Results 71 to 80 of about 557,726 (316)

Histones and histone variant families in prokaryotes

Nature Communications
AbstractHistones are important chromatin-organizing proteins in eukaryotes and archaea. They form superhelical structures around which DNA is wrapped. Recent studies have shown that some archaea and bacteria contain alternative histones that exhibit different DNA binding properties, in addition to highly divergent sequences.
Samuel Schwab, Yimin Hu, Bert van Erp, Marc K. M. Cajili, Marcus D. Hartmann, Birte Hernandez Alvarez, Vikram Alva, Aimee L. Boyle, Remus T. Dame   +8 more
openaire   +6 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Suv4-20h Histone Methyltransferases Promote Neuroectodermal Differentiation by Silencing the Pluripotency-Associated Oct-25 Gene [PDF]

, 2013
Post-translational modifications (PTMs) of histones exert fundamental roles in regulating gene expression. During development, groups of PTMs are constrained by unknown mechanisms into combinatorial patterns, which facilitate transitions from uncommitted
Jung, Julia, Gunnar Schotta (116394), Matthias Hahn (209009), Tobias D Schneider, Schneider, Tobias D., Tobias Straub, Straub, Tobias, Rupp, Ralph A. W., Matthias Hahn, Julia Jung, Ralph A W Rupp, Tobias D. Schneider (212729), Robert David (212736), Nicetto, Dario, Dario Nicetto, Tobias Straub (55423), Dario Nicetto (212737), Hahn, Matthias, Schotta, Gunnar, Robert David, Ralph A. W. Rupp (212738), Julia Jung (278298), Gunnar Schotta, David, Robert   +23 more
core   +2 more sources

Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer

Cells, 2019
Histone ubiquitination is a critical epigenetic mechanism regulating DNA-driven processes such as gene transcription and DNA damage repair. Importantly, the cellular machinery regulating histone ubiquitination is frequently altered in cancers.
Lucile M-P Jeusset, Kirk J McManus
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression [PDF]

, 2012
Chemical inhibitors of histone deacetylase (HDAC) activity are used as experimental tools to induce histone hyperacetylation and deregulate gene transcription, but it is not known whether the inhibition of HDACs plays any part in the normal physiological
Sproul, Duncan, Mackay, Logan, Culley, Jayne, Ramsahoye, Bernard H, Langridge-Smith, Pat, Gilbert, Nick, Harrison, David J, Latham, Tom, Hayward, Larry, Ramsahoye, Bernard H., Karim, Muhammed, Harrison, David J.   +11 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Fine mapping of posttranslational modifications of the linker histone H1 from Drosophila melanogaster. [PDF]

, 2008
The linker histone H1 binds to the DNA in between adjacent nucleosomes and contributes to chromatin organization and transcriptional control. It is known that H1 carries diverse posttranslational modifications (PTMs), including phosphorylation, lysine ...
Villar-Garea, Ana, Imhof, Axel, Axel Imhof, Ana Villar-Garea   +3 more
core   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

BRCA1 is a histone-H2A-specific ubiquitin ligase [PDF]

, 2014
The RING domain proteins BRCA1 and BARD1 comprise a heterodimeric ubiquitin (E3) ligase that is required for the accumulation of ubiquitin conjugates at sites of DNA damage and for silencing at DNA satellite repeat regions. Despite its links to chromatin,
Donna L. Mallery, Mallery, D., Conor Larkin, Huang, Jeffrey T.J., Kalb, R., Kevin Hiom, Kalb, Reinhard, Reinhard Kalb, Huang, Jeffrey T. J.; id_orcid, Hiom, Kevin, Hiom, K., Jeffrey T.J. Huang, Larkin, C., Mallery, Donna L., Larkin, Conor, Huang, J.   +15 more
core   +1 more source