Results 41 to 50 of about 228,208 (202)

New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer

Journal of Hematology & Oncology, 2009
DNA methylation and histone acetylation are two well known epigenetic chromatin modifications. Epigenetic agents leading to DNA hypomethylation and histone hyperacetylation have been approved for treatment of hematological disorders.
Ma Yuehua, Cang Shundong, Liu Delong
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Histone acetylation modifiers in the pathogenesis of Alzheimer’s disease

Frontiers in Cellular Neuroscience, 2015
It is becoming more evident that histone acetylation, as one of the epigenetic modifications or markers, plays a key role in the etiology of Alzheimer’s disease (AD).
Xi eLu, Li eWang, Caijia eYu, Daohai eYu, Gang eYu   +4 more
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Exploring the role of histone deacetylase and histone deacetylase inhibitors in the context of multiple myeloma: mechanisms, therapeutic implications, and future perspectives

Experimental Hematology & Oncology
Histone deacetylase inhibitors (HDACis) are a significant category of pharmaceuticals that have developed in the past two decades to treat multiple myeloma. Four drugs in this category have received approval from the U.S.
Jingjing Pu, Ting Liu, Xuzhen Wang, Amit Sharma, Ingo G. H. Schmidt-Wolf, Liping Jiang, Jian Hou   +6 more
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Repressing iron overload ameliorates central post-stroke pain via the Hdac2-Kv1.2 axis in a rat model of hemorrhagic stroke

Neural Regeneration Research
Thalamic hemorrhage can lead to the development of central post-stroke pain. Changes in histone acetylation levels, which are regulated by histone deacetylases, affect the excitability of neurons surrounding the hemorrhagic area.
He Fang, Mengjie Li, Jingchen Yang, Shunping Ma, Li Zhang, Hongqi Yang, Qiongyan Tang, Jing Cao, Weimin Yang   +8 more
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Design, Synthesis and Cytotoxicity Study of Primary Amides as Histone Deacetylase Inhibitors

Iraqi Journal of Pharmaceutical Sciences, 2019
Primary amide derivatives as histone deacetylase inhibitors (HDACIs) are very rare. This paper describes the synthesis of primary amide derivatives (compounds 6 and 7) that have the requirements to be histone deacetylase inhibitors of the zinc-binding ...
Duraid Al-Amily, Mohammed H. Mohammed
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H3 Lysine 4 Is Acetylated at Active Gene Promoters and Is Regulated by H3 Lysine 4 Methylation [PDF]

, 2011
Methylation of histone H3 lysine 4 (H3K4me) is an evolutionarily conserved modification whose role in the regulation of gene expression has been extensively studied.
Richard J. Festenstein, Bonneil, Eric, Guillemette Benoit, Festenstein Richard J., Armstrong Harry, Festenstein, Richard J., Harry Armstrong, Imhof Axel, Armstrong, Harry, Richard J Festenstein, Drogaris, Paul, Axel Imhof, Verreault Alain, Kyoko Hiragami-Hamada, Drogaris Paul, Verreault, Alain, Benoit Guillemette, Thibault Pierre, Pierre Thibault, Lin Hsiu-Hsu Sophia, Hiragami-Hamada, Kyoko, Alain Verreault, Imhof, Axel, Paul Drogaris, Hsiu-Hsu Sophia Lin, Bonneil Éric, Eric Bonneil, Festenstein, Richard J, Hiragami-Hamada Kyoko, Guillemette, Benoit, Lin, Hsiu-Hsu Sophia, Thibault, Pierre   +31 more
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A review of the therapeutic potential of histone deacetylase inhibitors in rhabdomyosarcoma

Frontiers in Oncology, 2023
This review aims to summarize the putative role of histone deacetylases (HDACs) in rhabdomyosarcoma (RMS) and the effects of HDAC inhibitors (HDACi) on RMS by elucidating and highlighting known oncogenic pathways, mechanisms of resistance, and the ...
Omar Selim, Clara Song, Amy Kumar, Rebecca Phelan, Arun Singh, Noah Federman, Noah Federman, Noah Federman   +7 more
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HDAC inhibitors: A novel approach to hyperglycaemia management and treatment

Health Sciences Review, 2023
The field of genomics plays a prominent role in treatment of numerous chronic diseases. Diabetes is a persistent metabolic disorder. Current studies and reports have emphasised the importance of several epigenetic markers in the therapy of type 2 ...
M. Suchitra, Kusuma Praveen Kumar, Manjunath.S. Katagi, Garla Venkateswarlu, P．Sree Mahalakshmi   +4 more
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The synergistic interaction between CD20 monoclonal antibodies and Histone Deacetylase inhibitors in B cell Non Hodgkin’s Lymphoma

, 2010
Recent improvements in molecular sub typing of Non Hodgkin’s lymphomashave resulted in targeted therapies becoming incorporated into treatmentparadigms.
Nolan, David Francis Luke
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Inhibition of capsaicin and dihydrocapsaicin derivatives towards histone deacetylase and molecular docking studies [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2016
The natural products, capsaicin and dihydrocapsaicin, were modified at double-bond and phenolic moieties to provide twelve capsaicin and dihydrocapsaicin derivatives.
Pakit Kumboonma, Thanaset Senawong, Khatcharin Siriwong, Chavi Yenjai, Chanokbhorn Phaosiri   +4 more
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