Results 101 to 110 of about 33,260 (245)
Histone chaperone exploits intrinsic disorder to switch acetylation specificity
Nature Communications, 2019 Histone chaperones have been shown to control the activity and specificity of histone-modifying enzymes. Here the authors establish a structural model of the acetyltransferase Rtt109 in complex with Asf1 and Vps75 and the histone dimer H3:H4, finding ...
Nataliya Danilenko +5 more
doaj +1 more source
Histone H3-K56 Acetylation Is Catalyzed by Histone Chaperone-Dependent Complexes [PDF]
Molecular Cell, 2007 Acetylation of histone H3 on lysine 56 occurs during mitotic and meiotic S phase in fungal species. This acetylation blocks a direct electrostatic interaction between histone H3 and nucleosomal DNA, and the absence of this modification is associated with extreme sensitivity to genotoxic agents.
Tsubota, Toshiaki +7 more
openaire +3 more sources
Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy
BMEMat, EarlyView.Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu +5 more
wiley +1 more source
Displacement of Histones at Promoters of \u3ci\u3eSaccharomyces cerevisiae\u3c/i\u3e Heat Shock Genes Is Differentially Associated with Histone H3 Acetylation [PDF]
, 2006 Chromatin remodeling at promoters of activated genes spans from mild histone modifications to outright displacement of nucleosomes in trans. Factors affecting these events are not always clear.
Erkina, Tamara Y., Erkine, Alexander M.
core +1 more source
DNA Repair Factor APLF Is a Histone Chaperone [PDF]
Molecular Cell, 2011 Poly(ADP-ribosyl)ation plays a major role in DNA repair, where it regulates chromatin relaxation as one of the critical events in the repair process. However, the molecular mechanism by which poly(ADP-ribose) modulates chromatin remains poorly understood.
Mehrotra, Pawan Vinod +7 more
openaire +4 more sources
The proteostasis network and its decline in ageing
, 2019 Ageing is a major risk factor for the development of many diseases, prominently including neurodegenerative disorders such as Alzheimer disease and Parkinson disease.
Hartl, F., Hipp, M., Kasturi, P.
core +1 more source
, 2014 Biochemical assays reveal that nucleosome maturation and chromatin remodelling by the motor protein Chd1 are distinct, separable enzymatic ...
Bouazoune, Karim, Kingston, Robert E
core +1 more source
Histone Chaperones Nap1 and Vps75 Regulate Histone Acetylation during Transcription Elongation [PDF]
Molecular and Cellular Biology, 2013 Histone chaperones function in chromatin assembly and disassembly, suggesting they have important regulatory roles in transcription elongation. The Saccharomyces cerevisiae proteins Nap1 and Vps75 are structurally related, evolutionarily conserved histone chaperones.
Yu-Ming, Xue +6 more
openaire +2 more sources
International Journal of Cancer, EarlyView.What's New? Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic precursor to multiple myeloma, sharing substantial genetic features with overt malignancy. Given evidence implicating autophagy in myeloma risk, this study examined whether genetic variations in autophagy‐related genes influence MGUS susceptibility.
José Manuel Sánchez‐Maldonado +54 more
wiley +1 more source
HIRA vs. DAXX: the two axes shaping the histone H3.3 landscape
Experimental and Molecular MedicineH3.3, the most common replacement variant for histone H3, has emerged as an important player in chromatin dynamics for controlling gene expression and genome integrity.
Jinmi Choi, Taewan Kim, Eun-Jung Cho
doaj +1 more source