From secretome analysis to immunology: chitosan induces major alterations in the activation of dendritic cells via a TLR4-dependent mechanism [PDF]
Mol Cell Proteomics 8, 6 (2009) 1252-64, 2009 Dendritic cells are known to be activated by a wide range of microbial products, leading to cytokine production and increased levels of membrane markers such as major histocompatibility complex class II molecules. Such activated dendritic cells possess the capacity to activate na\"ive T cells.
arxiv +1 more source
Histocompatibility testing in patients with carcinoma of the bladder [PDF]
Cancer, 1983 A number of disease states have been found to have a positive association with certain HLA antigens. Weak associations have been described for a number of cancers. Seventy patients with transitional cell carcinoma of the bladder underwent serotyping for HLA, A, B, C, and DR antigens. There were 54 men and 16 women patients with a mean age of 65.3 years.
Bernard Lytton +4 more
openaire +3 more sources
In Silico Derivation of HLA-Specific Alloreactivity Potential from Whole Exome Sequencing of Stem Cell Transplant Donors and Recipients: Understanding the Quantitative Immuno-biology of Allogeneic Transplantation [PDF]
Frontiers in Immunology 2014. 5:529, 2014 Donor T cell mediated graft vs. host effects may result from the aggregate alloreactivity to minor histocompatibility antigens (mHA) presented by the HLA in each donor-recipient pair (DRP) undergoing stem cell transplantation (SCT). Whole exome sequencing has demonstrated extensive nucleotide sequence variation in HLA-matched DRP. Non-synonymous single
arxiv +1 more source
Identifying a Minor Histocompatibility Antigen in Mauritian Cynomolgus Macaques Encoded by APOBEC3C
Frontiers in Immunology, 2020 Allogeneic hematopoietic stem cell transplants can lead to dramatic reductions in human immunodeficiency virus (HIV) reservoirs. This effect is partially mediated by donor T cells recognizing lymphocyte-expressed minor histocompatibility antigens (mHAgs).
Jason T. Weinfurter +9 more
doaj +1 more source
Prediction of a T-cell/MHC-I-based immune profile for colorectal liver metastases from CT images using ensemble learning [PDF]
arXiv, 2023 Colorectal cancer liver metastases (CLM) are the most common type of distant metastases originating from the abdomen and are characterized by a high recurrence rate after curative resection. It has been previously reported that CLM presenting a low cluster of differentiation 3 (CD3) positive T-cell infiltration density concurrent with a high major ...
arxiv
Thymic selection of T-cell receptors as an extreme value problem [PDF]
Phys. Rev. Lett. 103 (2009) 068103, 2009 T lymphocytes (T cells) orchestrate adaptive immune responses upon activation. T cell activation requires sufficiently strong binding of T cell receptors (TCRs) on their surface to short peptides (p) derived from foreign proteins, which are bound to major histocompatibility (MHC) gene products (displayed on antigen presenting cells). A diverse and self-
arxiv +1 more source
The influence of T cell development on pathogen specificity and autoreactivity [PDF]
J. Stat. Phys. 149 (2012) 203-219, 2011 T cells orchestrate adaptive immune responses upon activation. T cell activation requires sufficiently strong binding of T cell receptors on their surface to short peptides derived from foreign proteins bound to protein products of the major histocompatibility (MHC) gene products, which are displayed on the surface of antigen presenting cells.
arxiv +1 more source
Predicting the Binding of SARS-CoV-2 Peptides to the Major Histocompatibility Complex with Recurrent Neural Networks [PDF]
arXiv, 2021 Predicting the binding of viral peptides to the major histocompatibility complex with machine learning can potentially extend the computational immunology toolkit for vaccine development, and serve as a key component in the fight against a pandemic. In this work, we adapt and extend USMPep, a recently proposed, conceptually simple prediction algorithm ...
arxiv
Inferring HIV escape rates from multi-locus genotype data [PDF]
Front. Immunol. 4:252. 2013, 2013 Cytotoxic T-lymphocytes (CTLs) recognize viral protein fragments displayed by major histocompatibility complex (MHC) molecules on the surface of virally infected cells and generate an anti-viral response that can kill the infected cells. Virus variants whose protein fragments are not efficiently presented on infected cells or whose fragments are ...
arxiv +1 more source
Population variability in the generation and thymic selection of T-cell repertoires [PDF]
PLoS Computational Biology 16(12) e1008394 (2020), 2020 The diversity of T-cell receptor (TCR) repertoires is achieved by a combination of two intrinsically stochastic steps: random receptor generation by VDJ recombination, and selection based on the recognition of random self-peptides presented on the major histocompatibility complex.
arxiv +1 more source