Results 51 to 60 of about 17,972 (261)
H3–H4 histone chaperones and cancer
Current Opinion in Genetics & Development, 2022 Histone chaperones are key regulators of chromatin structure and function. Their frequent mis-regulation in various cancers can impact tumor initiation and progression. Here, we focus on H3-H4 histone chaperones to highlight recent studies concerning their roles in several cancers thereby expanding on previous reports illustrating their functions as ...
Ray-Gallet, Dominique +1 more
openaire +3 more sources
ATP-dependent chromatosome remodeling [PDF]
, 2008 Chromatin serves to package, protect and organize the complex eukaryotic genomes to assure their stable inheritance over many cell generations. At the same time, chromatin must be dynamic to allow continued use of DNA during a cell's lifetime.
Chioda, Mariacristina +2 more
core +1 more source
Chz1, a Nuclear Chaperone for Histone H2AZ [PDF]
Molecular Cell, 2007 The histone variant H2AZ marks nucleosomes flanking the promoters of most genes of budding yeast. The incorporation of H2AZ into chromatin is dependent on the SWR1 complex, which catalyses the replacement of conventional histone H2A with H2AZ. In cells, the pool of unincorporated histone H2AZ has previously been found in association with Nap1, a ...
Luk, Ed +10 more
openaire +2 more sources
The Art of War: harnessing the epigenome against cancer [version 1; referees: 4 approved]
F1000Research, 2018 Histone chaperones are indispensable regulators of chromatin structure and function. Recent work has shown that they are frequently mis-regulated in cancer, which can have profound consequences on tumor growth and survival.
Jonathan Nye +2 more
doaj +1 more source
Inhibition of histone H3-H4 chaperone pathways rescues C. elegans sterility by H2B loss.
PLoS Genetics, 2022 Oncohistone mutations are crucial drivers for tumorigenesis, but how a living organism governs the loss-of-function oncohistone remains unclear. We generated a histone H2B triple knockout (3KO) strain in Caenorhabditis elegans, which decreased the ...
Ruixue Zhao +5 more
doaj +1 more source
ATRX limits the accessibility of histone H3-occupied HSV genomes during lytic infection.
PLoS Pathogens, 2021 Histones are rapidly loaded on the HSV genome upon entry into the nucleus of human fibroblasts, but the effects of histone loading on viral replication have not been fully defined.
Joseph M Cabral +3 more
doaj +1 more source
Regulation of replicative histone RNA metabolism by the histone chaperone ASF1
Molecular Cell, 2022 SUMMARY In S phase, duplication and assembly of the whole genome into chromatin requires upregulation of replicative histone gene expression. Here, we explored a potential role of histone chaperones in this process thereby linking chromatin assembly with histone production in human cells.
Mendiratta, Shweta +6 more
openaire +3 more sources
ATAD2 controls chromatin-bound HIRA turnover
Life Science Alliance, 2021 Parallel study of multiple model systems points to the evolutionary conserved protein ATAD2, as a critical histone chaperone auxiliary factor. Taking advantage of the evolutionary conserved nature of ATAD2, we report here a series of parallel functional ...
Tao Wang +17 more
doaj +1 more source
Histone Chaperones: Modulators of Chromatin Marks [PDF]
Molecular Cell, 2011 The many factors that control chromatin biology play key roles in essential nuclear functions like transcription, DNA damage response and repair, recombination, and replication and are critical for proper cell-cycle progression, stem cell renewal, differentiation, and development. These players belong to four broad classes: histone modifiers, chromatin
Avvakumov, Nikita +2 more
openaire +2 more sources
UBR7 acts as a histone chaperone for post‐nucleosomal histone H3
The EMBO Journal, 2021 Histone chaperones modulate the stability of histones beginning from histone synthesis, through incorporation into DNA, and during recycling during transcription and replication. Following histone removal from DNA, chaperones regulate histone storage and degradation.
Ann K Hogan +16 more
openaire +2 more sources