Results 171 to 180 of about 33,260 (245)

O papel da trimetilação da histona H3 na transcrição [PDF]

, 2011
Tese de mestrado. Biologia (Biologia Molecular e Genética). Universidade de Lisboa, Faculdade de Ciências, 2011Os nucleossomas, unidades básicas da cromatina, formados por um octâmero de histonas em associação com um fragmento de DNA, possuem um papel de
Raposo, Ana Cláudia Bernardino, 1988-
core  

MicroRNA‐Mediated Regulation of Brain Aging Hallmarks: Implications for Neurodegeneration and Neural Recovery

Brain and Behavior, Volume 16, Issue 5, May 2026.
Hallmarks of brain aging regulated by microRNAs (miRNAs). This graphical abstract illustrates the central role of miRNAs in coordinating key biological processes associated with brain aging. miRNAs regulate multiple interconnected hallmarks, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis and impaired ...
Mustafa T. Ardah, Pareshkumar N. Patel, Omayma Salim Waleed, Jamuna K. V., Vandana Tripathi, L. Lakshmi, Rajashree Panigrahi, Manoj Kumar Mishra   +7 more
wiley   +1 more source

Intersecting Molecular Pathways in Cardiovascular Disease and Diabetes Mellitus: Emerging Roles of Inflammation and Therapeutics

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 4, May 2026.
Central illustration: Pathophysiological mechanisms linking diabetes mellitus and cardiovascular disease. Chronic hyperglycaemia, insulin resistance, and low‐grade inflammation contribute to endothelial dysfunction, myocardial fibrosis, and cardiomyocyte apoptosis.
Lilian Anagnostopoulou, Nikolaos Ktenopoulos, Anastasios Apostolos, Christos Fragoulis, Panayotis Vlachakis, Paschalis Karakasis, Marios Sagris, Nikias Milaras, Maria Drakopoulou, Andreas Synetos, Ioannis Kyriazis, Ioannis Ioannidis, Costas Tsioufis, Konstantinos Toutouzas   +13 more
wiley   +1 more source

An ALS‐associated mutation in the C‐terminal α‐helix of TDP‐43 uncouples condensate formation and amyloid assembly

Protein Science, Volume 35, Issue 5, May 2026.
Abstract TAR DNA‐binding protein 43 (TDP‐43) plays a critical role in RNA metabolism and is incorporated into biomolecular condensates called stress granules. In amyotrophic lateral sclerosis (ALS) and several other neurodegenerative disorders, TDP‐43 undergoes aberrant phase transitions, forming insoluble amyloid aggregates, including fibrils composed
Emily J. Byrd, Joel A. Crossley, Chalmers C. C. Chau, Paolo Actis, Antonio N. Calabrese   +4 more
wiley   +1 more source

The double histone fold: Structure, functional implications across the tree of life and relevance to protein design

Protein Science, Volume 35, Issue 5, May 2026.
Abstract The histone fold is one of the most ancient and versatile structural motifs in protein biology, best known for its role in chromatin organization. A remarkable variation of this motif is the double histone fold (DHF), in which two histone folds are encoded within a single polypeptide chain and assemble intramolecularly into a histone‐like ...
Anna Ranaudo, Toshiko Miyake, Ugo Cosentino, Claudio Greco   +3 more
wiley   +1 more source

Identification of distinct SET/TAF-Iβ domains required for core histone binding and quantitative characterisation of the interaction [PDF]

, 2009
Zoe Karetsou, Anastasia Emmanouilidou, Ioannis Sanidas, Stamatis Liokatis, Eleni Nikolakaki, Anastasia S Politou, Thomais Papamarcaki   +6 more
core   +1 more source

Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for Diabetes

Journal of Diabetes, Volume 18, Issue 5, May 2026.
This review highlights mitochondrial dysfunction as a central driver of pancreatic β cell failure in diabetes, caused by disrupted mitochondrial quality control (MQC), oxidative stress, and impaired organelle communication. Emerging therapies, such as DRAK2 inhibitors and metabolic reprogramming agents, show promise in restoring β cell function by ...
Ruihan Li, Bingqian Zhang, Yuxin Zhang, Yang Yang, Yuting Lu, Jingya Li   +5 more
wiley   +1 more source

Structure-function relationship of H2A-H2B specific plant histone chaperones. [PDF]

Cell Stress Chaperones, 2020
Kumar A, Vasudevan D.
europepmc   +1 more source

Inferring Gene Regulatory Network Architecture Underlying Complex Traits: An Integrative Analysis of Mutant Lifespan and Gene Expression Profiles Identifies Master Regulators and Key Functional Modules for Yeast Aging

Aging Cell, Volume 25, Issue 5, May 2026.
We developed a LASSO‐based approach to uncover a three‐layered “fan‐in fan‐out” network architecture for complex traits like yeast aging, showing that peripheral genes influence lifespan indirectly through master regulators, which converge on core functional modules (e.g., stress response, autophagy).
Meng Ma, Juan Long, Yuting Chen, Yanqiu Shao, Man Zhu, Jiashun Zheng, Lu Yang, Yin Xiao, Matt Kaeberlein, Brian K. Kennedy, Yi Zheng, Hao Li, Jing Yang   +12 more
wiley   +1 more source

Activities of Chromatin Remodeling Factors and Histone Chaperones and Their Effects in Root Apical Meristem Development. [PDF]

Int J Mol Sci, 2020
Kang H, Wu D, Fan T, Zhu Y.
europepmc   +1 more source