Results 121 to 130 of about 724,595 (331)
Molecular Oncology, EarlyView.Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi +12 more
wiley +1 more source
Histone deacetylation: Establishing a meiotic histone code [PDF]
Cell Cycle, 2014 Histone posttranslational modifications are essential for the control of gene expression, chromatin structure, and genome integrity. Genome-wide histone modifications induce changes in large-scale chromatin structure leading to the formation of distinct chromosomal domains that are heritable through mitosis and essential for cell division. Transmission
openaire +2 more sources
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer
Cells, 2019 Histone ubiquitination is a critical epigenetic mechanism regulating DNA-driven processes such as gene transcription and DNA damage repair. Importantly, the cellular machinery regulating histone ubiquitination is frequently altered in cancers.
Lucile M-P Jeusset, Kirk J McManus
doaj +1 more source
A MICROPHOTOMETRIC STUDY OF THE SYNTHESES OF DESOXYRIBONUCLEIC ACID AND NUCLEAR HISTONE [PDF]
, 1955 David P. Bloch, Gabriel C. Godman
openalex +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Neutrophil elastase is the 'histone H2A-specific protease' [PDF]
, 2011 Fundamental changes in the epigenetic status of histones from hematopoietic stem cells might be one of the driving forces behind many malignant transformations and subsequent leukemia development.
Deforce, Dieter +6 more
core +1 more source
Histones of Mitosis and Meiosis in Loxa flavicolis (Hemipteran) [PDF]
, 1958 Hudson R. Ansley
openalex +1 more source