Results 131 to 140 of about 17,972 (261)

Histone chaperone Nap1 facilitates histone dynamics in the nucleosome

The FASEB Journal, 2018
We developed a single‐molecule FRET (smFRET) experimental system with which we can separately monitor histone H2A‐H2B dimer dynamics and DNA dynamics within a nucleosome particle. Utilizing the system, we monitored the nucleosome dynamics in the presence of histone chaperone Nap1 in order to investigate how the chaperone alters the dynamics of the ...
Tae‐Hee Lee, Jaehyoun Lee
openaire   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Nucleosome retention by histone chaperones and remodelers occludes pervasive DNA-protein binding. [PDF]

Nucleic Acids Res, 2023
Jonas F, Vidavski M, Benuck E, Barkai N, Yaakov G.   +4 more
europepmc   +1 more source

Nucleosome thermodynamics, histone modifications, and histone chaperone function

The FASEB Journal, 2010
Genome accessibility is regulated to a large part by the posttranslational modification of histones (PTM). Surprisingly, and despite the fact that nucleosomes were first characterized over 35 years ago, very little is known about the free energy required to assemble and maintain ...
Karolin Luger, Laurie A Stargell, Andrew J Andrews, Xu Chen, Alex Zevin   +4 more
openaire   +1 more source

Deciphering the soybean root rot pathogen Phytophthora sojae: Signaling pathways, transcriptional regulation, and effector biology

New Plant Protection, EarlyView.
This review highlights how Phytophthora sojae utilizes unconventional lineage‐specific signaling networks, including unique G protein‐coupled receptor fusions, expanded kinases, and rapidly evolving effectors, to infect soybeans. Understanding these divergent molecular paradigms reveals critical vulnerabilities in this destructive pathogen, offering ...
Min Qiu, Xiaoyi Zhang, Bo Yang, Wenwu Ye, Yuanchao Wang   +4 more
wiley   +1 more source

Optical mapping reveals a higher level of large‐scale structural variants in a family with paternally transmitted myotonic dystrophy and independent Parkinson's disease

The Journal of Pathology, EarlyView.
Abstract Myotonic dystrophy type 1 (DM1) is a clinically challenging multisystem neuromuscular hereditary disorder, with generational increase in severity and earlier age at onset. It is caused by an unstable cytosine‐thymine‐guanine repeat expansion at the DMPK locus, accompanied by associated genetic and epigenetic modifications.
Md Mehedi Hasan, Jenna Craddock, Tingting Gong, Ruth J Lyons, Igor Stevanovski, Sanjog R Chintalaphani, Ira W Deveson, Weerachai Jaratlerdsiri, Kishore R Kumar, Vanessa M Hayes   +9 more
wiley   +1 more source

UNCOVERING THE MECHANISM OF CHROMATIN ASSOCIATION OF THE PAF1 TRANSCRIPTION ELONGATION COMPLEX [PDF]

, 2013
Paf1C co-localizes with Pol II and influences gene expression by regulating transcription initiation, elongation and termination. Some crucial functions of Paf1C include promoting co-transcriptional histone modifications and recruiting termination ...
Mayekar, Manasi
core  

Transcriptome profiling reveals a novel role for trichostatin A in antagonizing histone chaperone Chz1 mediated telomere anti-silencing

, 2011
The histone chaperones play an important role in chromatin assembly and disassembly during replication and transcription. We have assessed the global roles of histone chaperones in Saccharomyces cerevisiae.
Wan, Yakun, Ramsey, Saleem, Saleem Ramsey, Xing, Jie, Tan, Jinyin, Huiying Chen, Chen, Huiying, Lin, Zhanxian, Chiang, Jung-Hsien, Li, Bing, Jie Xing, Jung-Hsien Chiang, Chen, Weiming, Weiming Chen, Bing Li, Jinyin Tan, Yakun Wan, Zhanxian Lin   +17 more
core   +1 more source

Multiple Roles of Protamine Kinase SRPK1 and Phosphatase PP1γ in Sperm Development

PROTEOMICS, EarlyView.
ABSTRACT Protein phosphorylation regulates key events of male germ cell differentiation. In the testis, SRPK1 and PP1γ are involved in protamine phosphorylation and dephosphorylation, respectively, and their deregulation is linked to defective chromatin structure and male infertility.
Alberto de la Iglesia, Mélina Blanco, Meritxell Jodar, Olivier Feudjio, Marjorie Leduc, Judit Castillo, Julie Cocquet, Rafael Oliva   +7 more
wiley   +1 more source

RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment

Precision Medical Sciences, EarlyView.
This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run, Shiwei Jiang, Kun Xu, Yu Fan, Yanwen Chen, Ziao Liu, Zengli Miao, Wei Tian   +7 more
wiley   +1 more source