Change Point Analysis of Histone Modifications Reveals Epigenetic Blocks Linking to Physical Domains [PDF]
arXiv, 2013 Histone modification is a vital epigenetic mechanism for transcriptional control in eukaryotes. High-throughput techniques have enabled whole-genome analysis of histone modifications in recent years. However, most studies assume one combination of histone modification invariantly translates to one transcriptional output regardless of local chromatin ...
arxiv
Arginine-Phosphate Salt Bridges Between Histones and DNA: Intermolecular Actuators that Control Nucleosome Architecture [PDF]
, 2014 Structural bioinformatics and van der Waals density functional theory are combined to investigate the mechanochemical impact of a major class of histone-DNA interactions, namely the formation of salt bridges between arginine residues in histones and phosphate groups on the DNA backbone.
arxiv +1 more source
From supramolecular chemistry to the nucleosome: studies in biomolecular recognition
Beilstein Journal of Organic Chemistry, 2016 This review highlights the author’s indirect path to research at the interface of supramolecular chemistry and chemical biology.
Marcey L. Waters
doaj +1 more source
Mapping Influenza-Induced Posttranslational Modifications on Histones from CD8+ T Cells
Viruses, 2020 T cell function is determined by transcriptional networks that are regulated by epigenetic programming via posttranslational modifications (PTMs) to histone proteins and DNA.
Svetlana Rezinciuc +5 more
doaj +1 more source
Minimal Cylinder Analysis Reveals the Mechanical Properties of Oncogenic Nucleosomes [PDF]
, 2019 Histone variants regulate replication, transcription, DNA damage repair, and chromosome segregation. Though widely accepted as a paradigm, it has not been rigorously demonstrated that histone variants encode unique mechanical properties. Here, we present a new theoretical approach called Minimal Cylinder Analysis (MCA) to determine the Young's modulus ...
arxiv +1 more source
Erasers of histone acetylation: the histone deacetylase enzymes.
Cold Spring Harbor Perspectives in Biology, 2014 Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl functional groups from the lysine residues of both histone and nonhistone proteins.
E. Seto, Minoru Yoshida
semanticscholar +1 more source
Molecules, 2018 With the increasing interest in scarce proteins, reducing the sample volume for circular dichroism (CD) spectroscopy has become desirable. Demagnification of the incident beam size is required to reduce the sample volume for CD spectroscopy detecting ...
Yudai Izumi, Koichi Matsuo
doaj +1 more source
Lysine methyltransferase SETD6 modifies histones on a glycine-lysine motif
Epigenetics, 2020 Although central to regulating the access to genetic information, most lysine methyltransferases remain poorly characterised relative to other family of enzymes. Herein, I report new substrates for the lysine methyltransferase SETD6.
Olivier Binda
doaj +1 more source
Study the effects of metallic ions on the combination of DNA and histones with molecular combing technique [PDF]
Chinese Science Bulletin, Vol.50, No. 8 (2005) 731-737, 2005 The effects of monovalent (Na+, K+) and divalent (Mg2+, Ca2+, Mn2+) ions on the interaction between DNA and histone are studied using the molecular combing technique. Lamda-DNA molecules and DNA-histone complexes incubated with metal cations (Na+, K+, Mg2+, Ca2+, Mn2+) are stretched on hydrophobic surfaces, and directly observed by fluorescence ...
arxiv
Epigenetic Alterations in Human Papillomavirus-Associated Cancers
Viruses, 2017 Approximately 15–20% of human cancers are caused by viruses, including human papillomaviruses (HPVs). Viruses are obligatory intracellular parasites and encode proteins that reprogram the regulatory networks governing host cellular signaling pathways ...
David Soto +2 more
doaj +1 more source