Results 71 to 80 of about 421 (119)

Histone binding of ASF1 is required for fruiting body development but not for genome stability in the filamentous fungus Sordaria macrospora

mBio
The highly conserved eukaryotic histone chaperone ASF1 is involved in the assembly and disassembly of nucleosomes during transcription, DNA replication, and repair. It was the first chaperone discovered to be involved in all three of these processes. The
Jan Breuer, Tobias Busche, Jörn Kalinowski, Minou Nowrousian   +3 more
doaj   +1 more source

Genome-wide chromatin accessibility is restricted by ANP32E

Nature Communications, 2020
Chromatin state underlies cellular function, and transcription factor binding patterns along with epigenetic marks define chromatin state. Here the authors show that the histone chaperone ANP32E functions through regulation of H2A.Z to restrict genome ...
Kristin E. Murphy, Fanju W. Meng, Claire E. Makowski, Patrick J. Murphy   +3 more
doaj   +1 more source

Histone chaperone Nap1 facilitates histone dynamics in the nucleosome

The FASEB Journal, 2018
We developed a single‐molecule FRET (smFRET) experimental system with which we can separately monitor histone H2A‐H2B dimer dynamics and DNA dynamics within a nucleosome particle. Utilizing the system, we monitored the nucleosome dynamics in the presence of histone chaperone Nap1 in order to investigate how the chaperone alters the dynamics of the ...
Tae‐Hee Lee, Jaehyoun Lee
openaire   +1 more source

Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response

Nature Communications, 2019
The autophagy protein p62 undergoes liquid-liquid phase separation but how this is regulated is unclear. Here, the authors report that the histone chaperone DAXX interacts with p62 in the cytoplasm to drive its phase separation.
Yi Yang, Thea L. Willis, Robert W. Button, Conor J. Strang, Yuhua Fu, Xue Wen, Portia R. C. Grayson, Tracey Evans, Rebecca J. Sipthorpe, Sheridan L. Roberts, Bing Hu, Jianke Zhang, Boxun Lu, Shouqing Luo   +13 more
doaj   +1 more source

The Role of the MCM2-7 Helicase Subunit MCM2 in Epigenetic Inheritance

Biology
Recycling histone proteins from parental chromatin, a process known as parental histone transfer, is an important component in chromosome replication and is essential for epigenetic inheritance.
Jing Jia, Chuanhe Yu
doaj   +1 more source

A long non-coding RNA is required for targeting centromeric protein A to the human centromere

eLife, 2014
The centromere is a specialized chromatin region marked by the histone H3 variant CENP-A. Although active centromeric transcription has been documented for over a decade, the role of centromeric transcription or transcripts has been elusive.
Delphine Quénet, Yamini Dalal
doaj   +1 more source

Mechanistic models of asymmetric hand-over-hand translocation and nucleosome navigation by CMG helicase

Nature Communications
Faithful replication of eukaryotic chromatin requires the CMG helicase to translocate directionally along single-stranded DNA (ssDNA) while unwinding double-stranded DNA (dsDNA) and navigating nucleosomes.
Fritz Nagae, Yutaka Murata, Masataka Yamauchi, Shoji Takada, Tsuyoshi Terakawa   +4 more
doaj   +1 more source

Imaging the fate of histone Cse4 reveals de novo replacement in S phase and subsequent stable residence at centromeres

eLife, 2014
The budding yeast centromere contains Cse4, a specialized histone H3 variant. Fluorescence pulse-chase analysis of an internally tagged Cse4 reveals that it is replaced with newly synthesized molecules in S phase, remaining stably associated with ...
Jan Wisniewski, Bassam Hajj, Jiji Chen, Gaku Mizuguchi, Hua Xiao, Debbie Wei, Maxime Dahan, Carl Wu   +7 more
doaj   +1 more source

USP52 acts as a deubiquitinase and promotes histone chaperone ASF1A stabilization

Nature Communications, 2018
Histone chaperone ASF1A is often dysregulated in cancers, however the regulation of its abundance is unclear. Here, the authors show that USP52 promotes ASF1A stability through deubiquitination while impairment of this stability reduces breast ...
Shangda Yang, Ling Liu, Cheng Cao, Nan Song, Yuejiao Wang, Shuai Ma, Qi Zhang, Na Yu, Xiang Ding, Fuquan Yang, Shanshan Tian, Kai Zhang, Tao Sun, Jie Yang, Zhi Yao, Shaoyuan Wu, Lei Shi   +16 more
doaj   +1 more source

Structure of the Hir histone chaperone complex

Molecular Cell
The evolutionarily conserved HIRA/Hir histone chaperone complex and ASF1a/Asf1 co-chaperone cooperate to deposit histone (H3/H4)2 tetramers on DNA for replication-independent chromatin assembly. The molecular architecture of the HIRA/Hir complex and its mode of histone deposition have remained unknown.
Hee Jong, Kim, Mary R, Szurgot, Trevor, van Eeuwen, M Daniel, Ricketts, Pratik, Basnet, Athena L, Zhang, Austin, Vogt, Samah, Sharmin, Craig D, Kaplan, Benjamin A, Garcia, Ronen, Marmorstein, Kenji, Murakami   +11 more
openaire   +2 more sources