Results 41 to 50 of about 123,729 (215)

Repressing iron overload ameliorates central post-stroke pain via the Hdac2-Kv1.2 axis in a rat model of hemorrhagic stroke

Neural Regeneration Research
Thalamic hemorrhage can lead to the development of central post-stroke pain. Changes in histone acetylation levels, which are regulated by histone deacetylases, affect the excitability of neurons surrounding the hemorrhagic area.
He Fang, Mengjie Li, Jingchen Yang, Shunping Ma, Li Zhang, Hongqi Yang, Qiongyan Tang, Jing Cao, Weimin Yang   +8 more
doaj   +1 more source

Design, Synthesis and Cytotoxicity Study of Primary Amides as Histone Deacetylase Inhibitors

Iraqi Journal of Pharmaceutical Sciences, 2019
Primary amide derivatives as histone deacetylase inhibitors (HDACIs) are very rare. This paper describes the synthesis of primary amide derivatives (compounds 6 and 7) that have the requirements to be histone deacetylase inhibitors of the zinc-binding ...
Duraid Al-Amily, Mohammed H. Mohammed
doaj   +1 more source

The histone deacetylase inhibitor valproic acid alters growth properties of renal cell carcinoma in vitro and in vivo

, 2008
Histone deacetylase (HDAC) inhibitors represent a promising class of antineoplastic agents which affect tumour growth, differentiation and invasion. The effects of the HDAC inhibitor valproic acid (VPA) were tested in vitro and in vivo on pre-clinical ...
Eva Juengel, Mickuckyte, Ausra, Hudak, Lukasz, Jones, Jon, Lukasz Hudak, Jüngel, Eva, Dietger Jonas, Blaheta, Roman A., Roman A. Blaheta, Wedel, Steffen Alexander, Ausra Mickuckyte, Jonas, Dietger, Jon Jones, Steffen Wedel   +13 more
core   +1 more source

Transcriptional gene silencing mutants in "Arabidopsis thaliana" and their impact on nuclear architecture and heterochromatin organization [PDF]

, 2004
The epigenetic regulation of gene expression is defined by covalent modifications of DNA and histone tails as well as by chromatin structure and nuclear architecture.
Valeska Probst, Aline
core   +1 more source

A review of the therapeutic potential of histone deacetylase inhibitors in rhabdomyosarcoma

Frontiers in Oncology, 2023
This review aims to summarize the putative role of histone deacetylases (HDACs) in rhabdomyosarcoma (RMS) and the effects of HDAC inhibitors (HDACi) on RMS by elucidating and highlighting known oncogenic pathways, mechanisms of resistance, and the ...
Omar Selim, Clara Song, Amy Kumar, Rebecca Phelan, Arun Singh, Noah Federman, Noah Federman, Noah Federman   +7 more
doaj   +1 more source

Inhibition of capsaicin and dihydrocapsaicin derivatives towards histone deacetylase and molecular docking studies [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2016
The natural products, capsaicin and dihydrocapsaicin, were modified at double-bond and phenolic moieties to provide twelve capsaicin and dihydrocapsaicin derivatives.
Pakit Kumboonma, Thanaset Senawong, Khatcharin Siriwong, Chavi Yenjai, Chanokbhorn Phaosiri   +4 more
doaj  

Intermittent Fasting Protects against Alzheimer’s Disease Possible through Restoring Aquaporin-4 Polarity

Frontiers in Molecular Neuroscience, 2017
The impairment of amyloid-β (Aβ) clearance in the brain plays a causative role in Alzheimer’s disease (AD). Polarity distribution of aquaporin-4 (AQP4) is important to remove Aβ from brain.
Jingzhu Zhang, Zhipeng Zhan, Zhipeng Zhan, Xinhui Li, Aiping Xing, Congmin Jiang, Yanqiu Chen, Wanying Shi, Li An   +8 more
doaj   +1 more source

Histone Deacetylases in Retinoblastoma

International Journal of Molecular Sciences
Retinoblastoma, a pediatric ocular malignancy, presents significant challenges in comprehending its molecular underpinnings and targeted therapeutic approaches. The dysregulated activity of histone deacetylases (HDACs) has been associated with retinoblastoma pathogenesis, influencing critical cellular processes like cell cycle regulation or retinal ...
Malwina Lisek, Julia Tomczak, Julia Swiatek, Aleksandra Kaluza, Tomasz Boczek   +4 more
openaire   +2 more sources

Beyond Histone and Deacetylase: An Overview of Cytoplasmic Histone Deacetylases and Their Nonhistone Substrates [PDF]

BioMed Research International, 2010
Acetylation of lysines is a prominent form of modification in mammalian proteins. Deacetylation of proteins is catalyzed by histone deacetylases, traditionally named after their role in histone deacetylation, transcriptional modulation, and epigenetic regulation. Despite the link between histone deacetylases and chromatin structure, some of the histone
Yao, Ya-Li, Yang, Wen-Ming
openaire   +2 more sources

Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model

, 2011
NOTICE: this is the author’s version of a work that was accepted for publication in Neurobiology of Disease. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control ...
Ezzatizadeh, V, Rusche, James R., Steve Jones, James R. Rusche, Gottesfeld, Joel M., Jones, S, Sandi, C, Barnes, Glenn, Joel M. Gottesfeld, Pook, MA, Pinto, RM, Al-Mahdawi, Sahar, Chiranjeevi Sandi, Sandi, Chiranjeevi, Barnes, G, Mark A. Pook, Pinto, Ricardo Mouro, Al-Mahdawi, S, Jones, Steve, Pook, Mark A., Vahid Ezzatizadeh, Ezzatizadeh, Vahid, Sahar Al-Mahdawi, Rusche, JR, Ricardo Mouro Pinto, Gottesfeld, JM, Glenn Barnes   +26 more
core   +1 more source