Results 11 to 20 of about 182,853 (310)

Inhibition of histone deacetylase as a treatment for cardiac hypertrophy [PDF]

, 2005
The present invention provides for methods of treating and preventing cardiac hypertrophy. Class II HDACs, which are known to participate in regulation of chromatin structure and gene expression, have been shown to have beneficial effects on cardiac ...
Bristow, Michael R., Long, Carlin, McKinsey, Timothy A., Olson, Eric N.   +3 more
core   +1 more source

Loss of deacetylation activity of Hdac6 affects emotional behavior in mice. [PDF]

PLoS ONE, 2012
Acetylation is mediated by acetyltransferases and deacetylases, and occurs not only on histones but also on diverse proteins. Although histone acetylation in chromatin structure and transcription has been well studied, the biological roles of non-histone
Masahide Fukada, Atsuko Hanai, Atsuo Nakayama, Takayoshi Suzuki, Naoki Miyata, Ramona M Rodriguiz, William C Wetsel, Tso-Pang Yao, Yoshiharu Kawaguchi   +8 more
doaj   +1 more source

Histone Deacetylases and Histone Deacetylase Inhibitors: Molecular Mechanisms of Action in Various Cancers

Advanced Biomedical Research, 2019
Epigenetic modifications such as histone modification play an important role in tumorigenesis. There are several evidence that histone deacetylases (HDACs) play a key role in cancer induction and progression by histone deacetylation.
Masumeh Sanaei, Fraidoon Kavoosi
doaj   +1 more source

Histone Deacetylase Inhibitors [PDF]

Journal of Thoracic Oncology, 2011
Histone modification and DNA methylation are critical events that determine gene expression. Histone deacetylases (HDAC) render several critical genes transcriptionally inactive by conferring a “hyperwound” configuration. HDAC inhibition leads to unwinding of the DNA and makes it available to the transcriptional machinery for expression of a number of ...
openaire   +2 more sources

Histone deacetylase 5 promotes the migration and invasion of hepatocellular carcinoma via increasing the transcription of hypoxia-inducible factor-1α under hypoxia condition

Tumor Biology, 2017
Hypoxia plays a critical role in the progression and metastasis of hepatocellular carcinoma by activating the key transcription factor, hypoxia-inducible factor-1.
Ming Ye, Zejun Fang, Hongqian Gu, Rui Song, Jiangwei Ye, Hongzhang Li, Zhiguang Wu, Shenghui Zhou, Peng Li, Xiang Cai, Xiaokun Ding, Songshan Yu   +11 more
doaj   +1 more source

Acetate supplementation modulates brain histone acetylation and decreases interleukin-1β expression in a rat model of neuroinflammation

Journal of Neuroinflammation, 2012
Background Long-term acetate supplementation reduces neuroglial activation and cholinergic cell loss in a rat model of lipopolysaccharide-induced neuroinflammation.
Soliman Mahmoud L, Smith Mark D, Houdek Heidi M, Rosenberger Thad A   +3 more
doaj   +1 more source

Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation [PDF]

, 2017
Current antiretroviral therapy (ART) for HIV/AIDS slows disease progression by reducing viral loads and increasing CD4 counts. Yet ART is not curative due to the persistence of CD4+ T-cell proviral reservoirs that chronically resupply active virus ...
Albert, Brice J, Barnes, Alexander B, Kyei, George B, Marshall, Garland R, Niu, Austin, Ramani, Rashmi, Ratner, Lee, Wender, Paul A, Williams, Robert M   +8 more
core   +2 more sources

Comparative genomics of the class 4 histone deacetylase family indicates a complex evolutionary history

BMC Biology, 2006
Background Histone deacetylases are enzymes that modify core histones and play key roles in transcriptional regulation, chromatin assembly, DNA repair, and recombination in eukaryotes. Three types of related histone deacetylases (classes 1, 2, and 4) are
Vervoort Michel, Ledent Valérie
doaj   +1 more source

Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors [PDF]

, 2010
Histone deacetylase inhibitors (HDI) dampen cellular innate immune response by decreasing interferon production and have been shown to increase the growth of vesicular stomatitis virus and HSV.
Atkins, H, Bell, JC, Breitbach, C, Cox, J, De Silva, N, Diallo, JS, Falls, T, Guimond, T, Huang, B, Kirn, D, Le Boeuf, F, MacTavish, H, McCart, AJ, Simmons, JG, Stanford, M, Thorne, S   +15 more
core   +1 more source

Histone Deacetylases in Stroke

Chinese Journal of Physiology, 2019
Stroke is the second leading cause of death and the leading cause of adult disability worldwide. Despite an impressive amount of neuroprotective agents that has been identified in experimental stroke, none of them proved efficient in clinical trials. There is a general consensus that an effective treatment requires the ability
Mei-Han Kao, Teng-Nan Lin
openaire   +3 more sources