Results 11 to 20 of about 123,729 (215)

Cancer cell histone density links global histone acetylation, mitochondrial proteome and histone acetylase inhibitor sensitivity

Communications Biology, 2022
Elevated histone density is associated with global histone acetylation, histone deacetylase inhibitor sensitivity and altered mitochondrial proteome composition, with histone regulator HMGB1 linked to histone density aberrations in many cancer cell lines.
Christopher Bruhn, Giulia Bastianello, Marco Foiani   +2 more
doaj   +1 more source

Chemical phylogenetics of histone deacetylases [PDF]

Nature Chemical Biology, 2010
The broad study of histone deacetylases in chemistry, biology and medicine relies on tool compounds to derive mechanistic insights. A phylogenetic analysis of class I and II histone deacetylases (HDACs) as targets of a comprehensive, structurally diverse panel of inhibitors revealed unexpected isoform selectivity even among compounds widely perceived ...
Bradner, James E., West, Nathan, Grachan, Melissa L., Greenberg, Edward F., Haggarty, Stephen J., Warnow, Tandy, Mazitschek, Ralph   +6 more
openaire   +2 more sources

Loss of deacetylation activity of Hdac6 affects emotional behavior in mice. [PDF]

PLoS ONE, 2012
Acetylation is mediated by acetyltransferases and deacetylases, and occurs not only on histones but also on diverse proteins. Although histone acetylation in chromatin structure and transcription has been well studied, the biological roles of non-histone
Masahide Fukada, Atsuko Hanai, Atsuo Nakayama, Takayoshi Suzuki, Naoki Miyata, Ramona M Rodriguiz, William C Wetsel, Tso-Pang Yao, Yoshiharu Kawaguchi   +8 more
doaj   +1 more source

Histone Deacetylases in Stroke

Chinese Journal of Physiology, 2019
Stroke is the second leading cause of death and the leading cause of adult disability worldwide. Despite an impressive amount of neuroprotective agents that has been identified in experimental stroke, none of them proved efficient in clinical trials. There is a general consensus that an effective treatment requires the ability
Mei-Han Kao, Teng-Nan Lin
openaire   +3 more sources

Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke [PDF]

, 2009
Cigarette smoke (CS)-induced lung inflammation involves the reduction of histone deacetylase 2 (HDAC2) abundance, which is associated with steroid resistance in patients with chronic obstructive pulmonary disease and in individuals with severe asthma who
Adenuga, David, Yao, Hongwei, Rahman, Irfan, Seagrave, JeanClare, March, Thomas H   +4 more
core   +1 more source

Acetate supplementation modulates brain histone acetylation and decreases interleukin-1β expression in a rat model of neuroinflammation

Journal of Neuroinflammation, 2012
Background Long-term acetate supplementation reduces neuroglial activation and cholinergic cell loss in a rat model of lipopolysaccharide-induced neuroinflammation.
Soliman Mahmoud L, Smith Mark D, Houdek Heidi M, Rosenberger Thad A   +3 more
doaj   +1 more source

Histone deacetylase 5 promotes the migration and invasion of hepatocellular carcinoma via increasing the transcription of hypoxia-inducible factor-1α under hypoxia condition

Tumor Biology, 2017
Hypoxia plays a critical role in the progression and metastasis of hepatocellular carcinoma by activating the key transcription factor, hypoxia-inducible factor-1.
Ming Ye, Zejun Fang, Hongqian Gu, Rui Song, Jiangwei Ye, Hongzhang Li, Zhiguang Wu, Shenghui Zhou, Peng Li, Xiang Cai, Xiaokun Ding, Songshan Yu   +11 more
doaj   +1 more source

Histone Deacetylases and Histone Deacetylase Inhibitors: Molecular Mechanisms of Action in Various Cancers

Advanced Biomedical Research, 2019
Epigenetic modifications such as histone modification play an important role in tumorigenesis. There are several evidence that histone deacetylases (HDACs) play a key role in cancer induction and progression by histone deacetylation.
Masumeh Sanaei, Fraidoon Kavoosi
doaj   +1 more source

Dissecting the roles of histone deacetylase 1 and 2 in the hematopoietic system [PDF]

, 2008
Reversible histone acetylation on lysine residues has been intensively studied as an epigenetic mark for gene activation in a variety of eukaryotes. Histone deacetylases (HDACs) act to repress gene expression by removing acetyl groups from histones and ...
Yamaguchi, Teppei
core   +1 more source

Comparative genomics of the class 4 histone deacetylase family indicates a complex evolutionary history

BMC Biology, 2006
Background Histone deacetylases are enzymes that modify core histones and play key roles in transcriptional regulation, chromatin assembly, DNA repair, and recombination in eukaryotes. Three types of related histone deacetylases (classes 1, 2, and 4) are
Vervoort Michel, Ledent Valérie
doaj   +1 more source