Results 111 to 120 of about 557,726 (316)

Mutations to the histone H3 alpha N region selectively alter the outcome of ATP-dependent nucleosome-remodelling reactions [PDF]

, 2009
Mutational analysis of the histone H3 N-terminal region has shown it to play an important role both in chromatin function in vivo and nucleosome dynamics in vitro.
Owen-Hughes, Tom; id_orcid, Somers, Joanna   +1 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer [PDF]

, 2008
Background Enhanced activity of histone deacetylases (HDAC) is associated with more aggressive tumour behaviour and tumour progression in various solid tumours.
Dietel Manfred, Fritzsche, Florian R., Weichert Wilko, Gekeler Volker, Dietel, Manfred, Fritzsche Florian R, Beckers Thomas, Kristiansen Glen, Jung, Klaus, Kristiansen, Glen, Weichert, Wilko, Jung Klaus, Scholman Katharina, Gekeler, Volker, Denkert Carsten, Röske, Annika, Röske Annika, Beckers, Thomas, Stephan, Carsten, Stephan Carsten, Scholman, Katharina, Denkert, Carsten Michael   +21 more
core   +1 more source

A Potential Role for Epigenetic Processes in the Acclimation Response to Elevated pCO2 in the Model Diatom Phaeodactylum tricornutum

Frontiers in Microbiology, 2019
Understanding of the molecular responses underpinning diatom responses to ocean acidification is fundamental for predicting how important primary producers will be shaped by the continuous rise in atmospheric CO2.
Ruiping Huang, Jiancheng Ding, Kunshan Gao, Maria Helena Cruz de Carvalho, Maria Helena Cruz de Carvalho, Leila Tirichine, Chris Bowler, Xin Lin   +7 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Down-regulation of the histone methyltransferase EZH2 contributes to the epigenetic programming of decidualizing human endometrial stromal cells [PDF]

, 2011
Differentiation of human endometrial stromal cells (HESC) into decidual cells represents a highly coordinated process essential for embryo implantation. We show that decidualizing HESC down-regulate the histone methyltransferase enhancer of Zeste homolog
Poutanen, Matti, Henriet, Patrick, Giulia Grimaldi, Poutanen, Matti,, Steel, Jennifer H., Steel, Jennifer H, Jan J. Brosens, Matti Poutanen, Brosens, Jan J., Christian, Mark, Brosens, Jan J, Mark Christian, Grimaldi, Giulia, Jennifer H. Steel, Patrick Henriet   +14 more
core   +1 more source

Histone H1, the Forgotten Histone [PDF]

Epigenomics, 2019
Brockers, K., Schneider, R.
openaire   +3 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Global Analysis of the Relationship between JIL-1 Kinase and Transcription [PDF]

, 2010
The ubiquitous tandem kinase JIL-1 is essential for Drosophila development. Its role in defining decondensed domains of larval polytene chromosomes is well established, but its involvement in transcription regulation has remained controversial.
Regnard Catherine, Peter B Becker, Mitterweger Angelika, Ina K. Dahlsveen, Becker Peter B., Tobias Straub, Straub, Tobias, Peter B, Regnard, Catherine, Fabian Viola, Mitterweger, Angelika, Ina K Dahlsveen, Peter B. Becker, Dahlsveen Ina K., Becker, Peter B., Fabian, Viola, Dahlsveen, Ina K., Catherine Regnard, Angelika Mitterweger, Viola Fabian, Straub Tobias   +20 more
core   +2 more sources

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source