Results 51 to 60 of about 228,208 (202)
Valproic acid decreases urothelial cancer cell proliferation and induces thrombospondin-1 expression
BMC Urology, 2012 Background Prevention of bladder cancer recurrence is a central challenge in the management of this highly prevalent disease. The histone deacetylase inhibitor valproic acid (sodium valproate) has anti-angiogenic properties and has been shown to decrease
Byler Timothy K +7 more
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Frontiers in Cell and Developmental Biology, 2020 Sorafenib resistance and tumor metastasis account for poor outcome of hepatocellular carcinoma (HCC). Histone deacetylase 11 (HDAC11) has been reported to exert oncogenic effects in several types of human cancer, but its specific functions and detailed ...
Wenlong Wang +3 more
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Two assembly modes for SIN3 histone deacetylase complexes
Cell Discovery, 2023 The switch-independent 3 (SIN3)/histone deacetylase (HDAC) complexes play essential roles in regulating chromatin accessibility and gene expression. There are two major types of SIN3/HDAC complexes (named SIN3L and SIN3S) targeting different chromatin ...
Chengcheng Wang +5 more
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Transcriptional gene silencing mutants in "Arabidopsis thaliana" and their impact on nuclear architecture and heterochromatin organization [PDF]
, 2004 The epigenetic regulation of gene expression is defined by covalent modifications of DNA and histone tails as well as by chromatin structure and nuclear architecture.
Valeska Probst, Aline
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Neural Regeneration ResearchRecent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-β in neurons, which is a key step in senile plaque formation.
Zhimin Long +7 more
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Frontiers in Molecular Neuroscience, 2017 The impairment of amyloid-β (Aβ) clearance in the brain plays a causative role in Alzheimer’s disease (AD). Polarity distribution of aquaporin-4 (AQP4) is important to remove Aβ from brain.
Jingzhu Zhang +8 more
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Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function [PDF]
, 2002 This work was supported by grants from the NIH (R01CA86072 to R.G.P. and R01CA72038-01 to S.A.W.F.) and The Susan Komen Breast Cancer Foundation (to R.G.P.). R.T.H. and E.J. were supported by the Medical Research Council. Y.-G.Y.
Wang, Jian +13 more
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Histone deacetylase inhibitors in treatment of cancer
, 2022 New studies have shown that histone deacetylase inhibitors can help as a novel antitumor drugs in cotherapy with conventional radiochemotherapy especially in CTCL. Several studies and clinical trials have used specific and non specific HDACi.
Metwaly, Laila Tarek Abbas
core
Acetylation site specificities of lysine deacetylase inhibitors in human cells [PDF]
, 2015 This work was supported by the Hallas Møller Investigator grant from the Novo Nordisk Foundation to C.C. S.A.W. and P.B. were supported by individual postdoctoral grants from the Danish Research Council (FSS: 10-085134, FSS: 12-12610). C.C.
Sebastian A Wagner +40 more
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Scientia Pharmaceutica, 2019 Histone deacetylase inhibitors with zinc binding groups often exhibit drawbacks like non-selectivity or toxic effects. Thus, there are continuous efforts to modify the currently available inhibitors or to discover new derivatives to overcome these ...
Duraid H. Al-Amily +1 more
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