Results 101 to 110 of about 17,972 (261)

Structure, localization and histone binding properties of nuclear-associated nucleosome assembly protein from Plasmodium falciparum

Malaria Journal, 2010
Background Nucleosome assembly proteins (NAPs) are histone chaperones that are crucial for the shuttling and incorporation of histones into nucleosomes.
Maier Alexander G, Brown Monica, Rug Melanie, Jain SK, Belrhali Hassan, Yogavel Manickam, Kumar Anuj, Gill Jasmita, Sharma Amit   +8 more
doaj   +1 more source

Biochemical, biophysical and functional characterization of histone chaperones [PDF]

, 2014
2014 Spring.Nucleosomes, the basic repeating unit of chromatin, are highly dynamic. Nucleosome dynamics allow for various cellular activities such as replication, recombination, transcription and DNA repair, while maintaining a high degree of DNA ...
Zhang, Ling, author, Stargell, Laurie, committee member, Krapf, Diego, committee member, van Orden, Alan, committee member, Luger, Karolin, advisor, Nyborg, Jennifer, committee member   +5 more
core  

dKDM5/LID regulates H3K4me3 dynamics at the transcription-start site (TSS) of actively transcribed developmental genes [PDF]

, 2012
H3K4me3 is a histone modification that accumulates at the transcription-start site (TSS) of active genes and is known to be important for transcription activation.
Ponsà-Cobas, Joan, Azorín, F., Azorín, Ferran, Sílvia Pérez-Lluch, Tomás Morán, Morán, Tomás, David Rossell, Lloret-Llinares, Marta, Joan Ponsa-Cobas, Rossell, David, Herbert Auer, Azorín, Fernando, Fernando Azorín, Marta Lloret-Llinares, Pérez-Lluch, Sílvia, Corominas, Montserrat, Montserrat Corominas, Auer, Herbert, Corominas, Montserrat (Corominas Guiu)   +18 more
core   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

Analysis of histone deposition on specific DNA elements in living mammalian cells

BioTechniques, 2003
DNA replication and repair involve the deposition of newly synthesized histones. After their deposition on a specific locus, histones are extensively modified on their protruding N-terminal tails to restore the histone code corresponding to this locus ...
Laetitia Daury, Didier Trouche
doaj   +1 more source

Histone H3 variants at the root of metastasis

Molecular & Cellular Oncology, 2020
Chromatin remodeling is at the root of any cell fate decision, laying the foundation for the necessary reprogramming to occur. Our work shows histone H3 variants as a new addition to the ever-growing body of epigenetic regulators, one that is essential ...
Didem Ilter, John Blenis, Ana P. Gomes
doaj   +1 more source

Assembly chaperones : a perspective

, 2013
The historical origins and current interpretation of the molecular chaperone concept are presented, with the emphasis on the distinction between folding chaperones and assembly chaperones.
Ellis, R. John
core   +1 more source

The Histone Chaperone Network Is Highly Conserved in Physarum polycephalum

, 2023
The nucleosome is composed of histones and DNA. Prior to their deposition on chromatin, histones are shielded by specialized and diverse proteins known as histone chaperones.
Jacob, Yannick, Christophe Thiriet, Yannick Jacob, Poulet, Axel, Stéphane Téletchéa, Céline Duc, Ellyn Rousselot, Téletchéa, Stéphane, Céline Noirot, Noirot, Céline, Josien van Wolfswinkel, Rousselot, Ellyn, Axel Poulet, Thiriet, Christophe, Duc, Céline, van Wolfswinkel, Josien   +15 more
core   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Saccharomyces cerevisiaehistone Chaperones FACT and Spt6 modulate Pol II and histone occupancy genome-wide

, 2018
Histone chaperones, chromatin remodelers, and histone modifying complexes play a critical role in alleviating the nucleosomal barrier. Here, we have examined the role of two highly conserved yeast (Saccharomyces cerevisiae) histone chaperones, FACT and ...
Sudha Ananthakrishnan, Chhabi K. Govind, Olivia Schimmel, Sarah Adamczyk, Rakesh Pathak, Priyanka Singh   +5 more
core   +1 more source