Results 61 to 70 of about 33,260 (245)
Chaperoning histones at the DNA repair dance
DNA Repair, 2021 Unlike all other biological molecules that are degraded and replaced if damaged, DNA must be repaired as chromosomes cannot be replaced. Indeed, DNA endures a wide variety of structural damage that need to be repaired accurately to maintain genomic stability and proper functioning of cells and to prevent mutation leading to disease.
Ujani Chakraborty +2 more
openaire +3 more sources
ATAD2 controls chromatin-bound HIRA turnover
Life Science Alliance, 2021 Parallel study of multiple model systems points to the evolutionary conserved protein ATAD2, as a critical histone chaperone auxiliary factor. Taking advantage of the evolutionary conserved nature of ATAD2, we report here a series of parallel functional ...
Tao Wang +17 more
doaj +1 more source
The transcription factor ATF5: role in cellular differentiation, stress responses, and cancer. [PDF]
, 2017 Activating transcription factor 5 (ATF5) is a cellular prosurvival transcription factor within the basic leucine zipper (bZip) family that is involved in cellular differentiation and promotes cellular adaptation to stress.
Angelastro, James M, Sears, Thomas K
core +2 more sources
Chaperoning Histones during DNA Replication and Repair [PDF]
Cell, 2010 Nuclear DNA is tightly packaged into chromatin, which profoundly influences DNA replication, transcription, repair, and recombination. The extensive interactions between the basic histone proteins and acidic DNA make the nucleosomal unit of chromatin a highly stable entity. For the cellular machinery to access the DNA, the chromatin must be unwound and
Ransom, Monica +2 more
openaire +2 more sources
Weakly positioned nucleosomes enhance the transcriptional competency of chromatin. [PDF]
PLoS ONE, 2010 Transcription is affected by nucleosomal resistance against polymerase passage. In turn, nucleosomal resistance is determined by DNA sequence, histone chaperones and remodeling enzymes.
Yaakov Belch +6 more
doaj +1 more source
New chaps in the histone chaperone arena [PDF]
Genes & Development, 2010 Understanding exactly how chromatin is assembled is paramount to addressing how select histone modifications may be transmitted, a putative epigenetic process. In the June 15, 2010, issue of Genes & Development, Drané and colleagues (pp. 1253–1265) identified DAXX as a novel H3.3-specific chaperone.
Eric I, Campos, Danny, Reinberg
openaire +2 more sources
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
PLoS Computational Biology, 2012 Histone chaperones facilitate assembly and disassembly of nucleosomes. Understanding the process of how histone chaperones associate and dissociate from the histones can help clarify their roles in chromosome metabolism.
Xiakun Chu +6 more
doaj +1 more source
The intrinsically disordered distal face of nucleoplasmin recognizes distinct oligomerization states of histones [PDF]
, 2013 The role of Nucleoplasmin (NP) as a H2A-H2B histone chaperone has been extensively characterized. To understand its putative interaction with other histone ligands, we have characterized its ability to bind H3-H4 and histone octamers.
Aloria, K +9 more
core +1 more source
Conservation of centromeric histone 3 interaction partners in plants [PDF]
, 2020 The loading and maintenance of centromeric histone 3 (CENH3) at the centromere are critical processes ensuring appropriate kinetochore establishment and equivalent segregation of the homologous chromosomes during cell division.
Geelen, Danny +3 more
core +1 more source