Results 61 to 70 of about 421 (119)
A specific role for importin-5 and NASP in the import and nuclear hand-off of monomeric H3
eLife, 2022 Core histones package chromosomal DNA and regulate genomic transactions, with their nuclear import and deposition involving importin-β proteins and a dedicated repertoire of histone chaperones. Previously, a histone H3-H4 dimer has been isolated bound to
Alonso Javier Pardal +1 more
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Histone chaperones: Variety and functions
Moscow University Biological Sciences Bulletin, 2016 Histone chaperones are required for the formation of the nucleosome—the basic unit of chromatin that consists of the DNA and histones. In this review, participation of histone chaperones CAF-1, ASF1, NAP1, and FACT in key cellular processes is discussed.
M. E. Valieva +2 more
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A potential histone-chaperone activity for the MIER1 histone deacetylase complex
Nucleic Acids Research, 2023 Abstract Histone deacetylases 1 and 2 (HDAC1/2) serve as the catalytic subunit of six distinct families of nuclear complexes. These complexes repress gene transcription through removing acetyl groups from lysine residues in histone tails.
Wang, S. +7 more
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High-resolution visualization of H3 variants during replication reveals their controlled recycling
Nature Communications, 2018 Epigenetic modifications are a key contributor to cell identity, and their propagation is crucial for proper development. Here the authors use a super-resolution microscopy approach to reveal how histone variants are faithfully transmitted during genome ...
Camille Clément +10 more
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Histone H3-K56 Acetylation Is Catalyzed by Histone Chaperone-Dependent Complexes [PDF]
Molecular Cell, 2007 Acetylation of histone H3 on lysine 56 occurs during mitotic and meiotic S phase in fungal species. This acetylation blocks a direct electrostatic interaction between histone H3 and nucleosomal DNA, and the absence of this modification is associated with extreme sensitivity to genotoxic agents.
Tsubota, Toshiaki +7 more
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DNA Repair Factor APLF Is a Histone Chaperone [PDF]
Molecular Cell, 2011 Poly(ADP-ribosyl)ation plays a major role in DNA repair, where it regulates chromatin relaxation as one of the critical events in the repair process. However, the molecular mechanism by which poly(ADP-ribose) modulates chromatin remains poorly understood.
Mehrotra, Pawan Vinod +7 more
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Histone Chaperones Nap1 and Vps75 Regulate Histone Acetylation during Transcription Elongation [PDF]
Molecular and Cellular Biology, 2013 Histone chaperones function in chromatin assembly and disassembly, suggesting they have important regulatory roles in transcription elongation. The Saccharomyces cerevisiae proteins Nap1 and Vps75 are structurally related, evolutionarily conserved histone chaperones.
Yu-Ming, Xue +6 more
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ATAD2 mediates chromatin-bound histone chaperone turnover
eLifeATAD2, a conserved protein which is predominantly expressed in embryonic stem (ES) cells and spermatogenic cells, emerges as a crucial regulator of chromatin plasticity. Our previous parallel studies conducted in both ES cells and S.
Ariadni Liakopoulou +13 more
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Structural insights into histone chaperone Chz1-mediated H2A.Z recognition and histone replacement.
PLoS Biology, 2019 Chz1 is a specific chaperone for the histone variant H2A.Z in budding yeast. The ternary complex formed by Chz1 and H2A.Z-H2B dimer is the major in vivo substrate of Swi2/snif2-related 1 (SWR1), the ATP-dependent chromatin remodeling enzyme that deposits
Yunyun Wang +10 more
doaj +1 more source
Biology Open, 2019 Cell-fate maintenance is important to preserve the variety of cell types that are essential for the formation and function of tissues. We previously showed that the acetylated histone-binding protein BET-1 maintains cell fate by recruiting the histone ...
Yukimasa Shibata +2 more
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