Results 61 to 70 of about 123,729 (215)

Design, Synthesis, and Docking Study of Acyl Thiourea Derivatives as Possible Histone Deacetylase Inhibitors with a Novel Zinc Binding Group

Scientia Pharmaceutica, 2019
Histone deacetylase inhibitors with zinc binding groups often exhibit drawbacks like non-selectivity or toxic effects. Thus, there are continuous efforts to modify the currently available inhibitors or to discover new derivatives to overcome these ...
Duraid H. Al-Amily, Mohammed Hassan Mohammed   +1 more
doaj   +1 more source

Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer

, 2008
Background Enhanced activity of histone deacetylases (HDAC) is associated with more aggressive tumour behaviour and tumour progression in various solid tumours.
Dietel Manfred, Fritzsche, Florian R., Weichert Wilko, Gekeler Volker, Dietel, Manfred, Fritzsche Florian R, Beckers Thomas, Kristiansen Glen, Jung, Klaus, Kristiansen, Glen, Weichert, Wilko, Jung Klaus, Scholman Katharina, Gekeler, Volker, Denkert Carsten, Röske, Annika, Röske Annika, Beckers, Thomas, Stephan, Carsten, Stephan Carsten, Scholman, Katharina, Denkert, Carsten Michael   +21 more
core   +1 more source

The histone H3 lysine 36 methyltransferase HypB facilitates embryonic stem cell differentiation [PDF]

, 2007
Histone H3 lysine 36 (H3K36) methylation was identified as a conserved modification from yeast to human. In yeast, biochemical characterization of the SET2 protein and genome wide mapping of H3K36me2 and K36me3 indicate that H3K36 methylation functions ...
Wang, Tianke
core   +1 more source

SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease [PDF]

, 2008
RATIONALE:Abnormal inflammation and accelerated decline in lung function occur in patients with chronic obstructive pulmonary disease (COPD). Human sirtuin (SIRT1), an antiaging and antiinflammatory protein, is a metabolic NAD(+)-dependent protein ...
Rajendrasozhan, Saravanan, Kinnula, Vuokko L, Rahman, Irfan, Yang, Se-Ran   +3 more
core   +1 more source

Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression [PDF]

, 2012
Chemical inhibitors of histone deacetylase (HDAC) activity are used as experimental tools to induce histone hyperacetylation and deregulate gene transcription, but it is not known whether the inhibition of HDACs plays any part in the normal physiological
Sproul, Duncan, Mackay, Logan, Culley, Jayne, Ramsahoye, Bernard H, Langridge-Smith, Pat, Gilbert, Nick, Harrison, David J, Latham, Tom, Hayward, Larry, Ramsahoye, Bernard H., Karim, Muhammed, Harrison, David J.   +11 more
core   +1 more source

HISTONE DEACETYLASE INHIBITORS FOR CANCER TREATMENT DRUG DEVELOPMENT IN CONTEMPORARY ONCOLOGY

, 2014
inhibitors as novel anticancer therapeutics D.R. Walkinshaw MSc * and X.J. Yang PhD* Histone deacetylase inhibitors represent a promising new class of compounds for the treatment of cancer.
Key Words, Histone Deacetylase
core  

The role of HDAC2 in chromatin remodelling and response to chemotherapy in ovarian cancer [PDF]

, 2015
This study was supported by financial support from the University of Edinburgh/China Scholarship Council joint Scholarship Scheme. We are also grateful to support from the Scottish Funding Council.Chromatin undergoes structural changes in response to ...
Mullen, Peter, Um, In Hwa, Huang, Rui, Langdon, Simon, Tse, Matthew, Harrison, David, Harrison, David James, Langdon, Simon P., Faratian, Dana   +8 more
core   +1 more source

Droxinostat, a Histone Deacetylase Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cell Lines via Activation of the Mitochondrial Pathway and Downregulation of FLIP

Translational Oncology, 2016
Background: The current chemotherapeutic outcomes for hepatocellular carcinoma (HCC) are not encouraging, and long-term survival of this patient group remains poor.
Jing Liu, Guangming Li, Xiang Wang, Liang Wang, Rui Zhao, Juanxia Wang, Yin Kong, Jie Ding, Juan Li, Lingyi Zhang   +9 more
doaj   +1 more source

Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents

, 2013
Katherine Ververis,1 Alison Hiong,1 Tom C Karagiannis,1,* Paul V Licciardi2,*1Epigenomic Medicine, Alfred Medical Research and Education Precinct, 2Allergy and Immune Disorders, Murdoch Childrens Research Institute, Melbourne, VIC, Australia*These ...
Ververis, K, Hiong A, Ververis K, Karagiannis, TC, Licciardi, PV, Karagiannis TC, Hiong, A, Licciardi PV   +7 more
core   +1 more source

Mbd2 contributes to DNA methylation-directed repression of the Xist gene [PDF]

, 2007
Transcription of the Xist gene triggers X chromosome inactivation in cis and is therefore silenced on the X chromosome that remains active. DNA methylation contributes to this silencing, but the mechanism is unknown.
Hermann, Andrea, Prokhortchouk, Anna, Adie, Karen, Hendrich, Brian, Barr, Helen, Tsai, Hsin-Hao, Berger, Jennifer, Bird, Adrian; id_orcid   +7 more
core   +1 more source