Results 31 to 40 of about 237,704 (293)

Inhibition of Plk1 and Cyclin B1 expression results in panobinostat-induced G(2) delay and mitotic defects [PDF]

, 2013
Work by JP is funded by a Royal Society University Research Fellowship award. Experiments carried out by MBP were supported by the Department of Pathology, Albert Einstein College of Medicine / Montefiore Medical Center.The development of clinically ...
Parish, Joanna, Kawachi, Nicole, Loudig, Olivier, Feeney, Katherine, Antkowiak, Maciej, Prystowsky, Michael, Wasson, Christopher, Parish, Joanna; id_orcid, Willmott, Michelle, Montagna, Cristina   +9 more
core   +1 more source

Histone deacetylases and cancer [PDF]

Oncogene, 2007
Histone deacetylases (HDACs) regulate the expression and activity of numerous proteins involved in both cancer initiation and cancer progression. By removal of acetyl groups from histones, HDACs create a non-permissive chromatin conformation that prevents the transcription of genes that encode proteins involved in tumorigenesis. In addition to histones,
M A, Glozak, E, Seto
openaire   +2 more sources

HDAC3 (histone deacetylase 3) [PDF]

, 2008
Review on HDAC3 (histone deacetylase 3), with data on DNA, on the protein encoded, and where the gene is ...
Escaffit, F
core   +1 more source

HDAC3 blockade inhibits neuroinflammation and pyroptosis to prevent dopaminergic neuron death in Parkinson’s disease models

Neural Regeneration Research
Neuroinflammation, mediated by microglial cells, plays a crucial role in the progression of Parkinson’s disease. Although the importance of histone deacetylase 3 in neurodegenerative diseases is well recognized, its specific involvement in microglial ...
Wenwen Chen, Xinjue Wang, Yejing Zhang, Peili Sun, Yongcheng Jiang, Jianhong Shen, Tian Xu, Jiabing Shen, Kaifu Ke, Xiaosu Gu   +9 more
doaj   +1 more source

HDAC2 (histone deacetylase 2) [PDF]

, 2010
Review on HDAC2 (histone deacetylase 2), with data on DNA, on the protein encoded, and where the gene is ...
Esteller, M, M Esteller, Ropero, S, S Ropero   +3 more
core   +1 more source

EVALUATION OF HISTONE DEACETYLASE INHIBITOR EFFECTS ON THYROID CANCER [PDF]

, 2009
Histone deacetylases (HDACs) play a crucial role in the proper regulation of cellular functions through their connection with chromatin and transcriptional regulation.
Borbone, Eleonora
core   +1 more source

Histone Deacetylases and Their Isoform-Specific Inhibitors in Ischemic Stroke

Biomedicines, 2021
Cerebral ischemia is the second leading cause of death in the world and multimodal stroke therapy is needed. The ischemic stroke generally reduces the gene expression due to suppression of acetylation of histones H3 and H4.
Svetlana Demyanenko, Valentina Dzreyan, Svetlana Sharifulina   +2 more
doaj   +1 more source

The synergistic interaction between CD20 monoclonal antibodies and Histone Deacetylase inhibitors in B cell Non Hodgkin’s Lymphoma

, 2010
Recent improvements in molecular sub typing of Non Hodgkin’s lymphomashave resulted in targeted therapies becoming incorporated into treatmentparadigms.
Nolan, David Francis Luke
core   +2 more sources

Role of Histone Deacetylase 6 and Histone Deacetylase 6 Inhibition in Colorectal Cancer

Pharmaceutics, 2023
Histone deacetylase 6 (HDAC6), by deacetylation of multiple substrates and association with interacting proteins, regulates many physiological processes that are involved in cancer development and invasiveness such as cell proliferation, apoptosis ...
Ana Vuletić, Katarina Mirjačić Martinović, Jelena Spasić   +2 more
doaj   +1 more source

Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts

Haematologica, 2010
Background During the final stages of differentiation of mammalian erythroid cells, the chromatin is condensed and enucleated. We previously reported that Rac GTPases and their downstream target, mammalian homolog of Drosophila diaphanous 2 (mDia2), are ...
Peng Ji, Victor Yeh, Tzutzuy Ramirez, Maki Murata-Hori, Harvey F. Lodish   +4 more
doaj   +1 more source