Results 61 to 70 of about 17,972 (261)

NAP1 Family Histone Chaperones Are Required for Somatic Homologous Recombination in Arabidopsis [PDF]

, 2012
International audienceHomologous recombination (HR) is essential for maintaining genome integrity and variability. To orchestrate HR in the context of chromatin is a challenge, both in terms of DNA accessibility and restoration of chromatin organization ...
Molinier, J., Gao, J., Dong, A., Zhu, Y., Zhou, W., Shen, W.H.   +5 more
core   +1 more source

Weakly positioned nucleosomes enhance the transcriptional competency of chromatin. [PDF]

PLoS ONE, 2010
Transcription is affected by nucleosomal resistance against polymerase passage. In turn, nucleosomal resistance is determined by DNA sequence, histone chaperones and remodeling enzymes.
Yaakov Belch, Jingyi Yang, Yang Liu, Sridhar A Malkaram, Rong Liu, Jean-Jack M Riethoven, Istvan Ladunga   +6 more
doaj   +1 more source

A potential histone-chaperone activity for the MIER1 histone deacetylase complex

Nucleic Acids Research, 2023
Abstract Histone deacetylases 1 and 2 (HDAC1/2) serve as the catalytic subunit of six distinct families of nuclear complexes. These complexes repress gene transcription through removing acetyl groups from lysine residues in histone tails.
Wang, S., Fairall, L., Pham, T.K., Ragan, T.J., Vashi, D., Collins, M.O., Dominguez, C., Schwabe, J.W.R.   +7 more
openaire   +3 more sources

Structural basis for histone H3 acetylation by Rtt109 in complex with histone chaperones Asf1 and Vps75

, 2020
In eukaryotes, genetic material is stored as chromatin, a DNA-protein complex whose structure is tightly regulated. Histones are the main protein components of chromatin and their post-translational modifications (PTMs) influence several cellular ...
Danilenko, Nataliya
core   +1 more source

Importance of electrostatic interactions in the association of intrinsically disordered histone chaperone Chz1 and histone H2A.Z-H2B.

PLoS Computational Biology, 2012
Histone chaperones facilitate assembly and disassembly of nucleosomes. Understanding the process of how histone chaperones associate and dissociate from the histones can help clarify their roles in chromosome metabolism.
Xiakun Chu, Yong Wang, Linfeng Gan, Yawen Bai, Wei Han, Erkang Wang, Jin Wang   +6 more
doaj   +1 more source

Histone Loaders CAF1 and HIRA Restrict Epstein-Barr Virus B-Cell Lytic Reactivation

mBio, 2020
Epstein-Barr virus (EBV) infects 95% of adults worldwide and causes infectious mononucleosis. EBV is associated with endemic Burkitt lymphoma, Hodgkin lymphoma, posttransplant lymphomas, nasopharyngeal and gastric carcinomas. In these cancers and in most
Yuchen Zhang, Chang Jiang, Stephen J. Trudeau, Yohei Narita, Bo Zhao, Mingxiang Teng, Rui Guo, Benjamin E. Gewurz   +7 more
doaj   +1 more source

Description of histone modifying enzymes and histone chaperones.

, 2012
Description of histone modifying enzymes and histone chaperones.
David Morse (14370), Sougata Roy (173348)   +1 more
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Identification of ASF1A and HJURP by global H3–H4 histone chaperone analysis as a prognostic two-gene model in hepatocellular carcinoma

Scientific Reports
Hepatocellular carcinoma (HCC) is a malignancy with poor prognosis. Abnormal expression of H3–H4 histone chaperones has been identified in many cancers and holds promise as a biomarker for diagnosis and prognosis.
Yongkang Liu, Shihui Liu, Rui Jing, Congcong Li, Yongqi Guo, Zhiye Cai, Pei Xi, Penggao Dai, Lintao Jia, Hongli Zhu, Xiang Zhang   +10 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source