Results 51 to 60 of about 123,729 (215)

HDAC4 Regulates Skeletal Muscle Regeneration via Soluble Factors

Frontiers in Physiology, 2018
Skeletal muscle possesses a high ability to regenerate after an insult or in pathological conditions, relying on satellite cells, the skeletal muscle stem cells.
Alessandra Renzini, Nicoletta Marroncelli, Chiara Noviello, Viviana Moresi, Viviana Moresi, Sergio Adamo   +5 more
doaj   +1 more source

Promoter Hypomethylation and miR-145-5p Downregulation- Mediated HDAC11 Overexpression Promotes Sorafenib Resistance and Metastasis of Hepatocellular Carcinoma Cells

Frontiers in Cell and Developmental Biology, 2020
Sorafenib resistance and tumor metastasis account for poor outcome of hepatocellular carcinoma (HCC). Histone deacetylase 11 (HDAC11) has been reported to exert oncogenic effects in several types of human cancer, but its specific functions and detailed ...
Wenlong Wang, Bisha Ding, Weiyang Lou, Shengyou Lin   +3 more
doaj   +1 more source

Two assembly modes for SIN3 histone deacetylase complexes

Cell Discovery, 2023
The switch-independent 3 (SIN3)/histone deacetylase (HDAC) complexes play essential roles in regulating chromatin accessibility and gene expression. There are two major types of SIN3/HDAC complexes (named SIN3L and SIN3S) targeting different chromatin ...
Chengcheng Wang, Zhouyan Guo, Chen Chu, Yichen Lu, Xiaofeng Zhang, Xiechao Zhan   +5 more
doaj   +1 more source

HDAC inhibitors: A novel approach to hyperglycaemia management and treatment

Health Sciences Review, 2023
The field of genomics plays a prominent role in treatment of numerous chronic diseases. Diabetes is a persistent metabolic disorder. Current studies and reports have emphasised the importance of several epigenetic markers in the therapy of type 2 ...
M. Suchitra, Kusuma Praveen Kumar, Manjunath.S. Katagi, Garla Venkateswarlu, P．Sree Mahalakshmi   +4 more
doaj   +1 more source

Resistance after chronic application of the HDAC-inhibitor valproic acid is associated with elevated Akt activation in renal cell carcinoma in vivo

, 2013
Targeted drugs have significantly improved the therapeutic options for advanced renal cell carcinoma (RCC). However, resistance often develops, negating the benefit of these agents.
Eva Juengel, Jasmina Makarević, Axel Haferkamp, Georg Bartsch, Roman A Blaheta, Jüngel, Eva, Nelson, Karen, Blaheta, Roman A., Igor Tsaur, Makarević, Jasmina, Karen Nelson, Tsaur, Igor, Haferkamp, Axel, Bartsch, Georg   +13 more
core   +1 more source

Valproic acid decreases urothelial cancer cell proliferation and induces thrombospondin-1 expression

BMC Urology, 2012
Background Prevention of bladder cancer recurrence is a central challenge in the management of this highly prevalent disease. The histone deacetylase inhibitor valproic acid (sodium valproate) has anti-angiogenic properties and has been shown to decrease
Byler Timothy K, Leocadio Dean, Shapiro Oleg, Bratslavsky Gennady, Stodgell Christopher J, Wood Ronald W, Messing Edward M, Reeder Jay E   +7 more
doaj   +1 more source

Enhanced autophagic clearance of amyloid-β via histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer’s disease in vitro and in vivo

Neural Regeneration Research
Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-β in neurons, which is a key step in senile plaque formation.
Zhimin Long, Chuanhua Ge, Yueyang Zhao, Yuanjie Liu, Qinghua Zeng, Qing Tang, Zhifang Dong, Guiqiong He   +7 more
doaj   +1 more source

Histone deacetylase inhibitors in treatment of cancer

, 2022
New studies have shown that histone deacetylase inhibitors can help as a novel antitumor drugs in cotherapy with conventional radiochemotherapy especially in CTCL. Several studies and clinical trials have used specific and non specific HDACi.
Metwaly, Laila Tarek Abbas
core  

Endocardial HDAC3 is required for myocardial trabeculation

Nature Communications
Failure of proper ventricular trabeculation is often associated with congenital heart disease. Support from endocardial cells, including the secretion of extracellular matrix and growth factors is critical for trabeculation.
Jihyun Jang, Mette Bentsen, Ye Jun Kim, Erick Kim, Vidu Garg, Chen-Leng Cai, Mario Looso, Deqiang Li   +7 more
doaj   +1 more source

Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness

Frontiers in Cell and Developmental Biology, 2020
Blindness arising from retinal or macular degeneration results in significant social, health and economic burden. While approved treatments exist for neovascular (‘wet’) age-related macular degeneration, new therapeutic targets/interventions are needed ...
Husvinee Sundaramurthi, Husvinee Sundaramurthi, Husvinee Sundaramurthi, Husvinee Sundaramurthi, Sarah L. Roche, Guinevere L. Grice, Ailis Moran, Ailis Moran, Eugene T. Dillion, Eugene T. Dillion, Giuseppe Campiani, James A. Nathan, Breandán N. Kennedy, Breandán N. Kennedy   +13 more
doaj   +1 more source