Results 151 to 160 of about 17,972 (261)
The effects of the histone chaperone and histone modifications on nucleosome structure
, 2016 The nucleosome, composed of 147-bp DNA and a histone octamer, is the basic unit of chromatin in eukaryotes, which is considered as a barrier for all DNA dependent processes. Understanding how nucleosome structure is regulated provides new insights into pivotal cellular processes.
Wang, Tao, author +4 more
openaire +1 more source
, 2012 (A) Dia2 functions in parallel with known H3–H4 histone chaperones in transcriptional silencing at the silent HMR locus. Cells of the indicated genotype were assessed for HMR silencing as described in Figure 1A–1B.
Zhiguo Zhang (147197) +4 more
core +1 more source
The FEBS Journal, EarlyView.Congenital dyserythropoietic anemia type I (CDA‐I) arises from mutations in Codanin1 and CDIN1. Using quantitative biophysical approaches, we show that disease‐associated mutations disrupt the CDIN1‐Codanin1 complex. Our findings provide critical insights into the molecular mechanism that links protein dysfunction to disturbing chromatin arrangement ...
Martin Stojaspal +8 more
wiley +1 more source
Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones. [PDF]
Genes Dev, 2021 Liu CP +6 more
europepmc +1 more source
Contributions of DNA, histone chaperones and chromatin remodeling enzymes to nucleosome positioning. [PDF]
, 2009 The eukaryotic genome is packaged by wrapping ~147 bp units of DNA around histone octamers to form chains of nucleosomes. The packaging of the DNA within a nucleosome reduces access of the DNA to most transcription factors and polymerases.
Partensky, Peretz
core
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
The FEBS Journal, EarlyView.Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf +7 more
wiley +1 more source
Biogenesis of TNF‐α‐insights into proteostasis and inflammation
The FEBS Journal, EarlyView.TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar +3 more
wiley +1 more source
Histone chaperone regulates replication
The Journal of Cell Biology, 2008 Histone supply and demand are tightly coupled at the replication fork by a chaperone, according to Genevieve Almouzni (Curie Institute, Paris, France) and colleagues. The chaperone, Asf1, passes histones from parental to daughter DNA strands and unwinds just enough DNA to match its transfer activities.
openaire +2 more sources
The chaperone-histone partnership: for the greater good of histone traffic and chromatin plasticity
, 2011 Histones are highly positively charged proteins that wrap our genome. Their surface properties also make them prone to nonspecific interactions and aggregation.
Ladurner, Andreas G. +3 more
core +1 more source