protein binding affinity predictor with kernel ridge regression [PDF]
BMC Bioinformatics 2013, 14:82, 2012 We propose a specialized string kernel for small bio-molecules, peptides and pseudo-sequences of binding interfaces. The kernel incorporates physico-chemical properties of amino acids and elegantly generalize eight kernels, such as the Oligo, the Weighted Degree, the Blended Spectrum, and the Radial Basis Function.
arxiv +1 more source