Histone Hypervariants H2A.Z.1 and H2A.Z.2 Play Independent and Context-Specific Roles in Neuronal Activity-Induced Transcription of Arc/Arg3.1 and Other Immediate Early Genes. [PDF]
, 2017 The histone variant H2A.Z is an essential and conserved regulator of eukaryotic gene transcription. However, the exact role of this histone in the transcriptional process remains perplexing.
Bailey, Emma R +7 more
core +1 more source
TRF1 and TRF2 binding to telomeres is modulated by nucleosomal organization [PDF]
, 2015 The ends of eukaryotic chromosomes need to be protected from the activation of a DNA damage response that leads the cell to replicative senescence or apoptosis.
Alicata, Claudia +8 more
core +3 more sources
The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis [PDF]
The EMBO Journal, 2013 Histone chaperones affect chromatin structure and gene expression through interaction with histones and RNA polymerase II (PolII). Here, we report that the histone chaperone Spt6 counteracts H3K27me3, an epigenetic mark deposited by the Polycomb Repressive Complex 2 (PRC2) and associated with transcriptional repression.
A Hongjun, Wang +8 more
openaire +2 more sources
The Art of War: harnessing the epigenome against cancer [version 1; referees: 4 approved]
F1000Research, 2018 Histone chaperones are indispensable regulators of chromatin structure and function. Recent work has shown that they are frequently mis-regulated in cancer, which can have profound consequences on tumor growth and survival.
Jonathan Nye +2 more
doaj +1 more source
Inhibition of histone H3-H4 chaperone pathways rescues C. elegans sterility by H2B loss.
PLoS Genetics, 2022 Oncohistone mutations are crucial drivers for tumorigenesis, but how a living organism governs the loss-of-function oncohistone remains unclear. We generated a histone H2B triple knockout (3KO) strain in Caenorhabditis elegans, which decreased the ...
Ruixue Zhao +5 more
doaj +1 more source
ATRX limits the accessibility of histone H3-occupied HSV genomes during lytic infection.
PLoS Pathogens, 2021 Histones are rapidly loaded on the HSV genome upon entry into the nucleus of human fibroblasts, but the effects of histone loading on viral replication have not been fully defined.
Joseph M Cabral +3 more
doaj +1 more source
Catalytic activation of histone acetyltransferase Rtt109 by a histone chaperone [PDF]
Proceedings of the National Academy of Sciences, 2010 Most histone acetyltransferases (HATs) function as multisubunit complexes in which accessory proteins regulate substrate specificity and catalytic efficiency. Rtt109 is a particularly interesting example of a HAT whose specificity and catalytic activity require association with either of two histone chaperones, Vps75 or Asf1.
Kolonko, Erin M. +8 more
openaire +3 more sources
Histone Variants and Their Chaperones in Hematological Malignancies
HemaSphere, 2023 Epigenetic regulation occurs on the level of compacting DNA into chromatin. The functional unit of chromatin is the nucleosome, which consists of DNA wrapped around a core of histone proteins.
Ecem Kirkiz +3 more
doaj +1 more source
The Histone Chaperones FACT and Spt6 Restrict H2A.Z from Intragenic Locations. [PDF]
Mol Cell, 2015 Jeronimo C +4 more
europepmc +2 more sources
A creature with a hundred waggly tails: intrinsically disordered proteins in the ribosome [PDF]
, 2013 This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Dunker, A. Keith +6 more
core +2 more sources